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Method for extracting general iridoid glycoside from 'Duyiwei' of Tibet medicine and application

A technology of total iridoid glycosides and an extraction method, which are applied in the field of extracting total iridoid glycosides from the unique flavor of Tibetan medicine and their application fields, and achieve the effects of promoting blood coagulation and shortening bleeding time.

Active Publication Date: 2005-08-31
中国人民解放军联勤保障部队第九四〇医院
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Problems solved by technology

[0004] For the extraction and separation of water-soluble components of natural products, the macroporous resin adsorption method is a very effective industrial production method, but the industrial production method of using a macroporous adsorption resin column to extract total iridoid glycosides from unique medicines, At present, there are no relevant literature and patent reports at home and abroad

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  • Method for extracting general iridoid glycoside from 'Duyiwei' of Tibet medicine and application

Examples

Experimental program
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Effect test

Embodiment 1

[0044]Embodiment 1: get 5 kg of the above-ground part of Duyiwei as raw material, pulverize it, cross a 20-mesh sieve, add 25000 ml of ethanol with a volume percentage concentration of 70% at 50 ° C, stir and extract for 3 hours, filter, Add 25,000ml of ethanol with a volume percentage concentration of 70% to the dregs (repeatedly extract 3 times), combine the filtrates, concentrate the filtrate under reduced pressure to an extract, then dissolve it with 10,000ml hot water at 60°C, and filter to remove the precipitate after cooling . 4.5kg of the mother liquor has been eluted with ethanol (eluted with 95% ethanol until the ethanol eluent plus distilled water does not appear turbid, and then eluted the column with distilled water until there is no alcohol smell.) Polyamide (14 -30 mesh) column, the loading speed is 10ml / min, the polyamide column is washed with 30000ml of distilled water (flow rate is 10000ml / hour), and the mother liquor and water eluent flowing out from the pol...

Embodiment 2

[0045] Embodiment two, take 5 kg of the aboveground part of Duyiwei as raw material, pulverize it, pass through a 20 mesh sieve, add 25000 ml of ethanol with a volume percentage concentration of 30%, soak it warmly at 70 ° C, stir and extract for 2 hours, filter, Add 25,000ml of ethanol with a volume percentage concentration of 30% to the dregs (repeatedly extract 3 times), combine the filtrates, concentrate the filtrate under reduced pressure to an extract, then dissolve it in 10,000ml of hot water at 30°C, and filter to remove the precipitate after cooling . 4.5kg of the mother liquor has been eluted with ethanol (eluted with 95% ethanol until the ethanol eluent plus distilled water does not appear turbid, and then eluted the column with distilled water until there is no alcohol smell.) Polyamide (14 -30 mesh) column, the loading speed is 10ml / min, the polyamide column is washed with 30000ml of distilled water (flow rate is 10000ml / hour), and the mother liquor and water elue...

Embodiment 3

[0046] Embodiment three: get 5kg of above-ground part of Duyiwei as raw material, pulverize it, pass through a 20 mesh sieve, add 25000ml of ethanol with a volume percentage concentration of 50% at 20°C for warm soaking, stir and extract for 3 hours, filter, Add 25,000ml of ethanol with a volume percentage concentration of 70% to the medicinal residues (repeatedly extract 3 times), combine the filtrates, concentrate the filtrates under reduced pressure to an extract, then dissolve them in 10,000ml of 90°C hot water, and filter to remove the precipitate after cooling . 4.5kg of the mother liquor has been eluted with ethanol (eluted with 95% ethanol until the ethanol eluent plus distilled water does not appear turbid, and then eluted the column with distilled water until there is no alcohol smell.) Polyamide (14 -30 mesh) column, the loading speed is 10ml / min, the polyamide column is washed with 30000ml of distilled water (flow rate is 10000ml / hour), and the mother liquor and wa...

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Abstract

A process for extracting the iridoid glycoside from common lamiophlomis herb includes reflux extracting in alcohol solution, macroreticular resin adsorpotion, and separation. Said iridoid glycoside can be used as the active staltic component.

Description

technical field [0001] The present invention relates to an extraction process of effective components of Chinese herbal medicines, in particular to a process for extracting total iridoid glycosides from Tibetan medicine unique herb, and at the same time, the invention also relates to the application of the extract as a hemostatic active component. Background technique [0002] Duyiwei is the whole herb or root of Lamiophlomis rotata (Benth.) Kudo, a plant of the genus Lamiophlomis rotata (Benth.) Kudo. It tastes bitter, slightly cold, slightly poisonous, and after a long time in the mouth, it will turn gold like earth, and has a sense of numbness. "Jingzhu Materia Medica" records "solidify the essence and drain yellow water". "Qinghai-Tibet Plateau Drug Illustrated Book" records "replenishing marrow, stopping bleeding, treating edema, yellow water, joint jaundice, and inflammation of spongy bone". [0003] The drug developed with the Tibetan medicine Duyiwei as the main co...

Claims

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Application Information

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IPC IPC(8): A61P7/04C07H1/08
Inventor 贾正平李茂星张汝学
Owner 中国人民解放军联勤保障部队第九四〇医院
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