Quickly disintegrated fenofibrate oral prepn

An oral preparation, fenofibrate technology, which is applied in the field of synthetic drug oral preparations, can solve the problem of not seeing the patent reports of fenofibrate fast disintegrating oral preparation dispersible tablets and granules, etc.

Inactive Publication Date: 2004-09-08
ANHUI NEW STAR PHARMA DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no patent reports on fenofibrate rapidly disintegrating oral preparations, dispersible tablets and granules

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0013] Through the following non-limiting examples, the technical solution of the present application is described as follows.

[0014] (1) Preparation of dispersible tablets

[0015] The specifications include fenofibrate: 25, 50, 100, 200, 400 mg / tablet. The following is an example of the specification of 100 mg / tablet to illustrate the preparation process of fenofibrate dispersible tablets.

[0016] 1. The ratio of raw and auxiliary materials:

[0017] Fenofibrate 100g

[0018] Microcrystalline cellulose 120g

[0019] Low-substituted cellulose 30g

[0020] Compressible starch 15g

[0021] Sodium Carboxymethyl Starch 308

[0022] Sodium lauryl sulfate 5g

[0023] Magnesium stearate 5g

[0024] 3% PVP appropriate amount

[0025] 1000 pieces

[0026] Weigh the raw and auxiliary materials according to the prescription, take the prescription amount of sodium lauryl sulfate, pu...

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PUM

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Abstract

The quickly disintegrated Fenofibrate oral preparation is dispersed tablet or granule prepared through mixing Fenofibrate and pharmaceutically acceptable supplementary material and contains Fenofibrate in 5-90 %. In case of existing water, the quickly disintegrated Fenofibrate oral preparation may be disintegrated within 5 min for human body to absorb to produce treating effect. It has relatively lower dosage and thus less toxic side effect.

Description

1. Technical Field [0001] The invention relates to a synthetic drug oral preparation, in particular to an oral preparation of fenofibrate that disintegrates rapidly. 2. Background technology [0002] Fenofibrated (Fenofibrated), molecular formula C 20 H 21 ClO 4 , With a molecular weight of 360.84, it is a phenoxyacetic acid type of blood lipid lowering drug, its lipid-lowering effect is accurate, and it is the first choice for lowering triglyceride drugs. Fenofibrate can effectively inhibit HMGCoA reductase and reduce intracellular cholesterol synthesis; increase the number of low-density lipoprotein (LDL) receptors on the liver cell membrane, accelerate the transfer of LDL from the blood to the liver cell, thereby promoting the blood Clear cholesterol and improve glucose tolerance; increase lipoproteinase activity, promote the decomposition of very low density lipoprotein (VLDL), and reduce the concentration of triglycerides in the blood. In addition, by inhibiting the esterifi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K9/20A61K31/216A61P3/06
Inventor 李晓祥李德刚
Owner ANHUI NEW STAR PHARMA DEV
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