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Application of plant extract for preparing medicine to cure bone absorption increment diseases and composition thereof

A technology of extracts and compositions, applied in the field of nutritional or pharmaceutical compositions, can solve problems such as bone loss, imbalance, etc.

Inactive Publication Date: 2006-06-07
UNIVERSITY OF BERN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, with age, there is an imbalance in the development of this remodeling process, resulting in bone loss

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] The following is an example of a suitable supplement composition of the present invention in powder form.

[0086] Supplement in powder form (1 serving)

[0087] Content 65.0g

[0088] Extract / concentrate of the present invention 1) 14.5g

[0089] Includes carbohydrates, protein, and fiber

[0090] Protein 20.0g

[0091] Includes - Calcium Casein Protein 8.7g

[0092] -Skim milk powder 11.0g

[0093] Fat 2.8g

[0094] Include - omega-6 polyunsaturated acids 1.3g

[0095] -omega-3 polyunsaturated acid 0.03g

[0096] Carbohydrates (including the extract of the present invention) 31.0g

[0097] Contains - Lactose 16.5g

[0098] - Maltodextrin 3.5g

[0099] Fiber (soluble) 5.0g

[0100] Other ingredients 3.0g

[0101] Contains - Na 230mg

[0102] -K 500mg

[0103] -Ca 600mg

[0104] -Mg 90mg

[0105] -P 430mg

[0106] -Cl 350mg

[0107] -Zn 150mg

[0108] - Retinol (Vitamin A) 0.3mg

[0109] - Ergocalciferol (Vitamin ...

Embodiment 2

[0129] Example 2: Effect of aqueous extracts of cauliflower, dog-parsley and onion on bone resorption

[0130] The effect of the plant or vegetable extracts and concentrates of the present invention on bone resorption is based on R.C. Mühlbauer and H. Fleisch in "American Journal of Physiology" 259 , the method described in R679-R689 (1990). As described in the reference mentioned above, using the [ 3 H]-tetracycline pre-labeled in the urine of Wistar rats 3 H excretion to monitor bone resorption. The rats were then housed in individual metabolic cages and treated with 1.0 g Ca, 0.7 g P, and 80 IU vitamin D 3 Standard experimental chow (Kliba 331, Klingentalmühle, Kaiseraugst, Switzerland) was fed per 100 g of food for 10 days. After this acclimatization period, all rats were given a diet containing 1.0 g Ca, 1.2 g P, and 80 IU vitamin D 3 / 100g dry weight of the diet. This was achieved by adding appropriate amounts of calcium gluconate in powder form and neutral phospha...

Embodiment 3

[0133] Example 3: The effect of bear onion concentrate on bone resorption

[0134] The same method as described in Example 2 was used, except that the treatment lasted only 6 days, and the test group (n=5) was given pure food also containing 1 g of bear's onion concentrate (obtained by drying and grinding fresh bear's onion). As a result, it was found that bear onion inhibited the bone resorption of male rats by 13.5% (p<0.05).

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PUM

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Abstract

The present invention relates to nutritional or pharmaceutical compositions containing extracts or concentrates of plants of the genus Brassica. The compositions of the invention are useful in the treatment or prevention of diseases or conditions characterized by increased bone resorption, such as Paget's disease, tumor-induced bone disease, or osteoporosis in particular.

Description

[0001] The present invention is a divisional case of a Chinese patent application with the application number 0210581.3, the filing date being May 4, 1998, and the title of the invention being "Plant extracts for the preparation of medicines for treating bone resorption diseases and their compositions" Application. technical field [0002] The present invention relates to nutritional or pharmaceutical compositions comprising certain plant extracts or concentrates, and their use as bone resorption inhibitors. Background technique [0003] The most common metabolic bone disease is osteoporosis. Osteoporosis can generally be defined as a decrease in the amount of bone mass caused by either reduced bone formation or accelerated bone resorption, which in either case results in a reduced amount of bone tissue. During the resorption process, osteoclasts (bone resorbing cells) cause depressions in parts of the bone. After resorption, osteoblasts (bone-forming cells) emerge to fill...

Claims

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Application Information

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IPC IPC(8): A61K36/48C12N5/04A01NA23L1/28A23L1/30A23L33/00A61KA61K9/02A61K9/14A61K9/20A61K9/28A61K9/48A61K31/198A61K31/201A61K31/225A61K31/59A61K31/593A61K31/70A61K33/06A61K35/20A61K36/00A61K36/18A61K36/23A61K36/31A61K36/896A61K36/8962A61K38/00A61P3/02A61P19/08A61P19/10
CPCA23V2002/00A61K31/59A61K33/06A61K36/23A61K36/31A61K36/8962A23L33/105A61P19/00A61P19/08A61P19/10A61P3/02A61P35/00A61K2300/00A23V2200/306A23V2250/21A23V2250/1578A23V2250/71A23V2250/1882
Inventor 罗曼·康拉德·米尔鲍尔
Owner UNIVERSITY OF BERN