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Medicinal composition for treating arteriosclerosis

A kind of arteriosclerosis and composition technology, applied in the field of pharmaceutical compositions

Inactive Publication Date: 2005-10-12
SANKYO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, it is not known that combining ADP receptor antagonists and ACAT inhibitors is more effective in preventing or treating arteriosclerosis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] Experiments were carried out with male New Zealand white rabbits (body weight 1.0-1.5 kg), which were fed a cholesterol diet (0.5% cholesterol, 3% peanut oil and 3% coconut oil) for 10 consecutive weeks at the following feeding rates. 40g for the first 2 weeks, 50g for the next 4 weeks, and 60g for the last 4 weeks. After 2 weeks of cholesterol food feeding, nylon threads were aseptically inserted from the right femoral artery to the vicinity of the diaphragm, causing chronic endothelial injury of the abdominal aorta and right femoral artery. The nylon thread was secured at the insertion site for 8 weeks. After the operation of inserting the nylon thread, the rabbits were divided into groups, and the average values ​​of serum total cholesterol value, neutral fat value, platelet aggregation rate and body weight were approximately uniform in each group, and then ADP receptor antagonist and ACAT inhibitor were orally administered. single dose or combined administration of...

preparation example 1

[0100] (Formulation Example 1) Tablet

[0101] 2-Acetoxy-5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine (10.0 mg), N -(1-Octyl-5-carboxymethyl-4,6-dimethylindol-7-yl)-2,2-dimethylpropionamide (30.0 mg), lactose (408.0 mg), Corn starch (50.0 mg) and magnesium stearate (2.0 mg) were mixed and compressed by a tablet machine to make tablets of 500 mg each. If desired, the tablet may be coated (preferably sugar-coated).

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PUM

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Abstract

A medicinal composition, wherein an ADP receptor antagonist and an ACAT inhibitor are administered either simultaneously or separately at a defined interval as a preventive or a remedy (in particular, a remedy) for arteriosclerosis or diseases derived from arteriosclerosis such as ischemic heart disease, ischemic brain disease and peripheral circulation failure in warm-blooded animals (in particular, humans).

Description

technical field [0001] The present invention relates to a pharmaceutical composition which inhibits adenosine-5'-diphosphate (hereinafter abbreviated as ADP) receptor antagonist and fatty acyl-CoA·cholesterol acyltransferase (hereinafter abbreviated as ACAT) The agents are administered simultaneously or separately to prevent or treat (especially treat) arteriosclerosis or diseases caused by arteriosclerosis (especially arteriosclerosis). Background technique [0002] The incidence of atherosclerosis is increasing with the Europeanization of the diet and the aging of the population. Atherosclerosis is a major cause of myocardial infarction, cerebral infarction, cerebral hemorrhage, peripheral circulatory disturbance, and the like, so it is desired to develop an effective preventive method and a therapeutic method. Risk factors for atherosclerosis include hyperlipidemia (especially hypercholesterolemia), hypertension, or abnormal glucose metabolism based on insulin resistance...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/145A61K31/167A61K31/17A61K31/255A61K31/404A61K31/405A61K31/4365A61K31/4439A61K31/661A61K31/663A61K45/06A61P9/00A61P9/10A61K45/00
CPCA61K31/663A61K45/06A61K31/145A61K31/4365A61K31/17A61K31/255A61K31/167A61K31/4439A61K31/405A61K31/661A61K31/404A61P9/00A61P9/10A61K2300/00
Inventor 浅井史敏稻叶寿守小川武利
Owner SANKYO CO LTD