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Motherwort extract dispersed tablet and preparation method of motherwort extract

A technology of motherwort extract and dispersible tablets, which can be applied to medical preparations containing active ingredients, drug combinations, and pharmaceutical formulas, and can solve problems such as slow onset of action

Inactive Publication Date: 2005-11-23
ANHUI AN TECH MEDICAL & BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The shortcomings of the above dosage forms are mainly made by water extraction or water extraction and alcohol precipitation. Compared with modern research results (such as low alkaloid content in water extraction), there is some irrationality. The old dosage forms have a slow onset of action.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0081] Motherwort Extract 20%

[0082] Pregelatinized Starch 30%

[0083] Microcrystalline Cellulose 42%

[0084] Crospovidone 4.5%

[0085] Stevioside 3.0%

[0086] 2% PVP (50% ethanol solution) appropriate amount

[0087] Magnesium Stearate 0.5%

[0088] Preparation of motherwort extract

[0089] Take motherwort that meets the requirements of the current version of the Chinese Pharmacopoeia, chop it up, add 1-3% hydrochloric acid or 1-2% sulfuric acid ethanol to soak the liquid according to the percolation method, release the ethanol liquid, and recover the ethanol under reduced pressure until the relative density of the concentrated liquid is 1.20 ~1.25 (50°C), add neutral water until the crude drug:volume ratio is 1:1, heat to dissolve, filter, concentrate the solution until the crude drug:volume ratio is 5:1, set aside; add 8 to 10 times the amount of water to extract the dregs 2 times, 2 hours each time, combi...

Embodiment 2

[0094] Motherwort Extract 20%

[0095] Lactose 15%

[0096] Starch 14%

[0097] Microcrystalline Cellulose 40%

[0098] Stevioside 1.0%

[0099] Low Substituted Hydroxypropyl Cellulose 9.5%

[0100] 2% PVP (50% ethanol solution) appropriate amount

[0101] Magnesium Stearate 0.5%

[0102] Take motherwort extract, lactose, starch, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, and stevioside, mix well, use 2% PVP (50% ethanol solution) to make soft materials, granulate, dry, and add whole grains Magnesium stearate is mixed evenly, and compressed into tablets to obtain Leonurus dispersible tablets.

[0103] The obtained dispersible tablets have the following properties:

[0104] Uniformity of dispersion: It complies with the provisions of the Pharmacopoeia, that is, in water at 20°C±1°C, it should be completely disintegrated within three minutes and pass through the No. 2 sieve.

Embodiment 3

[0106] Motherwort Extract 25%

[0107] Lactose 12%

[0108] Pregelatinized Starch 46%

[0109] Crospovidone 15%

[0110] 2% PVP (50% ethanol solution) appropriate amount

[0111] Stevioside 1.5%

[0112] Magnesium Stearate 0.5%

[0113] Take motherwort extract, lactose, pregelatinized starch, crospovidone, and stevioside and mix well, use 2% PVP (50% ethanol solution) to make soft materials, granulate, dry, and add magnesium stearate to the whole grain Mix evenly and compress into tablets, namely Motherwort Dispersible Tablets.

[0114] The obtained dispersible tablets have the following characteristics:

[0115] Uniformity of dispersion: It complies with the provisions of the Pharmacopoeia, that is, in water at 20°C±1°C, it should be completely disintegrated within three minutes and pass through the No. 2 sieve.

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Abstract

The invention discloses a motherwort extract dispersed tablet and preparation method of motherwort extract, wherein the dispersible tablet comprises 10-50 wt% leonurus heterophyllus sweet extract and 50-90 wt% auxiliary materials, the auxiliary materials include disintegrating agent, bulking agent, lubricating agent and flavoring agent.

Description

Technical field: [0001] The invention relates to a traditional Chinese medicine motherwort extract and a dispersible tablet thereof. Background technique [0002] Motherwort is the dry aerial part of Motherwort of Lamiaceae. It is a commonly used traditional Chinese medicine recorded in the previous editions of the Chinese Pharmacopoeia. The active ingredients are mainly total alkaloids and flavonoids. It has the effect of promoting blood circulation and regulating menstruation, promoting diuresis and reducing swelling. Modern pharmacological studies have proved that it has the effects of regulating menstruation and hemostasis, protecting myocardial ischemia-reperfusion injury, anti-platelet aggregation, and reducing blood viscosity; Myocardial ischemia, etc. At present, motherwort is used as raw material for preparations of motherwort capsules, motherwort oral liquid, and motherwort granules. The disadvantages of the above dosage forms are mainly that they are all made b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
Inventor 余世春
Owner ANHUI AN TECH MEDICAL & BIOLOGICAL TECH
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