Compound saponin and flavone extract and its formulation and uses

A technology of extract, Fructus Fructus Fructus Fructus L., applied in the field of total extract of Fructus Fructus Fructus Fructus Fructus Fructus Fructus L.

Inactive Publication Date: 2006-10-04
赵晓昂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But now there is no Chinese patent medicine containing Zhi Zhizhi on the market

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1 The preparation of the total extract (1)

[0019] Grind gardenia, light tempeh, citrus aurantium, rhubarb medicinal materials or decoction pieces or processed decoction pieces (the ratio of the four is 4:8:1:3), pass through a 20-mesh sieve, put in an extraction tank and add ethanol for extraction, and concentrate the extract centrifuged, ethanol eluted and recovered after passing through the macroporous resin bed, and dried to obtain the extract;

[0020] Extraction conditions: ethanol concentration 15-80%, ethanol dosage 3-15 times the amount of medicinal materials, extraction time 1-3 hours, extraction times 1-4 times.

[0021] Concentration conditions: concentrated to a relative density of 0.9-1.3

[0022] Centrifugation conditions: centrifugal speed 3000-30000rpm, centrifugal time 15-45min

[0023] Elution conditions: the concentration of ethanol in the eluent is 10-90%, and the amount of eluent is 3-15 times that of the medicinal materials.

[0024] C...

Embodiment 2

[0026] Example 2 Preparation of total extract (2)

[0027] Grind gardenia, light tempeh, citrus aurantium, rhubarb medicinal materials or decoction pieces or processed decoction pieces (the ratio of the two is 1:2:1), pass through a 20-mesh sieve, and place in supercritical CO 2 Ethanol is added to the extractor for extraction;

[0028] Extraction conditions: pressure: 35Mpa, temperature: 45°C (±3°C);

[0029] Separation conditions: the first separation tank separation conditions: pressure: 10Mpa, temperature: about 45°C;

[0030] Conditions of the second separation tank: pressure: 5Mpa, temperature: 40°C (±3°C);

[0031] Collect the extract from the second extraction kettle, suction filter, centrifuge, and take the oil layer to obtain the total extract (3).

[0032] Experimental results: The sample yield is 3%, the content of geniposide is 14%, the content of isoflavone is 6%, and the content of synephrine is 5%.

Embodiment 3

[0033] Example 3 Preparation of Total Extract Tablets

[0034] Take the extract of Fructus Fructus Folium Fructus, mix with lactose, magnesium stearate, microcrystalline cellulose and other auxiliary materials, press to form a tablet, put it into a coating pan and add a coating liquid to coat. Near wind temperature: 40°C, atomization pressure: 3.5Kg, tablet bed temperature: 35°C, rotating speed: 4-10 minutes, tablet weight gain: 8%. The results showed that the tablet was smooth and delicate in appearance, completely covered, and disintegrated in compliance with regulations.

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PUM

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Abstract

Disclosed is a pharmaceutical preparation for tranquilizing, liver-preserving, allaying fever and relaxing bowels, which comprises 5-95% of iridoid glycosides, 1-90% of saponins, 1-90% of flavones, 1-90% volatile oils, and 1-90% of alkaloids.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, in particular, the invention relates to a compound total extract of Zhi Zhi Zhi Huang. Background technique [0002] Zhishi Zhiziqi Decoction is composed of gardenia, light tempeh, and citrus aurantium. Rhubarb can also be added to the prescription to increase its efficacy. It is one of the basic prescriptions of Zhiziqi Decoction in "Treatise on Febrile Diseases". Chi Tang added a taste of Citrus aurantium, on the basis of the prescription Gardenia bitter to purify fire, cold to clear heat and fragrant fermented pungent and sweet to dissipate and dissipate evil, added Citrus aurantium to dispel qi and eliminate accumulation, reduce phlegm and dissipate pimples, and then added Rhubarb has the effects of purging heat and dredging the intestines, cooling blood and detoxifying, expelling blood stasis and dredging the menstrual flow, so that its functions and indications have ch...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A61K9/00A61P25/20A61P25/22A61P25/24A61P25/00A61P29/00A61P31/16A61P31/10A61P31/12A61P11/00A61P17/00A61P17/02A61P17/10A61P17/14A61P1/04A61P1/16A61P1/10A61P1/12A61P15/12A61P19/10A61P3/06A61P9/12A61P9/10A61P35/00
CPCY02A50/30
Inventor 赵晓昂
Owner 赵晓昂
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