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Method for making biologic composite materials of nanometer hydroxyapatite/polyamide series for medical use

A technology of nano-hydroxyapatite and composite materials, which is applied in medical science and prostheses, and can solve problems such as low output, expensive solvents, and difficult process control

Inactive Publication Date: 2004-11-10
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Due to the high reaction temperature of this preparation method, the polyamide will be oxidized and discolored when the temperature is too high during the dissolution process, the process control is difficult, and the solvent is expensive, and the entire composite process takes a long time (about 9 hours for the composite process). In "Reno, Nevada, USA" April 30~May 3, 2003: 596, the in-situ co-precipitation method was introduced to prepare composite materials. First, Ca(NO 3 ) 2 Dissolve in acetamide solution, and then dissolve polyamide 66 in it under the condition of heating at 140°C, and finally add Na 3 PO 4 , in situ generation of homogeneously dispersed needle-like nano-hydroxyapatite crystals in polyamide 66 in acetamide solution, but in low yield

Method used

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  • Method for making biologic composite materials of nanometer hydroxyapatite/polyamide series for medical use
  • Method for making biologic composite materials of nanometer hydroxyapatite/polyamide series for medical use
  • Method for making biologic composite materials of nanometer hydroxyapatite/polyamide series for medical use

Examples

Experimental program
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Embodiment 1

[0022]Dissolve 15 g of calcium chloride in 150 ml of methanol solvent, add 15 g of polyamide 66, and dissolve at 55°C under stirring. The nano-hydroxyapatite slurry is prepared by the wet synthesis and hydrothermal treatment method reported in the above-mentioned "J. Mater. Sci.: Mater. in Med." 5 (1994): 252-255 (water content 66%), Weigh 29.4 grams of the slurry, mix 1.5 grams of polyethylene glycol 6000 and 50 ml of methanol into the slurry and stir well. The aqueous methanol slurry of nano-hydroxyapatite was slowly added to the calcium chloride / methanol solution of polyamide 66, and the mixture was kept fully stirred at 55°C for 2 hours to prepare nano-hydroxyapatite / polyamide 66 (weight The ratio is 4 / 6) composite materials. All reagents used are analytical grade (AR). The product mixture after the reaction is precipitated in deionized water, and then washed with hot deionized water for 6 times, anhydrous ethanol for 2 times, dried at 100° C., and ground for use.

Embodiment 2

[0024] The polyamide material was changed to polyamide 6, and the nano-hydroxyapatite slurry and other operating methods and conditions were the same as in Example 1, to prepare a nano-hydroxyapatite / polyamide 6 (weight ratio of 4 / 6) composite material.

Embodiment 3

[0026] Dissolve 25 g of calcium chloride in 150 ml of methanol solvent, add 30 g of polyamide 66, and dissolve at 50°C under stirring. The preparation method of the nano-hydroxyapatite slurry is the same as in Example 1. Weigh 22.05 grams of the slurry (with a water content of 66%), mix 1.2 grams of polyethylene glycol 6000 and 40 ml of methanol into the slurry and stir evenly. The calcium chloride / methanol solution of polyamide 66 was slowly added to the aqueous methanol slurry of nano-hydroxyapatite, and the temperature was maintained at 60 ℃ and fully stirred for 1 hour to prepare nano-hydroxyapatite / polyamide 66 ( 20 / 80) Composite materials. All reagents used are analytical grade (AR).

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Abstract

The invention relates to a process for preparing nano hydroxyapatite / polyamide series biological medical composite material by using polyamides component and nano hydroxyapatite as raw material, wherein the weight ration of polyamides / nano hydroxyapatite is 8 / 2-2 / 8, through the steps of, dissolving polyamides into methanol solution, mixing nano hydroxyapatite into nano hydroxyapatite slurry consisting polyethylene glycol and water or methanol solution containing water, mixing the two for recombination while stirring, water sedimentation of the obtained product, washing with hot-water and anhydrous alcohol respectively.

Description

Technical field [0001] The invention relates to a method for preparing nano-level apatite / polyamide series biomedical composite materials under normal pressure and mild conditions. Background technique [0002] For biomedical composite materials used for bone replacement, in order to increase the content of hydroxyapatite in the composite material and ensure that the composite material has better biological activity, nano-hydroxyapatite and polymer composites can be used. In "Biomaterials" 2001, 22(13): 1705-1711, Kikuchi M once reported that Ca(OH) 2 And H 3 PO 4 Self-assembled on porcine collagen to generate nano-hydroxyapatite crystals, and then the composite material was cold isostatically pressed under a pressure of 200 MPa to prepare biomimetic bone. In "Journal of Sol-Gel Science and Technology" 2001, 21(1): 7-12, Nemoto R reported the preparation of a low-viscosity sol in which nano-hydroxyapatite and silk protein were directly compounded by ball milling. Li Yubao’s resea...

Claims

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Application Information

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IPC IPC(8): A61L27/44
Inventor 李玉宝左奕魏杰
Owner SICHUAN UNIV
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