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Compound radical lobelia dripping pill and its preparing method

The technology of lobelia and lobelia, applied in the field of compound lobelia dropping pills and preparation thereof, can solve the problems of low dissolution rate, unfavorable improvement of patients' ability to seek medical treatment, complicated production process, etc., and achieves accelerated dissolution and absorption, and improved bioavailability. , the effect of less allergic reaction

Active Publication Date: 2005-10-19
BEIJING JIUFA PHARMA
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  • Summary
  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

[0012] In addition, the oral preparations of most drugs, especially the oral preparations of traditional Chinese medicine, have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking, which affect the quality of the drug. Efficacy, also directly affects the therapeutic effect Conventional oral dosage forms, such as tablets, capsules, etc.
In addition, due to the granulation process in the preparation process, large dust pollution will be generated, which will cause harm to the health of the staff to a certain extent, and will also cause certain pollution to the environment.
Furthermore, the production process of conventional oral preparations is complicated and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0035] Now with several groups of specific examples, the preparation method of compound Fangbianlian dripping pills of the present invention will be further described.

[0036] Group 1: Tests with a single matrix

[0037] 1. According to [Preparation Method] 1, pre-prepared extract dry powder containing 3 pure Chinese medicine active pharmaceutical ingredients such as Lobelia, Scutellaria barbata, and Hedyotis diffusa;

[0038] 2. Substrate: polyethylene glycol (1000~20000) , polyoxyl 40 stearate, beta cyclodextrin, poloxamer, sodium carboxymethyl starch, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac;

[0039] 3. Proportion: take g or kg as the unit, by weight, drug extract: matrix = 1:1~1:9;

[0040] 4. Then prepare according to the process of [Preparation Method] 4-7, that is, compound Lobelia dripping pills of various specifications can be prepared.

[0041] [test results]

[0042] Test 1: In order to observe the difference in quality o...

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PUM

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Abstract

The compound radical lobelia dripping pill is a kind of oral medicine composition preparation for treating multiple furuncle, tonsillitis, mastitis, etc. It has high bioavailability, fast medicine release, fast acting, high effective component content, low cost and less toxic side effect, and the production process has no pollution. The compound radical lobelia dripping pill is prepared with radical lobelia, sun plant and oldenlandia as Chinese medicinal materials and matrix carrier.

Description

technical field [0001] The present invention relates to a kind of medicinal composition that has heat-clearing and toxic substances removing, reducing swelling and relieving pain, and is used for the treatment of diseases such as multiple boils, tonsillitis, mastitis, etc. An oral preparation of a pharmaceutical composition prepared from three traditional Chinese medicines as raw materials. Background technique [0002] According to the formula and extraction process given in the Ministry of Drugs Standard WS-10609 (ZD-0609)-2002, the compound lobelia injection is a kind of compound lobelia injection, which has the functions of clearing heat, detoxifying, reducing swelling and relieving pain, and is used for multiple boils. The traditional Chinese medicine injection preparations for the treatment of swelling, tonsillitis, mastitis and other diseases have been clinically verified for many years, with stable quality and definite curative effect. They are commonly used pharmace...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61P11/04A61P15/14A61P17/02
Inventor 曲韵智
Owner BEIJING JIUFA PHARMA
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