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Solid phase micro-extraction device based on nanometer fiber

A technology of nanofibers and extractors, applied in solvent extraction, chemical instruments and methods, separation methods, etc., can solve problems such as limited application range, long processing time, and low enrichment efficiency, and achieve wide application range and simple and easy operation Line, the effect of large extraction capacity

Active Publication Date: 2006-07-26
SOUTHEAST UNIV
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Problems solved by technology

[0003] Technical problem: the purpose of the present invention is to provide a nanofiber-based solid-phase microextractor, which can overcome the single adsorbent, low enrichment efficiency, long processing time, limited application range, and still need in the prior art. Disadvantages such as a considerable volume of organic solvent, the need to dry the solvent step, and low cost

Method used

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  • Solid phase micro-extraction device based on nanometer fiber

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[0022] 1. Take a solid-phase microextraction column filled with 2 mg of 800-1000nm polystyrene fiber, draw 200 μl of 10 μg / ml trazodone (an antidepressant) aqueous solution (prepared in pH 7.4 phosphate buffer) with a syringe, and inject tube; then draw 200 μl pH7.4 phosphate buffer solution to inject and rinse the extraction tube; draw 50 μl methanol to inject and elute through the extraction tube; inject the eluate into the high-performance liquid chromatography for detection, and calculate the extraction recovery rate. Results The extraction recovery rate reached 99%.

[0023] 2. Conduct the experiment with the plasma sample that is recognized as the most complicated pretreatment, prepare 10 μg / ml trazodone plasma spiked sample, add the same amount of pH12 phosphate buffer to mix, inject a total of 200 μl into the extraction tube, and then use pH12 phosphate buffer 200 μl of solution was injected to rinse the extraction tube, and 50 μl of methanol was injected into the elue...

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Abstract

The invention relates the device which utilizes solid adsorbent to enrich, extract, and pretreat samples on the base of nanometer fabric solid phase extractor. The device comprises 1-injector, 2-conical extraction pipe, and 3-nanometer fabric filtering medium. The head of 1 and the back opening of 2 can be connected and separated. In the 2 there are 3, and the head of 2 there is an eyelet. On the head of 2 there is 4-sampling needle which can be connected and separated with the head of 2. The invention possesses the advantages of short handling time, little dissolvent and wide application area.

Description

technical field [0001] The invention relates to a device for enriching and extracting samples by using a solid adsorbent, performing sample pretreatment and sample introduction, especially a device for micro and trace samples applied to complicated medical and biological samples, environmental samples, poisons and pollutants The sampling device for rapid enrichment and pre-purification treatment. Background technique [0002] Modern analysis technology is developing towards fast, micro, trace, multi-component, and high selectivity. Various new types of precision instruments emerge in an endless stream, and higher and higher requirements are put forward for the sample pretreatment process. However, 60% or more of the analysis operation time is spent on sample pretreatment, and most of the experimental errors come from the sample pretreatment process. Solid phase extraction (SPE) is an effective means of separation and purification of trace or trace substances. Most of the cu...

Claims

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Application Information

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IPC IPC(8): B01D11/00
Inventor 顾忠泽康学军
Owner SOUTHEAST UNIV
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