Anti-cancer compound preparation of giant knotweed, Tengli root and thinleaf adina root and its making method and use

A technology of compound Polygonum cuspidatum and Polygonum cuspidatum root, which is applied in the direction of antineoplastic drugs, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve the problems of separation methods and preparation technologies that have not been reported, and achieve improved bioavailability and improved Transfer rate, the effect of facilitating industrial production

Inactive Publication Date: 2005-10-12
SOUTH CHINA UNIV OF TECH
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  • Abstract
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Problems solved by technology

[0006] There are no relevant reports on the macroporous resin separation method and preparation technology of

Method used

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  • Anti-cancer compound preparation of giant knotweed, Tengli root and thinleaf adina root and its making method and use

Examples

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[0026] Example 1

[0027] Polygonum cuspidatum root 2Kg, vine pear root 1Kg, and Salicaria root 1Kg, crushed into coarse powder, add 40L boiling water at 100°C, time to extract for 90 minutes, keep heating during the period and maintain a slight boiling state. After filtering, add 20L of 100°C boiling water to the filter residue, and leaching for 60 minutes at a timing. During this time, keep heating and maintain a slightly boiling state. Filter, discard the filter residue, combine the two filtrates, and concentrate the filtrate under constant pressure to a thermal specific gravity of 1.05, add 4g of flocculant chitin, stir and centrifuge (3000 rpm, 10 minutes), save the supernatant, and adjust with 10% HCl pH to 2, stand, centrifuge to remove precipitation (the same conditions as above), the supernatant is passed through the macroporous resin HPD100, and the effective components of the adsorbed medicinal materials are eluted with 70% ethanol aqueous solution. The eluent is decomp...

Example Embodiment

[0028] Example 2

[0029]Polygonum cuspidatum root 5Kg, vine pear root 1Kg, and Salmon root 1Kg were pulverized into coarse powder, added with 84L boiling water at 100°C, and leached at a time for 120 minutes. During this time, heating was maintained to maintain a slight boiling state. After centrifugation (3000 rpm, 10 minutes), the filter residue was added to 41L of boiling water at 100°C, and timed to extract for 120 minutes. During this time, heating was maintained to maintain a slight boiling state. Centrifuge (3000 rpm, 15 minutes), discard the filter residue, combine the two centrifugal liquids, add 70 g of flocculant gelatin, filter after stirring, adjust the pH of the filtrate to 5 with 5% HCl, let stand, filter to remove precipitation, and supernatant After the liquid passes through the macroporous resin HPD300, the active ingredients of the adsorbed medicinal materials are eluted with 80% acetone aqueous solution. The eluate is decompressed to recover ethanol. The vacuu...

Example Embodiment

[0030] Example 3

[0031] Polygonum cuspidatum root 3Kg, vine pear root 2Kg, and Salicaria root 1Kg are crushed into coarse powder, add 48L of boiling water at 100°C, and extract at a time for 60 minutes. Keep heating during the period to maintain a slight boiling state. After filtering, add 24L of 100°C boiling water to the filter residue, and time to extract for 60 minutes. During this time, keep heating and maintain a slightly boiling state. After filtering, add 24L of 100°C boiling water to the filter residue, and time to extract for 60 minutes. During this time, keep heating and maintain a slightly boiling state. Filter, discard the filter residue, combine the three filtrates, concentrate the filtrate under reduced pressure to a thermal specific gravity of 1.05 (vacuum greater than 0.04Mpa), add 30g of ZTC flocculant produced by Tianjin Zhengtiancheng Clarification Technology Co., Ltd., stir and centrifuge (3000 rpm) , 10 minutes), save the supernatant, adjust the pH to 3 wit...

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Abstract

An antineoplastic Chinese medicine in the form of tablet or capsule for treating and preventing intestinal cancer, stomach cancer, etc is prepared from the giant knotweed rhizome, thin leaf adina root, etc through pulverizing, proportional mixing, extracting in hot water, flocculating deposition, filtering or centrifugal separating, regulating pH value, adsorbing eluting, vacuum concentrating, drying, pulverizing and shaping.

Description

technical field [0001] The invention relates to a compound Chinese herbal medicine preparation, in particular to an anti-tumor compound Chinese herbal medicine preparation and its preparation method and application. Background technique [0002] The compound three-root prescription mainly includes Polygonum cuspidatum root, Tengli root and Salicymus root, which are derived from empirical prescriptions, and their proportions are equal proportions (Yu Rencun, Commonly Used Prescriptions for Tumors, Oncology of Traditional Chinese Medicine, 1997: 21). In the treatment of gastrointestinal tumors, it is suggested that it has a significant anti-tumor effect (Bao Suzhen, Sun Zaidian, etc., 120 cases of advanced colorectal cancer treated with traditional Chinese medicine compound Sangen decoction combined with chemotherapy, Liaoning Journal of Traditional Chinese Medicine, 1992 (7): 33-34), However, the active ingredients are not clear and have not been fur...

Claims

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Application Information

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IPC IPC(8): A61P35/00
Inventor 叶勇
Owner SOUTH CHINA UNIV OF TECH
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