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Pathogenic microorganism infection diagnosis type cell chip and method for preparing the same

A pathogenic microorganism and cell chip technology, which is applied in the field of pathogenic microorganism infection diagnostic cell chip and its preparation, can solve the problems of slow detection speed, poor accuracy, high cost, etc., and achieve the effect of easy mastery, low cost and low cost

Inactive Publication Date: 2004-08-18
SHANXI LIFEGEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The invention solves the technical problems of low throughput, high cost, slow detection speed and poor accuracy in the background technology

Method used

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  • Pathogenic microorganism infection diagnosis type cell chip and method for preparing the same
  • Pathogenic microorganism infection diagnosis type cell chip and method for preparing the same
  • Pathogenic microorganism infection diagnosis type cell chip and method for preparing the same

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Embodiment Construction

[0043] see figure 1 , 2 , 3. The pathogenic microorganism infection diagnostic cell chip of the present invention is mainly composed of a substrate 1 , a reaction tank 2 , and a cell sheet 3 . The substrate 1 can be made of organic polymer material, metal or silicon, etc., and the reaction tank 2 for placing the cell sheet 3 is processed on it, and the reaction tank 2 can be one, two or more according to the detection requirements, so as to be arranged as an array. More than one cloth is better. The cell sheet 3 is a cell sheet 3 corresponding to the shape of the reaction tank 2 cut from a bacterial smear of pathogenic microorganisms such as bacteria, fungi, and spirochetes or a cell sheet coated with virus-infected eukaryotic cells, the material of the cell sheet It can be glass, plastic or nitrocellulose film, etc. The cell sheet 3 is embedded in the reaction tank 2 . The cell sheet is coated with a specific antigen for a certain pathogenic microorganism, so it can be di...

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Abstract

The present invention is cell chip for diagnosis of pathogenic microbe infection and its preparation process. The chip has reaction slots set on the substrate and cell sheet inside the reaction slots. Viral infection cell sheet is prepared through the steps of: preparing substrate with organic polymer, metal or silicon and making reaction slots on the substrate surface via micromachining; preparing cell sheet, viral infection cell sheet or pathogenic microbe cell sheet according to pathogenic microbe to be detected; and preparing cell chip via adhering the cell sheet into the reaction slots. The cell chip for diagnosis of pathogenic microbe infection of the present invention has high flux and low cost and is fast and accurate.

Description

technical field [0001] The invention relates to a pathogenic microorganism infection diagnosis type cell chip and a preparation method thereof. Background technique [0002] Infectious diseases are common and frequently-occurring diseases that endanger people's health and life. The prevalence of infection and the complexity of pathogenicity make the clinical diagnosis and treatment of this kind of disease very difficult, and an effective and rapid diagnostic technique is urgently needed. [0003] For the detection of viral disease pathogens, due to the difficulty in culturing the virus, the time is long, the positive rate is low, and it is not easy to operate, so the clinical diagnosis of virus infection mainly relies on serological methods and molecular biological methods. However, the above two types of methods have shortcomings or deficiencies to varying degrees. For example: neutralization test, complement fixation test, and hemagglutination inhibition test have limita...

Claims

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Application Information

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IPC IPC(8): C12Q1/04
Inventor 陈超陆学东高婧孟涛王琼李莉杨来智罗超贺丽丽张敏睿
Owner SHANXI LIFEGEN