Compound formulation containing cobamamide and mecobalamin, and its preparation method

Abstract

The invention belongs to the field of pharmaceutical preparation, in particular a compound preparation of cobamamide and mecobalamin and its preparing process, wherein each dosage unit of the medicinal preparation comprises cobamamide 0.05-5.0mg, mecobalamin 0.05-5.0mg.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and specifically relates to a compound pharmaceutical preparation of adenosylcobalamin and methylcobalamin, including oral solid preparations, injections, freeze-dried preparations for injections and preparation methods thereof. Background technique [0002] Adenosylcobalamin, English name: Cobamamide, chemical name: 5,6-dimethylimidazolyl-5`-deoxyadenosylcobalamin, is cyanocobalamin-type vitamin B 12 analogue of vitamin B 12 Metabolites in the body are vitamin B 12 One of the two active coenzyme forms in the body, it is a substance necessary for cell growth and proliferation and maintaining the integrity of nerve myelin sheath, compared with vitamin B 12 It has higher biological activity and bioavailability, can be directly absorbed and utilized by the human body, has strong activity, strong affinity with tissue cells, and slow excretion; it is an important coenzyme for synthesizing ...

AI Technical Summary

Problems solved by technology

[0004] Adenosylcobalamin and methylcobalamin are B vitamins 12 One of the two active coenzyme forms in the body, there are currently clinical preparations with a single adenosylcobalamin component and a single methylcobalamin component, such as adenosylcobalamin tablets, adenosylcobalamin for injection, and methylcobalamin Tablets, methylcobalamin capsules, methylcobalamin injection, methylcobalamin for injection and other preparations, but the combination of adenosylcobalamin and methylcobalamin to make pharmaceutical preparations suitable for taking has not been reported