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Method for fabricating a nanoarray using the self-assembly of supramolecules and staining of metals

A supramolecular, self-assembly technology, applied in chemical instruments and methods, biochemical equipment and methods, nanotechnology, etc., can solve the problems of complex thin film structure, failure to develop diagnostic protein nanochips, and complex processes

Inactive Publication Date: 2005-02-02
KOREA ADVANCED INST OF SCI & TECH
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this method has the following disadvantages: its process is complicated, and the distance between patterns is still at the level of tens to one hundred nanometers
Moreover, the use of block copolymers has the following problems: the aspect ratio of the formed pattern is not large, the structure of the film is complicated, and it is not easy to give the structure orientation for the film
However, arrays formed by these methods still have voids ranging from tens of micrometers to several millimeters, and it has not been possible to develop highly integrated diagnostic protein nanochips with high densities of real-life samples while maintaining the three-dimensional structure of proteins.

Method used

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  • Method for fabricating a nanoarray using the self-assembly of supramolecules and staining of metals
  • Method for fabricating a nanoarray using the self-assembly of supramolecules and staining of metals
  • Method for fabricating a nanoarray using the self-assembly of supramolecules and staining of metals

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preparation example Construction

[0063] The preparation method of the DNA chip in the biological chip of the present invention includes the step of connecting the pre-prepared probes to the surface of the solid substrate by means of a spotting method. In this case, the amine-bound probe is dissolved in 1X to 7X, preferably 2X to 5X, more preferably 3X SSC buffer solution (0.45M NaCl, 15mM C 6 h 5 Na 3 o 7 , pH 7.0), and then use a microarray spotter to spot it onto the substrate with aldehyde groups attached. Then, the probes are immobilized on the substrate by utilizing the interaction between aldehyde groups and amine groups. The concentration of probe used is greater than 10 pmol / μl, preferably greater than 50 pmol / μl, more preferably greater than 100 pmol / μl. The amine group combined with the probe and the aldehyde group combined with the substrate react with each other for 4-8 hours, preferably 5-7 hours, most preferably about 6 hours under the condition of 70-90%, preferably 80%, in humidity, so tha...

Embodiment 1

[0067] Embodiment 1: the synthesis of supramolecular

[0068] The supramolecule of formula (1) used in the present invention is synthesized through the steps of the following reaction scheme (1). The scanning electron microscope analysis of the supramolecule confirmed that the supramolecule is a regular cylindrical structure of nanoscale or smaller scale.

[0069] (Reaction Diagram 1)

[0070]

Embodiment 2

[0071] Embodiment 2: substrate surface modification

[0072] In the present invention, a silicon wafer is used as a substrate. Metallic, non-metallic, or other thin films may be formed on the surface of the substrate, if desired.

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Abstract

A method for forming a nanopattern of supramolecules, which includes the steps of: forming a thin film of supramolecules on a substrate; self-assembling the supramolecules by annealing to form regular structures; selectively staining the formed regular structures with a metal; and etching the metal-selectively stained thin film to remove a portion of the thin film, which was not stained with the metal. Such method enables the fabrication of nanoarray devices in which bioreceptors are attached to the formed nanopattern of supramolecules on the substrate.

Description

technical field [0001] The invention relates to a method for generating nanometer-scale or smaller-scale graphics, which includes the following steps: generating a supramolecular film on a substrate, inducing supramolecular self-assembly through annealing to form a regular structure, and using metal pairs to form a regular structure. The regular structure described above is selectively colored, and the metallic colored film is etched. The present invention also relates to a method of preparing a nanochip, the method comprising the step of linking a bioreceptor to the formed supramolecular nanochip or substrate. Background technique [0002] Currently, the formation of surface patterns has been achieved by photolithography using polymer films as photoresists. However, using this method to prepare nanoscale, highly precise patterns has encountered many difficulties. This is due to the limitations of the wavelength of light that can be used, as well as the limitations of equip...

Claims

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Application Information

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IPC IPC(8): G01N37/00B01J19/00B01J20/26B01J20/28B82B3/00C07C69/94C12M1/00C12N15/09C12Q1/68C23F4/00G03G9/00H01L21/00
CPCC12Q1/6837B82Y5/00
Inventor 郑喜台权起暎李修林
Owner KOREA ADVANCED INST OF SCI & TECH
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