Chinese medicine injection agent for treating cardio-cerebrovascular diseases and its preparing method

A technology for cardiovascular and cerebrovascular diseases and injections, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, and unknown raw materials, etc., can solve problems such as affecting clinical treatment effects and difficult quality control, and is conducive to storage and improving controllability. Effects of Sex and Stability

Inactive Publication Date: 2005-12-21
王衡新
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Injections are easily affected by many factors such as production, storage, and transp

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0016] Example one:

[0017] Take appropriate amount of Erigeron breviscapus, add water and decoct twice for 2 hours each time, combine the decoction, filter, reduce pressure and concentrate to a relative density of about 1.35 (70℃), add ethanol to 80% alcohol content, refrigerate 48 After hours, filtered, the filtrate was decompressed to recover ethanol and concentrated to a relative density of 1.38 (70°C), extracted with ethyl acetate by shaking, the extract was concentrated under reduced pressure, and the total flavonoid content was determined to obtain Erigeron breviscapus extract. An appropriate amount of breviscapine extract (containing 4.5g of total flavonoids) is dissolved in water for injection, the pH value is adjusted with 5mol / L sodium hydroxide solution, water for injection is added, and the mixture is left to cool to make a total of 1000ml. Add activated carbon and stir evenly. Boil for 10 minutes, cool and filter, add appropriate amount of water for injection, to ob...

Example Embodiment

[0018] Embodiment two:

[0019] Take appropriate amount of Erigeron breviscapus, add water and decoct twice for 2 hours each time, combine the decoction, filter, reduce pressure and concentrate to a relative density of about 1.35 (70℃), add ethanol to 80% alcohol content, refrigerate 48 After hours, filtered, the filtrate was decompressed to recover ethanol and concentrated to a relative density of 1.38 (70°C), extracted with ethyl acetate by shaking, the extract was concentrated under reduced pressure, and the total flavonoid content was determined to obtain Erigeron breviscapus extract. An appropriate amount of breviscapine extract (containing 4.5g of total flavonoids), add water for injection to dissolve, adjust the pH value with 5mol / L sodium hydroxide solution, add water for injection, cool and stand, make a total of 1000ml, add 0.1% of sub Sodium bisulfate or sodium metabisulfite stabilizer or its mixture, 3% mannitol as a support agent, stir to completely dissolve it, then ...

Example Embodiment

[0020] Embodiment three:

[0021] Take appropriate amount of Erigeron breviscapus, add water and decoct twice for 2 hours each time, combine the decoction, filter, reduce pressure and concentrate to a relative density of about 1.35 (70℃), add ethanol to 80% alcohol content, refrigerate 48 After hours, filtered, the filtrate was decompressed to recover ethanol and concentrated to a relative density of 1.38 (70°C), extracted with ethyl acetate by shaking, the extract was concentrated under reduced pressure, and the total flavonoid content was determined to obtain Erigeron breviscapus extract. An appropriate amount of breviscapine extract (containing 4.5g of total flavonoids), add water for injection to dissolve, adjust the pH value with 5mol / L sodium hydroxide solution, add water for injection, cool and stand, make a total of 1000ml, add 0.05% for stability Sodium bisulfite or vitamin C or its mixture, or nitrogen, add 3% dextran as a support agent, stir to completely dissolve it, a...

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PUM

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Abstract

The present invention discloses a Chinese medicine injection for curing angiocardiopathy and cerebrovascular disease and its preparation method. It is a fleabane powder injection or freeze-dried powder injection whose main component is fleabane extract. Besides, said invention also provides the concrete steps of its preparation method. Said preparation method can raise controllability and stability of product quality.

Description

Technical field: [0001] The invention relates to a traditional Chinese medicine injection and a preparation method thereof, in particular to breviscapine asarum powder injection or freeze-dried powder injection and a preparation method thereof. Background technique: [0002] Powder injection or freeze-dried powder injection is a pharmaceutical dosage form, and according to the relevant laws and regulations on drug management in my country, changing the dosage form is managed as a new drug research. This product is available as an injection solution, which has been included in the standards issued by the Ministry of Pharmaceuticals. [0003] The technical characteristics of the existing breviscapine injection for treating cardiovascular and cerebrovascular diseases are to decoct the breviscapine in the prescription twice with water, combine the decoction, concentrate, add ethanol, refrigerate, filter, and decompress the filtrate Recover ethanol and concentrate, extract with ...

Claims

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Application Information

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Inventor 王衡新
Owner 王衡新
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