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Blackberrylily rhizome antiviral injection, preparation and venous medicine feeding blackberrylily rhizome antiviral injection thereof

An injection and antiviral technology, applied in antiviral agents, drug delivery, pharmaceutical formulations, etc., can solve problems such as pain, inconvenience, congestion, and even muscle necrosis, avoiding degradation, inconvenience, and prolonged use. Effect of quality expiration date

Inactive Publication Date: 2005-10-12
诺氏制药(吉林)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] Since the existing route of administration of Shegan Antiviral Injection is intramuscular injection, it is inconvenient to use clinically, the administration site of the patient is painful, and it is easy to cause adverse reactions such as congestion and even muscle necrosis.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Take 500g of Shegan, 400g of Honeysuckle, 300g of Peilan, 200g of Capillary, 150g of Bupleurum, 250g of Dandelion, 400g of Radix Isatidis, and 300g of Folium Folium, add purified water 3 times the weight of the medicinal material, and use steam distillation to collect the distillate as 1% of the medicinal material. / 5, the distilled liquid is redistilled, and the refined liquid is about 1 / 8 of the weight of the medicinal material, and it is used for later use; the distilled medicinal residue is added to purified water 5 times the weight of the medicinal material, and boiled and decocted twice, each time for 1 hour, Filter through filter paper, combine the two filtrates, concentrate the filtrate, add 0.06% of the weight of the concentrated solution to the clarifier B, heat to 70-90°C, let stand for 2 hours, then add 0.03% of the weight of the concentrated solution to clarify Agent A, after standing still for 4 hours, centrifuge, pour out the supernatant, and concentrate t...

Embodiment 2

[0050] Take 50g of Shegan, 900g of honeysuckle, 100g of Peilan, 300g of capillary, 150g of Bupleurum, 250g of dandelion, 100g of Radix Isatidis, and 200g of Folium Folium. / 6, the distilled liquid is redistilled, and the refined liquid is about 1 / 7 of the weight of the medicinal material, and it is used for later use; the distilled medicinal residue is added to purified water 6 times the weight of the medicinal material, and boiled and decocted twice, each time for 1 hour, Filter through filter paper, combine the two filtrates, concentrate the filtrate, add 0.04% of the weight of the concentrated solution to the clarifier B, heat to 70-90°C, let stand for 2 hours, then add 0.02% of the weight of the concentrated solution to clarify Agent A, after standing for 4 hours, centrifuge, pour out the supernatant, and concentrate to 3g of crude drug per ml; add ethanol under slow stirring, add ethanol to make the alcohol content 75%, refrigerate at 4-8°C For 48 hours, filter through fi...

Embodiment 3

[0053] Take 900g of Shegan, 100g of Honeysuckle, 100g of Peilan, 150g of Capillary, 300g of Bupleurum, 50g of Dandelion, 200g of Radix Isatidis, 150g of Folium Folium, add purified water 6 times the weight of the medicinal material, and collect the distillate by steam distillation to be 1% of the medicinal material. / 4, the distillate is redistilled, and the refined liquid is about 1 / 6 of the weight of the medicinal material, which is set aside; the distilled medicinal residue is boiled and decocted twice with purified water 4 times the weight of the medicinal material, each time for 1.5 hours, Filter through filter paper, combine the two filtrates, concentrate the filtrate, add 0.06% of the weight of the concentrated solution to the clarifier B, heat to 70-90°C, let stand for 2 hours, then add 0.03% of the weight of the concentrated solution to clarify Agent A, after standing for 4 hours, centrifuge, pour out the supernatant, and concentrate to 3.3g of crude drug per ml; add e...

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PUM

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Abstract

The invention relates to Blackberrylily rhizome antiviral injection, preparation and venous medicine feeding blackberrylily rhizome antiviral injection thereof. The original medicine comprises 1-1000 portion of belamcanda rhizome by weight, 1-1000 portion of honeysuckle by weight, 1-1000 portion of Eupatorium by weight, 1-1000 portion of capilary artemisia by weight, 1-1000 portion of radix bupleuri by weight, 1-1000 portion of dandelion by weight, 1-1000 portion of isatis root by weight, 1-1000 portion of dyers woad leaf by weight. The medicine is obtained by following steps: distilling by vapor, boiling, adding adding clarifier, alcohol-settling, water-settling, centrifugation, hyperfiltration to get active component of the Blackberrylily rhizome antiviral injection, and then subpackaging, disinfecting to get finished preparation, in which the chlorogenic acid (C16H18O9) is not less than 0.5 mg / ml. The injection has the function of antivirus and killing bacteria and relieving inflammation and treating epidemic hemorrhagic fever early disease. The invention avoids the medicine liquid thickness, deposition and color changing, stabilizes the preparation, prolongs the product effective date. The injection can be applied through vein so as to prevent the adverse effects such as pain in the administration location, blood stasis and even muscle necrosis.

Description

field of invention [0001] The invention relates to a Shegan antiviral injection, its preparation method and intravenous administration of the Shegan antiviral injection, belonging to the field of traditional Chinese medicine preparations. Background technique [0002] Shegan, also known as black fan, black pu, ghost fan, wild day lily, flat bamboo, golden butterfly, etc., is the dried rhizome of the perennial herbaceous plant Shegan; bitter and cold in nature; the main ingredients are Sheganding, irisin, iris flavonoids , Iris flavonoid glycosides, Sheganol, etc. Shegan water decoction has the effect of resisting pathogenic microorganisms. [0003] Honeysuckle, alias honeysuckle flower, silver flower, egret flower, Su flower, golden flower, double flower, two flower, two treasure flower, is a perennial semi-perennial green winding woody plant Lonicera, red gland honeysuckle, mountain silver flower Or the dry flower buds of Lonicera trichomes or the flowers with early openi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61P31/12
Inventor 郭智华
Owner 诺氏制药(吉林)有限公司
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