Tissue engineering carrier material of polycaprolactone and its prepn process
A carrier material, polycaprolactone technology, applied in prosthesis, medical science, coating, etc., can solve problems such as no similar or similar patent reports, achieve controllable adjustment of degradation speed, simple equipment, and easy process control Effect
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Embodiment 1
[0020] The polymer PCL with a molecular weight of 10,000 and a melting point of 55°C is melt-spun at 100°C to obtain fibers with an average diameter of 10 μm, cut into equal lengths of 10.0mm, and filled into a mold with a specific shape. The rate is 85%, the temperature of the water bath is set to 50.0°C (the actual temperature is 49.5-50.5°C), the mold is sealed and placed in the water bath to keep the temperature for 1 hour, then taken out, cooled at room temperature, demoulded, and dried in vacuum for 24 hours. The tissue engineering carrier material with specific shape and good performance is obtained. The material has a pore size range of 50±40 μm measured by a scanning electron microscope, a porosity of 82% measured by a liquid displacement method, and a degree of pore penetration of more than 90%. The in vitro degradation cycle is long and the mechanical properties are excellent. The material can be used as a bone tissue engineering carrier material for the repair and ...
Embodiment 2
[0022] Polymer PCL with a molecular weight of 200,000 and a melting point of 65°C is melt-spun at 280°C to obtain fibers with an average diameter of 200 μm, cut to an equal length of 3.0 mm, and filled into a mold with a specific shape. The rate is 75%, the temperature of the water bath is set to 70.0°C (the control range is ±0.5°C), the mold is sealed and placed in the water bath to keep the temperature for 5 minutes, then taken out, cooled at room temperature, demoulded, and dried in vacuum for 24 hours to obtain Tissue engineering carrier material with specific shape and good performance. The measured pore size range of the material is 300±100 μm, the porosity is 68%, the in vitro degradation cycle is long, the mechanical properties are excellent, and the preliminary test proves that it has good biocompatibility. Due to the longer degradation cycle and controllable degradation rate, this material can also be used as a carrier material for tendon tissue engineering, and can ...
Embodiment 3
[0024]The polymer PCL with a molecular weight of 80,000 and a melting point of 58-60°C is melt-spun at 140°C to obtain fibers with an average diameter of 500 μm, which are cut into equal lengths of 1.0mm and filled into molds with specific shapes. Calculated based on a porosity of 60%, set the temperature of the water bath to 54.5°C (the control range is ±0.5°C), seal the mold and place it in the water bath for 20 minutes at a constant temperature, take it out, cool it at room temperature, demould it, and vacuum dry it for 24 hours. The tissue engineering carrier material with specific shape and good performance can be obtained. The measured pore size range of the material is 400±100 μm, the porosity is 55%, the in vitro degradation cycle is longer, the mechanical strength is higher, and the preliminary test proves that it has good biocompatibility. This material has superior mechanical properties and has the effect of inducing osteogenesis, and is more suitable for bone tissu...
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Abstract
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