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Preparation method of L-ornithine hydrochloride

A technology of ornithine hydrochloride and arginine, applied in the field of preparation of L-ornithine hydrochloride, can solve the problem that the purity of the finished product is not high, the L-ornithine hydrochloride is difficult and difficult to purify and other problems to achieve the effect of simplifying the reaction operation steps

Inactive Publication Date: 2005-03-09
上海依福瑞实业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Using enzymatic methods, such as: Japan Kyowa Hakko Kogyo Co., Ltd. (KyowaHakko Kogyo Co., Ltd) patent JP53003586 discloses the use of fermentation to produce amino acids, with L-arginine as the starting material, which is gradually degraded by microbial fermentation. Microbial digestion to obtain L-ornithine hydrochloride, the microbial preparation used is a suspension of washed streptococcus culture metabolites, its disadvantages are: it is difficult and costly to quantitatively prepare L-ornithine hydrochloride , difficult to save
The disadvantage of this preparation method is that the purity of the finished product is not high, which contains more DL-ornithine hydrochloride, which is difficult to purify, and the optical purity is poor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Dissolve 500 grams of L-arginine in 5000 milliliters of water, add 15 grams of phase transfer catalyst crown ether and 50 grams of 30% milk of lime calcium hydroxide prepared in advance, stir and heat to 98° C. for reflux for two hours. Then add 8 grams of procatalyst choline, keep the temperature at 98° C. and continue to stir for two hours. After the reaction mixture was cooled to room temperature, it was acidified to pH 1.7 with 6N sulfuric acid, and filtered to remove calcium sulfate. After the filtrate is concentrated to a thin slurry under reduced pressure at ≥700mm / Hg, adjust the pH to 7.0-7.2 with saturated barium hydroxide solution, remove the barium sulfate precipitate by filtration, adjust the pH of the filtrate to 4.0-4.5 with 3N hydrochloric acid, and then Concentrate in vacuum at 700mm / Hg to a thin slurry, then add ethanol at a temperature of 30-35°C. After cooling for 8 hours, the crude L-ornithine hydrochloride crystals were filtered off. The crude pro...

Embodiment 2

[0009] Preparation process is identical with embodiment 1, but following parameter is different:

[0010] 1. Add 25 grams of phase transfer catalyst crown ether.

[0011] 2. The milk of lime calcium hydroxide modulation ratio is determined as 30% and the addition amount is 60 grams.

[0012] 3. The addition amount of cocatalyst choline is 10 grams.

[0013] 4. Cooling time increased to 12 hours.

[0014] The resulting product yield is 82%, the dry product content is 99.3%, and the specific rotation [α] D 20 +24.5°.

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PUM

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Abstract

A process for preparing L-ornithine hydrochloride includes dissolving L-arginine in water, adding crown ether and calcium hydroxide, stirring while heating, adding choline, reaction, cooling, using sulfuric acid to regulate pH value, filtering to remove calcium sulfate, vacuum concentrating, using saturated solution of barium hydroxide to regulate pH value, filtering to remove barium sulfate, using hydrochloric acid to regulate pH value, vacuum concentrating, adding alcohol, cooling and filtering. It has high output rate and purity.

Description

Technical field: [0001] The invention relates to a method for preparing L-ornithine hydrochloride, in particular to a method for preparing L-ornithine hydrochloride by chemical synthesis. Background technique: [0002] The existing method for preparing L-ornithine hydrochloride uses L-arginine which has realized industrial production as a starting material, and adopts an enzymatic method or a chemical synthesis method to prepare it. Using enzymatic methods, such as: Japan Kyowa Hakko Kogyo Co., Ltd. (KyowaHakko Kogyo Co., Ltd) patent JP53003586 discloses the use of fermentation to produce amino acids, with L-arginine as the starting material, which is gradually degraded by microbial fermentation. Microbial digestion to obtain L-ornithine hydrochloride, the microbial preparation used is a suspension of washed streptococcus culture metabolites, its disadvantages are: it is difficult and costly to quantitatively prepare L-ornithine hydrochloride , Preservation is difficult. U...

Claims

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Application Information

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IPC IPC(8): C07C227/16C07C229/26
Inventor 许云生许迎春高增达虞人杰
Owner 上海依福瑞实业有限公司
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