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Northern bean root soft capsule and its preparation process

A technology of Beidougen and soft capsules, applied in the field of Beidougen soft capsules and preparation thereof, can solve the problems that sugar-coated tablets are unfavorable for diabetic patients to take, disintegrate, slow in absorption, unstable in quality, etc., and achieves easy operation for determination and characterization. , Overcome the splinter, the effect of stable product quality

Inactive Publication Date: 2005-08-10
辽宁大生商贸有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The main active ingredient in the bean root is the total alkaloids of the bean root. Tablets and hard capsules are common dosage forms. However, there are problems common to tablets, such as a large amount of dust during coating; splits, discoloration, and unstable quality during storage; disintegration and absorption are slow, and the curative effect is affected; at the same time, sugar-coated tablets are not conducive to taking by diabetics.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Composition Parts (by weight)

[0022] 1 serving of medicine

[0023] Glycerin 0.05 part

[0024] Tween-80 0.02 servings

[0025] Polyethylene Glycol-400 0.92 servings

[0026] Propylparaben 0.01 part

[0027] Preparation of matrix: take 920 g of polyethylene glycol-400, add 50 g of glycerol, 20 g of Tween, and 10 g of propylparaben, and mix them evenly to obtain a total of 1000 g of soft capsule matrix.

[0028] The northern bean root extract and the above-mentioned matrix are mixed evenly, compressed into soft capsules, and dried to obtain the final product.

Embodiment 2

[0030] Composition Parts (by weight)

[0031] 1 serving of medicine

[0032] Isopropyl alcohol 0.308 parts

[0033] Polyethylene Glycol-400 0.86 parts

[0034] Inositol 0.015 servings

[0035] Malic acid 0.015 part

[0036] Sorbitol 0.002 servings

[0037] Preparation of matrix: take 860 g of polyethylene glycol-400, add 308 g of isopropanol, 15 g of inositol, 15 g of malic acid, and 2 g of sorbitol, mix well, and obtain a total of 1200 g of soft capsule matrix.

[0038] The northern bean root extract and the above-mentioned matrix are mixed evenly, compressed into soft capsules, and dried to obtain the final product.

Embodiment 3

[0040] Composition Parts (by weight)

[0041] 1 serving of medicine

[0042] Macrogol-400 1.38 servings

[0043] Tween-80 0.05 servings

[0044] Ethyl hydroxyethyl cellulose 0.02 part

[0045] Dibutylhydroxytoluene 0.045 part

[0046] Parahydroxybenzoic acid 0.005 part

[0047] Preparation of substrate Ethyl hydroxyethyl cellulose: take 1380 g of polyethylene glycol-400, add 50 g of Tween-80, 20 g of ethyl hydroxyethyl cellulose, 45 g of dibutyl hydroxytoluene, 5 g of p-hydroxybenzoic acid, and mix Evenly, a total of 1500 g of soft capsule matrix was obtained.

[0048] The northern bean root extract and the above-mentioned matrix are mixed evenly, compressed into soft capsules, and dried to obtain the final product.

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PUM

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Abstract

A moonseed rhizome capsule features that its core is prepared from moonseed rhizome and medical auxiliary. Its preparing process is also disclosed.

Description

[Technical field] [0001] The invention relates to Beidougen soft capsules and a preparation process thereof. [Background technique] [0002] Beidougen is a traditional Chinese medicine for clearing away heat and detoxification, scientifically known as bat ge. [0003] The main active ingredient in Beidougen is the total alkaloids of Beidougen. Tablets and hard capsules are common dosage forms. However, Beidougen tablets are compressed into tablets from solid powder or granules containing drugs, coated with sugar or film, and formed into tablets. There are common problems with tablets, such as large amount of dust generated during coating; splintering, discoloration, and unstable quality during storage; . The characteristics of the soft capsule dosage form are that the drug disperses quickly in the gastrointestinal tract and absorbs well. It has higher bioavailability than tablets and hard capsules, and its dissolution rate is much better than that of the same variety of ta...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61P11/00A61P11/04
Inventor 王艳
Owner 辽宁大生商贸有限公司
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