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Process for producing polyvinyl alcohol particle embolism agent

A technology of polyvinyl alcohol and production process, which is applied in the direction of suppository delivery, medical preparations of non-active ingredients, pharmaceutical formulas, etc., and can solve problems such as relatively expensive prices and high particle size requirements

Inactive Publication Date: 2005-01-12
郑隆泗
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The key technology of interventional therapy is the particle embolism used to block the blood supply of tumor tissue, which has a high requirement on the size of the particle, and now the foam particles imported from abroad are more expensive; how to prepare a cheap and good particle embolism The manufacturing process is the problem to be solved in the present invention

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Embodiment 1: the manufacturing process of this polyvinyl alcohol particle embolic agent is mainly realized by the following steps, 1), polyvinyl alcohol is prepared into polyvinyl formal by condensation reaction according to a conventional process; the conventional process is specifically: 75 grams of polyvinyl alcohol raw materials are soaked in 800 grams of ethanol solution for at least half an hour and stirred, heated to about 90°C, kept warm until dissolved, and filtered to form a polyvinyl alcohol solution; cooled to 80°C-85°C, in Add 16 grams of sulfuric acid to the polyvinyl alcohol solution and form a mixed solution after stirring; add 16 grams of 37% formaldehyde to the mixed solution and keep it at 78°C-80°C. After stirring, it will become a white viscous liquid. The reaction is terminated; 5.5 grams of sodium hydroxide is added for neutralization, and the mixture is stirred to below 40°C to obtain the finished product. 2) After the process of washing and rem...

Embodiment 2

[0008] Embodiment 2: the manufacturing process of this polyvinyl alcohol particle embolic agent is mainly realized by the following steps, 1), polyvinyl alcohol is prepared into polyvinyl formal by condensation reaction according to a conventional process; the conventional process is specifically: 125 grams of polyvinyl alcohol raw materials were soaked in 800 grams of aqueous solution for at least half an hour and stirred, heated to about 90°C, kept warm until dissolved, and filtered to form a polyvinyl alcohol solution; cooled to 80°C-85°C, in polyvinyl alcohol Add 18 grams of sulfuric acid to the vinyl alcohol solution, and stir it to form a mixed solution; add 50 grams of 37% formaldehyde to the mixed solution, keep it at 78°C-80°C, and make it into a white sticky shape after stirring material, the reaction is terminated; add 6 grams of sodium hydroxide to neutralize, and stir to below 40 ° C, which is the finished product. 2) After the process of washing and removing resi...

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Abstract

A blocking agent in the form of polyvinyl alcohol particles for the insertion therapy is prepared through condensation reaction of polyvinyl alcohol to obtain polyvinyl methyral, freezing, pulverizing, drying, sieving, and loading in bottles.

Description

technical field [0001] The invention relates to a production process of an embolic agent, in particular to a production process of a polyvinyl alcohol particle embolic agent. Background technique [0002] At present, in medical technology, as interventional therapy becomes more and more mature, the frequency of use is also increasing. Interventional medicine is the third major clinical discipline after internal medicine and surgery. Interventional therapy is not only different from "taking medicine and injection" in internal medicine, but also different from "surgery" in surgery. Instead, it is guided by high-definition medical imaging equipment. The catheter is inserted into the tumor site in the human body through a small incision, and then anti-tumor drugs are perfused through the blood supply artery or the blood supply of the tumor tissue is blocked, so that the tumor can be necrotic and shrunk in a short time to achieve the purpose of treatment. Due to the advantages o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/02A61K47/32
Inventor 郑隆泗
Owner 郑隆泗