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Method for preparing visible polysaccharide membrane used as carrier of medicine for treating eye surface diseases

A manufacturing method and drug-carrying technology, applied in sensory diseases, sheet delivery, drug combination and other directions, can solve the problems of increasing patients' compliance with doctor's orders, aggravating patients' eye diseases, affecting treatment effects, etc. Long-lasting, antibacterial enhancement effect

Inactive Publication Date: 2006-04-12
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the frequent use of medication, it is difficult for patients to follow the doctor's advice, which often affects the therapeutic effect or aggravates some patients' eye diseases.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] (1) preparation of colloidal aqueous solution: take by weighing respectively molecular weight and be that the degree of deacetylation of 700KD is 80% chitosan 0.7g (the degree of deacetylation of chitosan is the sugar residue number that removes acetyl group in chitosan molecule Accounting for the percentage of the total sugar residue number in the chitosan molecule, the same below) and the carboxymethylation degree of 500KD as the carboxymethyl chitin 0.3g (the carboxymethylation of carboxymethyl chitin) of 92% Degree is the carboxymethyl number of sugar residues in the carboxymethyl chitin molecule accounts for the percentage of the total sugar residues in the carboxymethyl chitin molecule, the same below), put in a clean glass container, add 48.5g water , add 0.5g of glacial acetic acid to dissolve under stirring, and place it at 4-8°C until all the polysaccharides are dissolved into a transparent and clear colloidal solution. The weight ratio of chitosan and carboxy...

Embodiment 2

[0012] (1) Preparation of colloidal solution: take by weighing 0.9 g of chitosan whose deacetylation degree is 90% with a molecular weight of 500KD, place in a clean glass container, add 28.8 g of water, add 0.3 g of glacial acetic acid under stirring, and make chitosan The sugar is all dissolved. Take another 0.1g of hyaluronic acid with a molecular weight of 400KD, put it in another clean glass container, add 19.9g of water and stir to dissolve it into a colloid, and slowly add the chitosan glue into the hyaluronic acid glue under stirring conditions Mix evenly, remove air bubbles under vacuum, and place at 4-10°C. The weight ratio of chitosan and hyaluronic acid can be 1:0.1-1.0, and the total weight percentage in the glue solution can be 0.5%-5%.

[0013] (2) The preparation of the curvature diaphragm is the same as that in (2) of Example 1.

[0014] (3) Post-treatment and processing of the curvature membrane: Add 1ml of 0.1-2.0mol / L NaOH solution into the mold that has ...

Embodiment 3

[0016] (1) Preparation of colloidal solution: take by weighing 0.9g of chitosan with a molecular weight of 300KD and a deacetylation degree of 94%, place it in a clean glass container, add 28.8g of water, add 0.3g of glacial acetic acid under stirring, and make the shell All glycans are dissolved. Another get molecular weight is that the hydroxyethylation degree of 500KD is the hydroxyethyl chitosan 0.5g of 85% (the hydroxyethylation degree of hydroxyethyl chitosan is the sugar residue in the hydroxyethyl chitosan molecule). The number of hydroxyethyl groups accounts for the percentage of total sugar residues in hydroxyethyl chitosan molecules, the same below), in another clean glass container, add 20g of distilled water, stir until completely dissolved, and stir the chitosan glue Next, add hydroxyethyl chitosan glue, mix well, and store at 4-10°C. The weight ratio of chitosan and hydroxyethyl chitosan used is 1:0.1-1.0, and the total weight percentage in the colloid solution...

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Abstract

A medicine carried polyose membrane for treating the superficial ophthalmopathy by sticking it on eye area is prepared through preparing the aqueous solution of colloid from chitosan and carboxymethyl chitin or carboxymethyl chitosan or hyaluronic acid or hydroxyethyl chitosan, applying it on the concave mould made of stainless steel, centrifugal rotating while heating by electric light source or hot air to obtain dry membrane, neutralizing reaction, cross-linking reaction, sterilizing and immersing it in the antibiotic solution.

Description

technical field [0001] The invention relates to a method for manufacturing a drug-loaded visible curvature membrane for treating ocular surface diseases by using biological polysaccharides. Background technique [0002] Ocular surface disease is a common disease, including corneal ulcers caused by pathogenic bacteria infection, ocular surface trauma caused by ophthalmic surgery or mechanical force, ocular surface burns caused by chemical substances such as acid and alkali, ocular surface burns caused by heat source factors Injuries and other ocular surface diseases, etc., are currently treated with eye drops or ointment, in order to achieve sterilization and antibacterial of the wound, or prevent infection of the injured wound, and promote wound healing. However, due to the short retention time of the drug in the eyes, in order to maintain the efficacy of the drug, it is often required to instill the drug solution every 0.5 to 1 hour in clinical practice. Due to the frequen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36A61K9/70A61K31/5383A61P27/02
Inventor 刘万顺韩宝芹杨朝忠陈列欢位晓娟赵金铸
Owner OCEAN UNIV OF CHINA
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