Flunarizine hydrochloride injection and its preparing method
A technology of flunarizine hydrochloride and injection, which is applied in the fields of blood diseases, medical formulas, extracellular fluid diseases, etc. It can solve the problems of not containing solubilizers and analgesics, etc., and achieve remarkable curative effect and convenient use
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Embodiment 1
[0026] Accurately weigh 0.5 g of flunarizine hydrochloride, add 500 ml of water for injection at 10 degrees Celsius, and stir to disperse evenly. Heat to 100 degrees Celsius, add 0.1‰ activated carbon and keep it warm for 15 minutes, filter while it is hot, dilute the filtrate with water for injection to 1000ml, fine filter until clear, add appropriate amount of sodium hydroxide to adjust the pH to 3.5, after the semi-finished product is qualified, potting, 5ml per bottle, sterilized by circulating steam at 100°C for 30 minutes. Specifications: 5ml: 2.5mg. It can be added to 5% or 10% glucose injection for intravenous infusion.
Embodiment 2
[0028] Accurately weigh 0.25 g of flunarizine hydrochloride, add 500 ml of 5% glucose aqueous solution at 20 degrees Celsius, and stir to disperse evenly. Heat to 80 degrees Celsius, add 0.1‰ activated carbon to keep warm for 15 minutes, filter while it is hot, directly add 5% glucose aqueous solution to the filtrate to dilute to 1000ml, fine filter until clear, add appropriate amount of sodium hydroxide to adjust the pH to 3.5, after the semi-finished product is qualified, pour Sealed, 5ml per bottle, sterilized by circulating steam at 100°C for 30 minutes. Specifications: 5ml: 1.25mg. It can be added to 5% or 10% glucose injection for intravenous infusion.
Embodiment 3
[0030] Accurately weigh 0.5 g of flunarizine hydrochloride, add 500 ml of water for injection at 40 degrees Celsius, and stir to disperse evenly. Heat to 60 degrees Celsius, add 0.1‰ activated carbon to keep warm for 15 minutes, filter while it is hot, dilute the filtrate with water for injection to 1000ml, fine filter until clear, add an appropriate amount of sodium hydroxide solution to adjust the pH to 3.0, after the semi-finished product is tested, pour Sealed, 5ml per bottle, sterilized by circulating steam at 100°C for 30 minutes. Specifications: 5ml: 2.5mg. It can be added to 5% or 10% glucose injection for intravenous infusion.
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