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A preparation process and technology of Rehmannia glutinosa are applied in the preparation process of Qiju Dihuangxin and the field of preparation thereof, which can solve the problems of loss of effective components, small dosage, loss of volatile components and the like, and achieves convenient taking and carrying, small dosage, and satisfying drug use. desired effect

Inactive Publication Date: 2005-01-19
毛友昌
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But making a general survey of the technology and preparations of the above-mentioned products all have weak points: (1) Qiju Dihuang Capsules (included in the fourth volume of Chinese medicine prescription preparations of the Ministry of Health of the People's Republic of China) its technology is: Cortex Moutan, Chinese yam, zebra The four flavors of diarrhea and poria cocos are crushed into fine powder; wolfberry, rehmannia glutinosa, dogwood, and chrysanthemum are boiled with water, concentrated into a thick paste, mixed with the above fine powder, dried, crushed, and packed into capsules
The capsule is partly powdered and partly water-extracted. Although the prescription amount of the capsule is reduced by nearly half compared with that of Qiju Dihuang Pill, it still needs to take 5-6 capsules each time. , some water-insoluble components in dogwood, chrysanthemum, etc. are difficult to extract, and some volatile components are easy to lose during the decoction and concentration process
(2) Qiju Dihuang Tablets (already included in the fifth volume of Chinese medicine prescription preparations of the Ministry of Health of the People's Republic of China), its process is similar to that of capsules, part of which is powdered, part of which is decocted and extracted, and the prescription amount for one dose is based on the pill. It has been reduced by more than half, and its advantages and disadvantages are the same as those of capsules
Because of the clarification problem to be considered, the five flavors of rehmannia glutinosa, medlar, Chinese yam, Alisma, and dogwood in the oral liquid process adopt the water extraction and alcohol precipitation process, but the alcohol precipitation process solves the clarification problem of the oral liquid and also causes some problems. Loss of active ingredients (such as polysaccharides)
[0004] To sum up, although there are many dosage forms of Qiju Dihuang at present, they can not only fully retain the active ingredients of the prescription Chinese medicinal materials to ensure the curative effect, but also achieve exquisite preparation and small dosage, which can fully reflect the modernization of traditional Chinese medicine preparations. say no

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1: Preparation of Qiju Dihuang Capsules

[0036] The eight herbs are selected separately, impurities are removed, and the inspection is qualified for later use; the eight herbs are respectively crushed into coarse powder for later use; the cortex of Moutan and chrysanthemum are respectively added with water to distill, and paeonol and volatile oil are extracted, dissolved in an appropriate amount of absolute ethanol for later use; The distilled aqueous solution is ultrafiltered for later use; Cornus officinalis and medlar are extracted twice with 70% ethanol, the extracts are combined, ultrafiltered, and the ethanol is recovered from the filtrate for later use; Poria cocos is soaked twice in warm water, the extracts are combined, ultrafiltered, and the filtrate is used for later use; Rehmannia glutinosa , Chinese yam, and Alisma alisma, add water and decoct 3 times, the first and second time are 2 hours each, and the third time is 1 hour. Combine the decoctions...

Embodiment 2

[0037] Embodiment 2: Preparation of Qiju Dihuang Capsules

[0038] Separately select the eight herbs, remove impurities, and pass the inspection for later use; respectively crush the eight herbs into coarse powder for later use; take the bark of Moutan and chrysanthemum and add water to distill them to extract paeonol and volatile oil to make -cyclodextrin inclusion compound The distilled aqueous solution is used for ultrafiltration; the dregs, Rehmannia glutinosa, Alisma, Cornus officinalis, and Lycium barbarum are extracted twice with 95% ethanol, the extracts are combined, ultrafiltered, and the filtrate is recovered with ethanol for later use; Poria cocos is soaked in water for 2 times , the leachate was combined, ultrafiltered, and the filtrate was set aside; the yam was decocted with water for 3 times, the first and second times were 2 hours each, and the third time was 1 hour. Add the same decoction during the second decoction, combine the decoction, ultrafiltration, th...

Embodiment 3

[0039] Embodiment 3: Preparation of Qiju Dihuang Tablets

[0040] Separately select the eight herbs, remove impurities, and pass the test for later use; crush the eight herbs into coarse powder for later use; add water and vacuum distillation to extract paeonol and volatile oil from Moutan cortex and chrysanthemum, and dissolve them in an appropriate amount of absolute ethanol Standby; the distilled aqueous solution is filtered for later use; Cornus officinalis, Lycium barbarum, the above-mentioned peony bark and chrysanthemum dregs are extracted twice with 90% ethanol, the extracts are combined, filtered, and the filtrate is recovered with ethanol for later use; Poria cocos is soaked in water twice, Filtrate the leaching solution, and reserve the filtrate for later use; decoct rehmannia glutinosa, yam, and Alisma 3 times with water, the first and second times for 2 hours each, and the third time for 1 hour. The dregs and Poria cocos extract are added to the same decoction dur...

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Abstract

The invention discloses a novel 'QiJu Dihuang' formulation and its preparation, characterized by the modification to the preparing process by using the novel medicament preparing technologies, which achieves the beneficial effects of good curative effect and small amount of administration. It can be used for treating vertigo, akoasm and photophobia.

Description

technical field [0001] The invention relates to the technical field of Chinese patent medicine preparation technology, in particular to the preparation technology of Qiju Dihuangxin and its preparation. Background technique [0002] The prescription of Qiju Dihuang Wan comes from the "Medical Grade Baojian" in the Qing Dynasty. It is composed of Liuwei Dihuang Wan, wolfberry fruit and chrysanthemum. It is a famous prescription in ophthalmology in traditional Chinese medicine. , Yingfengliulei, blurred vision and other diseases have a significant effect. The process of the pill is that the eight medicinal materials in the prescription are crushed into fine powder, and an appropriate amount of refined honey / honey water is added to make a large honeyed pill / water honeyed pill. Because all the raw powders of the traditional Chinese medicines in the prescription are used as medicine, the dose of the pill is large, 9g for a large honeyed pill, and 6g for a ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K9/28A61P1/14A61P1/16
Inventor 毛友昌毛小敏
Owner 毛友昌
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