Effervescent tablet containing cefixime and its preparing method

A technology for cefixime and effervescent tablets, which is applied in the field of effervescent tablets containing cefixime and its preparation, can solve problems such as difficulty in uniform dispersion and difficulties, and achieve fast onset of action, high blood drug concentration, and good taste Effect

Inactive Publication Date: 2006-10-25
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Tablets, capsules, and dispersible tablets all have a certain volume and need to be swallowed by patients with water, which is difficult for children, the elderly, and patients who cannot swallow solid medicaments; while dry suspensions and granules are both in use. Need to add water to stir, otherwise it will be difficult to disperse evenly

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Cefixime 50g

[0032] Tartaric acid 150g

[0033] Sodium bicarbonate 100g

[0034] 170g cane sugar

[0035] 5% PVP aqueous solution 5 grams

[0036] PEG6000 10g

[0037] Aspartame 15g

[0038] 10g orange essence

[0039] Put 50 grams of cefixime, sodium bicarbonate and 70 grams of sucrose in a container and mix for 30 minutes, pass through a 20-mesh sieve while adding 5% PVP aqueous solution, and dry at 40 degrees for 45 minutes; in addition, put tartaric acid and 100 grams of sucrose in the container Mix in medium for 30 minutes, pass 20 mesh sieve while adding 5% PVP aqueous solution, and dry at 50 degrees for 40 minutes. The two-part granules, aspartame, orange flavor and PEG 6000 were mixed for 10 minutes, transferred to a tablet press equipped with 11 mm diameter shallow concave punches, and compressed into 1000 tablets.

[0040] Get 1 cefixime effervescent tablet prepared by the above-mentioned embodiment 1, put it in a 250ml beaker, which contains 200ml wa...

Embodiment 2

[0042] Cefixime 100g

[0043] Tartaric acid 130g

[0044] Sodium bicarbonate 100g

[0045] 170g cane sugar

[0046] PEG6000 5g

[0047] Acesulfame Potassium 15g

[0048] 10g orange essence

[0049] Put cefixime, tartaric acid, sodium bicarbonate, sucrose, orange essence, and aspartame in a container and mix for 30 minutes, transfer to a dry granulator for granulation, add PEG6000 and mix for 10 minutes, and then transfer to a container with diameter 11mm shallow concave punching tablet press, pressed into 1000 pieces.

[0050] Get 1 piece of cefixime effervescent tablet prepared by the above-mentioned embodiment 2, put it in a 250ml beaker, which contains 200ml water, and the water temperature is 24 degrees. It is found that many bubbles are released, and the effervescent tablet effervescently collapses within 2 minutes. solution completely. When the gas around the tablet or fragments stops escaping, the tablet is evenly dispersed in the water and no aggregated particle...

Embodiment 3

[0052] Cefixime 50g

[0053] Tartaric acid 100g

[0054] Potassium Bitartrate 40g

[0055] Sodium bicarbonate 100g

[0056] Sodium Carbonate 20g

[0057] Mannitol 200g

[0058] Peppermint essence 6 grams

[0059] Aspartame 10g

[0060] 5% PVP ethanol solution 50g

[0061] Sodium Lauryl Sulfate 10g

[0062] Put cefixime, tartaric acid, potassium hydrogen tartrate, sodium bicarbonate, sodium carbonate, sucrose, and aspartame in a container and mix for 30 minutes, while adding 5% PVP ethanol solution, while passing through a 20-mesh sieve, dry at 40 degrees for 45 minute. The dry granules, mint essence and PEG6000 were mixed for 10 minutes, transferred to a tablet press equipped with a shallow concave punch with a diameter of 12 mm, and compressed into 1000 tablets.

[0063] Get 1 cefixime effervescent tablet prepared by the above-mentioned embodiment 3, put it in a 250ml beaker, which contains 200ml water, and the water temperature is 22 degrees, and it is found that ma...

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Abstract

The present invention relates to an effervescent tablet containing cefixime and its preparation method. It contains 25-400 mg of cefixime and pharmaceutically-acceptable acid-dbase pair. Besides, the pharmaceutically-acceptable filling agent, adhesive, disintegrating agent, lubricating agent, sweetener and corrective also can be added according to the requirements.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to an effervescent tablet containing cefixime and a preparation method thereof. Background technique [0002] Cefixime is the third-generation oral cephalosporin, clinically suitable for pharyngitis, tonsillitis, acute bronchitis and acute exacerbation of chronic bronchitis, otitis media, urinary tract infection, simple gonorrhea (cervicitis or urethritis) caused by sensitive bacteria ) and other treatments. [0003] According to the Physician's Desk Reference (PDR57) version of the United States, after oral administration of cefixime tablets and dry suspensions, the absolute bioavailability is 40% to 50%, and the time to peak blood concentration after oral administration is 2 to 6 hours. Cefixime solid preparations have low bioavailability and slow onset of action. [0004] Cefixime is currently in the form of tablets, capsules, dry suspensions, granules, and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/546A61K9/20A61K9/46A61P11/00A61P13/00A61P15/00A61P27/16A61P31/04
Inventor 张建军高缘
Owner CHINA PHARM UNIV
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