Preparation process for ginsenoside Rb1

A kind of ginsenoside, the technology of preparation process, applied in the preparation field of ginsenoside monomer

Inactive Publication Date: 2005-01-19
云南特安呐制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Ginsenoside Rb 1 The preparation

Method used

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Examples

Experimental program
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Effect test

Embodiment

[0015] Get 1.2kg of Panax notoginseng total glycosides and dissolve them with 25% ethanol, and the solution is absorbed by 30kg of pretreated D-101 macroporous resin, then rinse the resin column with 25% ethanol, wash the ginseng triol type saponins, and then use 60- Rinse the resin column with 80% ethanol, wash off the ginseng diol saponins, and then evaporate the dilute alcohol solution of ginseng diol saponins to dryness under reduced pressure to obtain about 650 g of ginseng diol saponins.

[0016] Weigh 200g of ginsengdiol-type saponins, heat and dissolve with 95% ethanol as little as possible, adsorb on 300g of 80-100 mesh silica gel, and dry below 60°C. Weigh 6kg of 200-300 mesh silica gel column, put the above crude silica gel adsorbed 200g diol type saponin on the upper part of 200-300 mesh silica gel column, carry out low pressure 0.5kg / cm 2 Dry column chromatography, elute with chloroform-methanol-water (7:3:1) lower layer solvent system, collect 500ml in each part,...

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PUM

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Abstract

The invention relates to a preparation process for ginsenoside monomer comprising the steps of, (1) dissolving total notoginseng saponin with alcohol, (2) passing through pretreated big hole resin columns, washing panaxatriol saponin with alcohol, rinsing the resin columns, (3) reclaiming alcohol through decompression to obtain panaxadiol saponin, (4) adsorbing on chromatographic silica gel, drying, (5) proceeding low pressure chromatography, (6) reclaiming solvent, vacuum drying to obtain the panaxoside Rb1 crude product, (7) repeating step 4-6 to obtain refined ginsenoside Rb1.

Description

technical field [0001] The invention relates to a preparation process of ginsenoside monomer. Background technique [0002] Chinese patent application CN1293198A (application number 00123074.3) discloses a "preparation method of rare ginsenosides", which is to dissolve alkali metal hydroxides in high-boiling point fatty alcohol compounds, and its concentration is generally 0.5%-50%, preferably The concentration is 3-15, continue to heat up under stirring to carry out alkali hydrolysis, the hydrolysis temperature is 180°C-270°C, the preferred temperature is 190-220°C After the reaction is completed, cool to room temperature and then add water to dilute, extract by organic solvent or large-pore size adsorption resin The product of the present invention is obtained by adsorption. Ginsenoside Rb 1 The preparation process has not been reported yet. Contents of the invention [0003] The purpose of the present invention is to provide a kind of ginsenoside Rb 1 preparation pr...

Claims

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Application Information

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IPC IPC(8): C07J9/00
Inventor 唐修文
Owner 云南特安呐制药股份有限公司
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