Amino acid accelerated CuI catalyzed aryl halide and coupling reaction of alkyl sulfonate
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
- Publication Date
- 2005-08-10
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
technical field
[0001] The invention relates to a method for carrying out coupling reaction of aryl halide and hydrocarbyl sulfinate under the condition of using amino acid as additive and CuI as catalyst. Through this method, the reaction of preparing aryl sulfone from a series of aryl halides and the reaction of preparing heteroaryl sulfone from heterocyclic aromatic halides containing nitrogen, oxygen and sulfur are realized. Background technique
[0002] Aryl sulfone has its special chemical properties and biological activity, and the structure of aryl sulfone can be found in many drugs. As an important class of organic compounds, their synthesis and application have been extensively studied. The more commonly used synthesis methods of aryl sulfones are: oxidation of corresponding aryl sulfides, sulfonation of aromatic hydrocarbons under acid catalysis, reaction of organolithium, organomagnesium compounds and sulfone esters; and palladium catalyzed hydrocarbyl sulfinate...