Non-gelatinous capsule film compositions and capsules using the same

一种组合物、胶凝的技术，应用在非有效成分的医用配制品、胶囊输送、微型胶囊等方向，能够解决降低存储稳定性、胶囊壳龟裂或软化、胶囊易碎吸湿性/释放性等问题，达到高强度、易于崩解、佳存储稳定性的效果

Inactive Publication Date: 2005-05-11
MORISHITA JINTAN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, such capsules are friable and have increased hygroscopicity / release properties, which cause the capsule shell to crack or soften and become sticky, thereby reducing its storage stability

Method used

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  • Non-gelatinous capsule film compositions and capsules using the same
  • Non-gelatinous capsule film compositions and capsules using the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] The capsule shell components shown in Table 1 were mixed to prepare a non-gelled capsule shell composition. MCTs (medium chain triglycerides) shown in Table 1 were prepared as the contents of the capsules.

[0058] The shell composition and contents are used as figure 1 The shown machine 100 for preparing seamless capsules prepares the capsule 10 of the present invention having a double structure in which the contents 12 are contained in the capsule shell 11 according to the following method. The non-gelled capsule shell composition of the present invention heated to 70° C. is sprayed through the outer nozzle of a concentric double nozzle and simultaneously sprays the contents through its inner nozzle, thereby forming a dual and then release the jet into a cooled solution (vegetable oil cooled to a temperature not higher than 20° C.), thereby obtaining the seamless capsule of the present invention. After drying the resulting capsules in a forced air circulation oven a...

Embodiment 2

[0078] The same method as described in Example 1 was used to prepare the seamless capsule of the present invention, except that the capsule shell and content formulations shown in Table 2 were used. The obtained capsule 10 had a particle diameter φ of 2 mm and a capsule shell thickness of 85 μm.

[0079] Table 2

[0080] Composition Quantity

[0081] (shell)

[0082] Matrix:

[0083] Soluble starch (Stabilose TA-13)** 15.2% by weight

[0084] Gelling agent:

[0085] κ-Carrageenan 2.3% by weight

[0086] Locust bean gum 0.1% by weight

[0087] Shell Enhancer:

[0088] Glycerin 4.5% by weight

[0089] Gelling aids:

[0090] Potassium chloride 0.4% by weight

[0091] Purified water 77.5% by weight

[0092] 22.5% solids

[0093] (inclusions)

[0094] MCT (Medium Chain Triglycerides) 100% by weight

[0095] **: Commercially available from Matsutani Chemical Industry Co., Ltd.; average molecular weight = 20,000 to 30,000; DE = about 1.

Embodiment 3

[0097] The same method as described in Example 1 was used to prepare the seamless capsule of the present invention, except that the capsule shell and content formulations shown in Table 3 were used. The obtained capsule 10 had a particle diameter φ of 2 mm and a capsule shell thickness of 85 μm.

[0098] table 3

[0099] Composition Quantity

[0100] (shell)

[0101] Matrix:

[0102] Soluble starch (Stabilose TA-13)** 14.1% by weight

[0103] Gelling agent:

[0104] Furcellan 2.3% by weight

[0105] Locust bean gum 0.1% by weight

[0106] Shell Enhancer:

[0107] Glycerin 5.6% by weight

[0108] Gelling aids:

[0109] Potassium chloride 0.4% by weight

[0110] Purified water 77.5% by weight

[0111] 22.5% solids

[0112] (inclusions)

[0113] MCT (Medium Chain Triglycerides) 100% by weight

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Abstract

Non-gelatinous capsule film compositions containing as the base a starch hydrolyzate having an average DE of less than 10 and an average molecular weight of not more than 30,000. These non-gelatinous capsule film compositions have stable moisture absorbing / releasing properties and strength to such extent as sufficiently withstanding the production and storage as products and yet achieve excellent disintegration properties in vivo. Also, capsules produced by using the non-gelatinous capsule film compositions as described above are provided.

Description

technical field [0001] The present invention relates to a non-gelled capsule shell composition for food, medicine, quasi-drug, etc. and capsules formed therefrom. Background technique [0002] As a shell material for capsules used for foods, drugs, quasi-drugs, etc., gelatin is mainly used because it can be rapidly disintegrated in the body, has high shell strength, and stable moisture absorption / release properties. [0003] However, since gelatin is animal protein obtained from livestock such as cattle, pigs, poultry, etc., it is difficult to contain a substance that can react with the protein as a capsule component therein. Gelatin shells tend to be insoluble when moisture increases or become brittle over time, and their reduced heat resistance is also a problem. In some cases, its use has been limited due to allergic reactions to ingestion of gelatin, religious reasons or vegetarianism. Furthermore, recently, it has been difficult to use gelatin due to livestock disease...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K9/50
CPCA61K9/4816A61K9/4858A61K9/5036Y10T428/2982Y10T428/2984A61K47/36A61K47/26A61K9/48
Inventor 釜口良诚盐见隆史上原泰夫
Owner MORISHITA JINTAN CO LTD
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