Technological method of catalytic synthesizing medical biodegradable material with biomass organic guanidine compound

A technology of biodegradable materials and process methods, applied in the fields of medical biodegradable materials, ring-opening polymerization of cyclic ester monomers, and synthesis of polyester polymers, can solve hidden dangers of safety, cytotoxicity, and removal of tin-containing catalysts And other issues

Inactive Publication Date: 2004-12-22
NANKAI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is a relatively serious problem in the biodegradation synthesis of polyester materials at home and abroad: divalent tin compounds, which are used for polymerization reactions and are recognized as the best commercial catalysts for catalytic efficiency (such as: polylactic acid synthesized by melting polycondensation method) , the commercial catalyst stannous chloride of polyglycolic acid and tin protochloride-p-toluenesulfonic acid, the commerc

Method used

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  • Technological method of catalytic synthesizing medical biodegradable material with biomass organic guanidine compound
  • Technological method of catalytic synthesizing medical biodegradable material with biomass organic guanidine compound
  • Technological method of catalytic synthesizing medical biodegradable material with biomass organic guanidine compound

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Experimental program
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Effect test

Embodiment 1

[0018] In the reaction kettle, 144 grams of lactide were charged, and 119 mg of creatine was added according to monomer: catalyst=1000: 1 (molar ratio). Vacuumize the reactor, then replace it with nitrogen and repeat the operation three times, close the reactor under vacuum, heat the reactor slowly, and react at a constant temperature (150° C.) for a certain period of time for 72 hours. After stopping the reaction, the reactor was cooled to room temperature, and then acetone was added to dissolve the polymer in the reactor. Deionized water was then added to precipitate the polymer. The water phase was filtered off, and finally the precipitate was placed in a vacuum drying oven and dried under vacuum at 50° C. for 24 hours to obtain a white powdery solid with a yield of 97%. The polymer molecular weight is 1.0~2.0×10 4 , PDI≤1.40.

Embodiment 2

[0020] 144 grams of lactide were charged into the reactor, and 113 milligrams of creatinine was added according to monomer:catalyst=1000:1 (molar ratio). Vacuumize the reactor, then replace it with nitrogen and repeat the operation three times, close the reactor under vacuum, heat the reactor slowly, and react at a constant temperature (130° C.) for a certain period of time for 72 hours. After stopping the reaction, the reactor was cooled to room temperature, and then acetone was added to dissolve the polymer in the reactor. Deionized water was then added to precipitate the polymer. The water phase was filtered off, and finally the precipitate was placed in a vacuum drying oven and dried in vacuum at 50° C. for 24 hours to obtain a white powdery solid with a yield of 98.5%. The polymer molecular weight is 1.0~2.0×10 4 , PDI≤1.30.

Embodiment 3

[0022] In the reactor, 144 grams of lactide were charged, and 105 mg of guanidinoacetic acid was added according to monomer: catalyst=1000: 1 (molar ratio). Vacuumize the reactor, then replace it with nitrogen and repeat the operation three times, close the reactor under vacuum, heat the reactor slowly, and react at a constant temperature (150° C.) for a certain period of time for 72 hours. After stopping the reaction, the reactor was cooled to room temperature, and then acetone was added to dissolve the polymer in the reactor. Deionized water was then added to precipitate the polymer. The aqueous phase was filtered off, and finally the precipitate was placed in a vacuum drying oven and dried in vacuum at 50° C. for 24 hours to obtain a white powdery solid with a yield of 96.5%. The polymer molecular weight is 1.0~2.0×10 4 , PDI≤1.40.

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Abstract

A process for catalytically synthesizing the medical biodegradable material features that the non-toxic non-metal biologic organic guanidine compound (bio-GD), such as creatine, creatinine, and guanidinoacetic acid, is used as catalyst for the open-loop polymerizing reaction of cycloester monomers (L-lactide, glycolide, etc). Its advantage is no environmental pollution.

Description

technical field [0001] The invention relates to a medical biodegradable material, in particular to a new process for synthesizing polyester polymers, using biomass organic guanidine compound bio-GD (creatine, creatinine, guanidinoacetic acid) as a catalyst for cyclic esterification The invention relates to ring-opening polymerization of (lactide, lactone) monomers, belonging to the technical field of polymer chemistry. Background technique [0002] In recent years, with the rapid development of medicine and biological tissue engineering science in the world, the demand for medical biodegradable materials has grown rapidly at home and abroad. In artificially synthesized medical biodegradable materials, aliphatic polyester [such as: poly L-lactic acid P (L-LA), poly D, L-lactic acid P (D, L-LA), polyglycolic acid PGA, polyhexamethylene Lactone PCL and its copolymers, etc.] are the most valued. Due to the excellent biocompatibility and biosafety of this kind of material, it h...

Claims

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Application Information

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IPC IPC(8): C08G63/08C08G63/82
Inventor 李弘王晨宏赵晓娜
Owner NANKAI UNIV
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