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Anti-cancer compound preparation of giant knotweed, Tengli root and thinleaf adina root and its making method and use

A technology of compound Polygonum cuspidatum and Polygonum cuspidatum root, which is applied in the direction of antineoplastic drugs, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve the problems of separation methods and preparation technologies that have not been reported, and achieve improved bioavailability and improved Transfer rate, the effect of facilitating industrial production

Inactive Publication Date: 2005-10-12
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] There are no relevant reports on the macroporous resin separation method and preparation technology of Polygonum cuspidatum root, rattan pear root, salicyme root and their prescription active ingredients or parts

Method used

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  • Anti-cancer compound preparation of giant knotweed, Tengli root and thinleaf adina root and its making method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 2Kg of Polygonum cuspidatum root, 1Kg of Tengli root, and 1Kg of Myrica rubra root are crushed into coarse powder, added with 40L of boiling water at 100°C, and timed for 90 minutes of leaching, during which time heating is maintained to maintain a slight boiling state. Filter, add 20L of boiling water at 100°C to the filter residue, and time leaching for 60 minutes, keep heating during the period, and maintain a slight boiling state. Filter, discard the filter residue, combine the filtrate twice, concentrate the filtrate to a thermal specific gravity of 1.05 under normal pressure, add 4 g of flocculant chitin, centrifuge after stirring (3000 rpm, 10 minutes), keep the supernatant, and adjust it with 10% HCl. pH to 2, stand still, centrifuge to remove precipitation (same conditions as above), the supernatant passes through the macroporous resin HPD100, and the active ingredients of the adsorbed medicinal materials are eluted with 70% ethanol aqueous solution, and the elu...

Embodiment 2

[0029]5Kg of Polygonum cuspidatum root, 1Kg of Tengli root, and 1Kg of Myrica rubra root are crushed into coarse powder, added with 84L of boiling water at 100°C, and timed for 120 minutes of leaching, during which time heating is maintained to maintain a slightly boiling state. Centrifuge (3000 rpm, 10 minutes), add 41L of 100°C boiling water to the filter residue, and time leaching for 120 minutes, during which heating is maintained to maintain a slightly boiling state. Centrifuge (3000 rpm, 15 minutes), discard the filter residue, combine the centrifuged liquid twice, add flocculant gelatin 70g, filter after stirring, adjust the pH of the filtrate to 5 with 5% HCl, let it stand, filter to remove the precipitate, supernatant The liquid passes through the macroporous resin HPD300, and the active ingredients of the adsorbed medicinal materials are eluted with 80% acetone aqueous solution. The eluent is decompressed to recover ethanol, the vacuum degree is greater than 0.04Mpa, ...

Embodiment 3

[0031] 3Kg of Polygonum cuspidatum root, 2Kg of Tengli root, and 1Kg of Myrica rubra root were crushed into coarse powder, added with 48L of boiling water at 100°C, and leached for 60 minutes at a time, during which heating was maintained to maintain a slight boiling state. Filter, add 24L of boiling water at 100°C to the filter residue, and time leaching for 60 minutes, keep heating during the period, and maintain a slightly boiling state. Filter, add 24L of boiling water at 100°C to the filter residue, and time leaching for 60 minutes, keep heating during the period, and maintain a slightly boiling state. Filter, discard the filter residue, merge the filtrate three times, the filtrate is concentrated under reduced pressure to thermal specific gravity 1.05 (vacuum tightness is greater than 0.04Mpa), adds ZTC flocculant 30g produced by Tianjin Zhengtiancheng Clarification Technology Co., Ltd., centrifuges after stirring (3000 rpm , 10 minutes), retain the supernatant, adjust t...

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Abstract

An antineoplastic Chinese medicine in the form of tablet or capsule for treating and preventing intestinal cancer, stomach cancer, etc is prepared from the giant knotweed rhizome, thin leaf adina root, etc through pulverizing, proportional mixing, extracting in hot water, flocculating deposition, filtering or centrifugal separating, regulating pH value, adsorbing eluting, vacuum concentrating, drying, pulverizing and shaping.

Description

technical field [0001] The invention relates to a compound Chinese herbal medicine preparation, in particular to an anti-tumor compound Chinese herbal medicine preparation and its preparation method and application. Background technique [0002] The compound three-root prescription mainly includes Polygonum cuspidatum root, Tengli root and Salicymus root, which are derived from empirical prescriptions, and their proportions are equal proportions (Yu Rencun, Commonly Used Prescriptions for Tumors, Oncology of Traditional Chinese Medicine, 1997: 21). In the treatment of gastrointestinal tumors, it is suggested that it has a significant anti-tumor effect (Bao Suzhen, Sun Zaidian, etc., 120 cases of advanced colorectal cancer treated with traditional Chinese medicine compound Sangen decoction combined with chemotherapy, Liaoning Journal of Traditional Chinese Medicine, 1992 (7): 33-34), However, the active ingredients are not clear and have not been fur...

Claims

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Application Information

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IPC IPC(8): A61P35/00
Inventor 叶勇
Owner SOUTH CHINA UNIV OF TECH
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