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Chinese traditional medicine preparation Qimaishen for treating viral myocarditis and its manufacturing method

A technology of viral myocarditis and traditional Chinese medicine preparations, which is applied to antiviral agents, medical formulas, medical preparations containing active ingredients, etc., to achieve the effects of definite curative effect, convenient use, and fast efficacy

Inactive Publication Date: 2004-11-03
徐东铭
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Ginseng, Radix Astragali, and Ophiopogon japonicus are widely used as medicines for treating cardiovascular and other diseases, but there is no effective preparation for treating viral myocarditis in clinical practice.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] a. Prepare each extract of Radix Astragali, Ophiopogon japonicus and American ginseng

[0047] (1). Take 13kg of Astragalus membranaceus, 10kg of Ophiopogon japonicus, and 4kg of American ginseng and grind them into coarse powder respectively, add 20 times of water respectively, heat and boil three times, 1 hour each time;

[0048] (2) Astragalus, Ophiopogon japonicus and American ginseng were combined for three times, ethanol was recovered, concentrated, the concentrated solution was diluted, and filtered: respectively collected and combined the water extracts of Astragalus, Ophiopogon japonicus and American ginseng, and concentrated to 50°C The relative density is 1.10;

[0049] (3) Add ethanol to the concentrates of Radix Astragali, Ophiopogon japonicus and American ginseng respectively until the alcohol concentration reaches 40%, leave them for 24 hours respectively, filter, recover the ethanol from the filtrate until there is no alcohol smell, dilute and filter;

...

Embodiment 2

[0055] a. Preparation of total extracts of Radix Astragali, Ophiopogon japonicus and American ginseng

[0056] (1). Take 13kg of Astragalus membranaceus, 10kg of Ophiopogon japonicus, and 4kg of American ginseng, mix and grind them into a coarse powder, add 5 times the amount of water, heat and boil three times, 1 hour each time.

[0057] (2) Collecting and merging the obtained water extracts, concentrating to a relative density of 1.10 at 80°C;

[0058] (3) Add ethanol to the concentrated solution until the alcohol concentration reaches 90%, let it stand for 24 hours, filter, recover the ethanol from the filtrate until there is no alcohol smell, dilute and filter.

[0059] (4) Adsorb the filtrate through a macroporous adsorption resin column (D21 type), elute the resin column with 20% ethanol until the eluate is colorless, discard the eluate, and then elute with 50% ethanol Resin column, collect eluent;

[0060] (5) 50% ethanol eluent passes through cationic resin column an...

Embodiment 3

[0064] a. Prepare the total extracts of Astragalus, Radix Ophiopogon japonicus and American ginseng leaves

[0065] (1). Take 13kg of Astragalus membranaceus, 10kg of Ophiopogon japonicus, and 4kg of American ginseng, mix and grind them into a coarse powder, add 30 times of water, heat and boil 5 times, 0.5 hours each time.

[0066] (2) Collect and combine the obtained water extracts, and concentrate to a relative density of 1.10 at 50°C;

[0067] (3) Add ethanol to the concentrated solution until the alcohol concentration reaches 60%, leave it for 24 hours, filter, recover ethanol from the filtrate until there is no alcohol smell, dilute and filter.

[0068] (4) Adsorb the filtrate through a macroporous adsorption resin column, elute the resin column with 20% ethanol, and discard the eluent until the eluate is colorless, then elute the resin column with 60% concentration ethanol, collect eluent;

[0069] (5) 60% ethanol eluent passes through cationic resin column and anion ...

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PUM

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Abstract

The Chinese medicine preparation for treating viral myocarditis is prepared with astragalus root, ophiopogon root and American ginseng root or leaf in certain proportion, and through decoction, ethanol precipitation to eliminate impurity, refining with macroporous resin, elution with ethanol to obtain eluted liquid, filtering and other steps. It is prepared into injection for intravenous injection or intramuscular injection to result in obvious curative effect, and may be also prepared into other preparation forms, including freeze dried powder for injection, tablet, granule, dripping pill, bolus, etc. With the functions of benefiting vital energy, nourishing Yin, strengthening body's resistance, eliminating evil and stopping pulsation, the Chinese medicine preparation is used in treating viral myocarditis, coronary heart disease, angina pectoris and other cardiac vascular diseases.

Description

Technical field: [0001] The invention relates to a qimaishen traditional Chinese medicine preparation for treating viral myocarditis and a preparation method thereof, and provides a qimaishen injection, which belongs to the technical field of traditional Chinese medicine preparations. Background technique: [0002] At present, viral myocarditis has become a common disease in the field of medical internal medicine, which is extremely harmful, but so far there is no safe and effective traditional Chinese medicine preparation for injection administration; clinically effective empirical prescriptions have more medicinal flavors, and they are all taken orally in decoction , there is no injection form of traditional Chinese medicine, and there are more oral dosage forms. Not only the body absorbs the medicine slowly, but also it is inconvenient to use. Directly affect the therapeutic effect and scope of use of this type of medicine. [0003] Ginseng, Radix Astragali, and Ophiopog...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61P9/00A61P31/12
Inventor 徐东铭徐暾海刘平徐雅娟
Owner 徐东铭
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