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Chinese medicine injection agent for treating cardio-cerebrovascular diseases and its preparing method

A technology for cardiovascular and cerebrovascular diseases and injections, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, and unknown raw materials, etc., can solve problems such as affecting clinical treatment effects and difficult quality control, and is conducive to storage and improving controllability. Effects of Sex and Stability

Inactive Publication Date: 2005-12-21
王衡新
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Injections are easily affected by many factors such as production, storage, and transportation, and the quality is difficult to control, which affects the clinical treatment effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Take an appropriate amount of Erigeron breviscapitalis, add water and decoct twice, 2 hours each time, combine the decoction, filter, concentrate under reduced pressure to a relative density of about 1.35 (70°C), add ethanol until the alcohol content reaches 80%, refrigerate for 48 hours, filtered, the filtrate recovered ethanol under reduced pressure and concentrated to a relative density of 1.38 (70°C), extracted by shaking with ethyl acetate, concentrated the extract under reduced pressure, and measured the total flavonoid content to obtain the extract of Erigeron breviscapine, which was taken Add an appropriate amount of Erigeron breviscapitalis extract (containing 4.5g of total flavonoids) to dissolve in water for injection, adjust the pH value with 5mol / L sodium hydroxide solution, add water for injection, cool and let stand, make a total of 1000ml, add activated carbon, stir well, Boil for 10 minutes, cool and filter, add an appropriate amount of water for injecti...

Embodiment 2

[0019] Take an appropriate amount of Erigeron breviscapitalis, add water and decoct twice, 2 hours each time, combine the decoction, filter, concentrate under reduced pressure to a relative density of about 1.35 (70°C), add ethanol until the alcohol content reaches 80%, refrigerate for 48 hours, filtered, the filtrate recovered ethanol under reduced pressure and concentrated to a relative density of 1.38 (70°C), extracted by shaking with ethyl acetate, concentrated the extract under reduced pressure, and measured the total flavonoid content to obtain the extract of Erigeron breviscapine, which was taken Take an appropriate amount of Erigeron breviscapus extract (containing 4.5g of total flavonoids), add water for injection to dissolve, adjust the pH value with 5mol / L sodium hydroxide solution, add water for injection, cool and stand still, and make a total of 1000ml, add 0.1% sub- Sodium bisulfate or sodium pyrosulfite stabilizer or its mixture, 3% mannitol as a support agent, ...

Embodiment 3

[0021] Take an appropriate amount of Erigeron breviscapitalis, add water and decoct twice, 2 hours each time, combine the decoction, filter, concentrate under reduced pressure to a relative density of about 1.35 (70°C), add ethanol until the alcohol content reaches 80%, refrigerate for 48 hours, filtered, the filtrate recovered ethanol under reduced pressure and concentrated to a relative density of 1.38 (70°C), extracted by shaking with ethyl acetate, concentrated the extract under reduced pressure, and measured the total flavonoid content to obtain the extract of Erigeron breviscapine, which was taken Appropriate amount of Erigeron breviscapitalis extract (containing 4.5g of total flavonoids), add water for injection to dissolve, adjust pH value with 5mol / L sodium hydroxide solution, add water for injection, cool and stand still, make a total of 1000ml, add 0.05% stabilized Add sodium bisulfite or vitamin C or their mixture, or fill with nitrogen, then add 3% dextran as a sup...

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Abstract

The present invention discloses a Chinese medicine injection for curing angiocardiopathy and cerebrovascular disease and its preparation method. It is a fleabane powder injection or freeze-dried powder injection whose main component is fleabane extract. Besides, said invention also provides the concrete steps of its preparation method. Said preparation method can raise controllability and stability of product quality.

Description

Technical field: [0001] The invention relates to a traditional Chinese medicine injection and a preparation method thereof, in particular to breviscapine asarum powder injection or freeze-dried powder injection and a preparation method thereof. Background technique: [0002] Powder injection or freeze-dried powder injection is a pharmaceutical dosage form, and according to the relevant laws and regulations on drug management in my country, changing the dosage form is managed as a new drug research. This product is available as an injection solution, which has been included in the standards issued by the Ministry of Pharmaceuticals. [0003] The technical characteristics of the existing breviscapine injection for treating cardiovascular and cerebrovascular diseases are to decoct the breviscapine in the prescription twice with water, combine the decoction, concentrate, add ethanol, refrigerate, filter, and decompress the filtrate Recover ethanol and concentrate, extract with ...

Claims

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Application Information

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Inventor 王衡新
Owner 王衡新
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