The invention relates to the technical field of processing of auxiliary devices of liquid crystal displays, and in particular to a substrate edge polishing device for liquid crystal display module production. The substrate edge polishing device improves the fixing effect on glass substrates, prevents the glass substrates from shifting in the edge polishing process and improves the working efficiency. The substrate edge polishing device comprises a workbench, a left supporting plate, a right supporting plate, a top plate, a placing table, an air cylinder, a fixing plate, a stepping motor, a mounting plate, a substrate fixing device, a piston rod and a rotating shaft, wherein the substrate fixing device comprises a front transverse plate, a rear transverse plate, longitudinal threaded tubes,front threaded rods, rear threaded rods, transverse threaded tubes, left threaded rods, right threaded rods, front connecting blocks, rear connecting blocks, mounting blocks, a left ball bearing, a right ball bearing, a front ball bearing, a rear ball bearing and a powerful sucker; and the substrate edge polishing device further comprises a left electric cylinder, a right electric cylinder, a left connecting plate, a right connecting plate, a reciprocating motor, a screw rod, a slider, an edge polishing motor, a left telescopic rod, a right telescopic rod, a rear supporting plate, a front supporting plate, a lower ball bearing and an edge polishing wheel.