Preparation method of nauclea officinalis powder medicine for injection

A kind of technology for injection and danmu, which is applied in the direction of pharmaceutical formula, medical preparations containing active ingredients, powder delivery, etc. It can solve the problems of easy precipitation, slow absorption, long disintegration time of danmu extract tablets, etc.

Inactive Publication Date: 2006-08-30
罗才良
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Danmu extract tablets take a long time to disintegrate, absorb slowly, and act slowly; Danmu injection is not as fast as intravenous injection, and cannot directly enter the blood like intravenous injection powder to kill germs at the fastest speed effect
At the same time, the Danmu injection for intramuscular injection, which is added with auxiliary materials such as co-solvent Tween 80, will have some adverse consequences on the human body, and the placement process is prone to precipitation, resulting in unstable quality
The patent application number is: No. 200410023036.8, the patent of "Banlan wood freeze-dried powder injection and its preparation method", which discloses a kind of preparation method of Dan wood freeze-dried powder injection, which is used when drying from liquid to solid It is freeze-drying. According to the conventional treatment of freeze-drying by those skilled in the art, the temperature of freeze-drying is generally between minus 30 and minus 40 degrees. Using this conventional technology for making powder injections, not only the drying is relatively slow, but also time-consuming It is troublesome, not conducive to improving productivity, and causing waste of energy

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0010] The method of making this medicine is to take gallwood and add water, put it under heat reflux and extract in the extraction tank until the extract is light yellow or almost colorless, the extract is filtered, concentrated to a clear liquid with a relative density of 1.18-1.19 (60°C thermal measurement) paste, add 4 times the amount of plaster powder, stir well, dry under reduced pressure at 70-80°C, crush through a 50-mesh sieve, add 85% ethanol to stir and extract three times, combine the ethanol liquid, refrigerate, stand for 24 hours, and take the supernatant solution, recover ethanol until there is no alcohol smell, add water for injection until the relative density is 1.02-1.03 (50 ℃ thermal measurement), let cool to room temperature, adjust the pH value to 2.0-3.0 with dilute hydrochloric acid, refrigerate, let stand for 24 hours, filter After filtering, adjust the pH value of the filtrate to 7.0-7.2 with 20% sodium hydroxide solution, refrigerate for 12 hours, fi...

Embodiment approach 2

[0012] The method of making this medicine is to take gallwood and add water, put it under heat reflux and extract in the extraction tank until the extract is light yellow or almost colorless, the extract is filtered, concentrated to a clear liquid with a relative density of 1.18-1.19 (60°C thermal measurement) paste, add 4 times the amount of plaster powder, stir well, dry under reduced pressure at 70-80°C, crush through a 50-mesh sieve, add 85% ethanol to stir and extract three times, combine the ethanol liquid, refrigerate, stand for 24 hours, and take the supernatant solution, recover ethanol until there is no alcohol smell, add water for injection until the relative density is 1.02-1.03 (50 ℃ thermal measurement), let cool to room temperature, adjust the pH value to 2.0-3.0 with dilute hydrochloric acid, refrigerate, let stand for 24 hours, filter After filtering, adjust the pH value of the filtrate to 7.0-7.2 with 20% sodium hydroxide solution, refrigerate for 12 hours, fi...

Embodiment approach 3

[0014] The method of making this medicine is to take the bile wood and add water, put it in a multi-functional extraction tank, add water to decoct three times, decoct for 2 hours for the first time, and 1.5 hours for the second and third times, combine the decoction, filter and concentrate To the clear paste with a relative density of 1.18-1.19 (60°C thermal measurement), add 4 times the amount of plaster powder, stir well, dry under reduced pressure at 70-80°C, crush through a 50-mesh sieve, add 85% ethanol and stir to extract three times. Combine the ethanol solution, refrigerate, let it stand for 24 hours, take the supernatant, recover the ethanol until there is no alcohol smell, add water for injection until the relative density is 1.02-1.03 (heat measurement at 50°C), let cool to room temperature, and adjust the pH with dilute hydrochloric acid value to 2.0-3.0, refrigerate, stand for 24 hours, filter, and adjust the pH value of the filtrate to 7.0-7.2 with 20% sodium hyd...

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PUM

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Abstract

A process for preparing the powder fatheadtree injection includes such steps as extracting in water, filtering, concentrating, adding gypsum powder, stirring, vacuum drying, pulverizing, extracting in alcohol 3 times, collecting liquid extract, cold storage, laying aside for 24 hr, taking supernatant, recovering alcohol, adding the water for injection, cooling, using diluted hydrochloric acid to regulate pH value, cold storage, laying aside for 24 hr, filtering, using the solution of sodium hydroxide to regulate pH value, cold storage, filtering, adding water, and vacuum drying.

Description

technical field [0001] The invention relates to a method for preparing the powder for injection of the extract of the eucalyptus extract obtained from the plant eucalyptus. Background technique [0002] Danmu has the function of clearing heat and detoxifying, and is used to treat acute tonsillitis, acute pharyngitis, acute conjunctivitis and upper respiratory tract infection. At present, there are only gallwood extract tablets and gallwood injection for intramuscular injection. Danmu extract tablets take a long time to disintegrate, absorb slowly, and act slowly; Danmu injection is not as fast as intravenous injection, and cannot directly enter the blood like intravenous injection powder to kill germs at the fastest speed effect. At the same time, the Danmu injection for intramuscular injection is added with auxiliary materials such as co-solvent Tween 80, which will have some adverse effects on the human body, and precipitation is prone to occur during the placement proce...

Claims

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Application Information

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IPC IPC(8): A61K36/74A61K9/14A61P11/04A61K129/00A61K135/00
Inventor 罗才良
Owner 罗才良
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