Extraction of oligomeric anthocyanin from pine bark

A technology of proanthocyanidins and oligomers, which is applied in pharmaceutical formulations, unknown raw materials, medical preparations containing active ingredients, etc., can solve problems such as environmental pollution and low energy consumption, and achieve the effect of simple process

Inactive Publication Date: 2005-05-11
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method consumes less energy and is suitable for industrial production, but it brings environmental pollution problems due to the use of the more toxic organic solvent chloroform

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Weigh 100 grams of 60-mesh pine bark powder and put it into a constant temperature extractor, add 300 grams of petroleum ether for degreasing treatment, the degreasing temperature is controlled at 40°C, filter after 1 hour of degreasing, and put the obtained filter residue as raw material powder into the constant temperature extractor , then add petroleum ether according to the weight ratio of raw material powder and petroleum ether 1:3, repeat the above process for the second degreasing treatment, and obtain the degreased raw material powder. Then adopt ethyl acetate to extract the raw material powder after degreasing, feed intake according to the weight ratio of raw material powder and solvent ethyl acetate 1: 3, after extracting at 50 ℃ for 1 hour, filter to obtain ethyl acetate extract and filter residue, and then The filter residue was used as raw material powder, and ethyl acetate was added to repeat the extraction process once. The filtrates after the two extract...

Embodiment 2

[0018] Weigh 100 grams of 150-mesh pine bark powder and put it into a constant temperature extractor, add 300 grams of petroleum ether for degreasing treatment, the degreasing temperature is controlled at 70°C, filter after 1 hour of degreasing, and put the obtained filter residue as raw material powder into the constant temperature extractor In the process, petroleum ether was added according to the weight ratio of raw material powder and petroleum ether at 1:3, and the above process was repeated for the second degreasing treatment, and the degreasing treatment was performed a total of 3 times in the above-mentioned manner to obtain the degreased raw material powder. Then adopt ethyl acetate to extract the raw material powder after degreasing, feed intake according to the weight ratio of raw material powder and solvent ethyl acetate 1: 3, after extracting at 70 ℃ for 1 hour, filter to obtain ethyl acetate extract and filter residue, and then The filter residue was used as raw ...

Embodiment 3

[0021] Weigh 100 grams of 100-mesh pine bark powder and put it into a constant temperature extractor, add 300 grams of petroleum ether for degreasing treatment, the degreasing temperature is controlled at 60°C, filter after 1 hour of degreasing, and put the obtained filter residue as raw material powder into the constant temperature extractor , then add petroleum ether according to the weight ratio of raw material powder and petroleum ether 1:3, repeat the above process for the second degreasing treatment, and obtain the degreased raw material powder. Then adopt ethyl acetate to extract the raw material powder after degreasing, feed intake according to the weight ratio of raw material powder and solvent ethyl acetate 1: 3, after extracting at 60 ℃ for 1 hour, filter to obtain ethyl acetate extract and filter residue, and then The filter residue was used as raw material powder, and ethyl acetate was added to repeat the above extraction process, and in this way, a total of 3 extr...

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Abstract

Extraction of oligomeric protocyanidin from pine barks is carried out by: extracting it from raw pine bark powders with a polar organic solvent at first to obtain extracting liquid containing it richly, adding anti-solvent to deposit it out, and separating solid from liquid to obtain deposited products. Petroleum ether or sulfuric ether is used as solution to remove grease and as anti-solvent. Ethyl acetate or ethanol is used as extracting solution. It is simple, saves energy, and has neither pollution nor much investment. Its products can be used in food, cosmetics or medicines as anti-oxidizing agent.

Description

technical field [0001] The invention relates to a method for extracting oligomeric proanthocyanidins from pine bark. An oligomeric proanthocyanidin (OPC) product is obtained by adding an antisolvent to the extract and directly precipitating, which belongs to the field of natural product extraction. Background technique [0002] Oligomeric proanthocyanidins (OPC) are polyphenolic compounds, which are polymerized from catechin and epicatechin. Because the molecules of this kind of substances have many electronic hydroxyl sites, they have strong antioxidant capacity, free radical scavenging ability and special improvement effect on human microcirculation. According to reports, the antioxidant capacity of OPC in the body is It is 50 times that of vitamin E and 20 times that of vitamin C. It is widely used in food, cosmetics, and medicine. Oligomeric proanthocyanidins widely exist in natural plants, such as grapes, sea buckthorn, apples, sorghum, legumes, pine bark, etc. Among ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/62
Inventor 于文利赵亚平
Owner SHANGHAI JIAO TONG UNIV
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