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Method and apparatus for measuring biological tissue multi-frequency impedance

A technology of impedance measurement and biological tissue, applied in diagnostic recording/measurement, medical science, diagnosis, etc., can solve the problems of no practical instrument, complicated instrument design scheme, and lack of impedance model parameter extraction and analysis functions

Inactive Publication Date: 2004-11-10
HUAZHONG UNIV OF SCI & TECH
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Problems solved by technology

Biological tissue multi-frequency impedance measurement instrument is not yet practical
In addition, the existing instruments in the development and experiment stage are relatively complex in design, simple in performance, very simple in algorithm and realized in function, and high in cost.
And it does not have the function of impedance model parameter extraction and analysis
It is impossible to monitor the parameters of the biological impedance model in the body for a long time (refer to the invention patent CN1312052A, a biological impedance measuring device composed of a single-chip integrated circuit, the disclosure date was September 12, 2001)

Method used

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  • Method and apparatus for measuring biological tissue multi-frequency impedance
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  • Method and apparatus for measuring biological tissue multi-frequency impedance

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Embodiment Construction

[0055] 1. The principle and calculation formula of the linear transformation iterative least squares fitting method:

[0056] The linear transformation iterative least squares fitting method is a method that combines the linear transformation of the fitted circle coordinates with iterative fitting. The principle is that the roundness error reflects the radial deviation between the actual circle and the ideal circle. The classic roundness error The evaluation calculation method is the least squares fitting method, and its mathematical model expresses the coordinates of the center of the circle in the determination of the least squares (x 0 ,y 0 ), the basic idea is to minimize the sum of squared radius errors. i.e. model 1

[0057] F ( x 0 , y 0 , r ) = Σ i ...

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Abstract

The invention discloses biological tissue multiple frequency impedance measuring method and measuring apparatus thereof, wherein the linear transformation iterate method of curve fitting is first applied to the extraction of biological tissue impedance model parameter, which can realize accurate matching only through limited frequencies. The measuring apparatus includes a single chip machine for data acquisition, a direct digital frequency synthesizer, a voltage control constant-current source, a current electrode, a voltage measurement and reference signal magnification and filtering circuit, an amplitude discrimination device, a shaping and phase detector, a PC and an isolated serial line interface.

Description

technical field [0001] The invention belongs to the technical field of biological detection, and in particular relates to a biological tissue multi-frequency impedance measurement method and a device thereof. Background technique [0002] Extracting tissue impedance model parameters by measuring bio-impedance spectrum can realize continuous real-time monitoring of human physiological function status and detection of pathological events, which will have a very broad application prospect for medical clinical diagnosis. For example, in the state of sitting for a long time, the lower limbs are bent and immobile, which will lead to poor blood flow in the lower limbs, insufficient blood supply to the legs, and the decrease of low-resistivity cells in the measured part. Re has little influence. The model parameters provide quantitative data, and the model parameters of electrical impedance are an important index to quantitatively distinguish tissues in different physiological stat...

Claims

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Application Information

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IPC IPC(8): A61B5/053G06F17/00
Inventor 杨玉星袁世英周黎明
Owner HUAZHONG UNIV OF SCI & TECH
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