Effervescent tablet containing cefixime and its preparing method

A technology for cefixime and effervescent tablets, which is applied in the field of effervescent tablets containing cefixime and its preparation, can solve problems such as difficulty in uniform dispersion and difficulties, and achieve fast onset of action, high blood drug concentration, and good taste Effect
CN1850087AInactive Publication Date: 2006-10-25CHINA PHARM UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHINA PHARM UNIV
Publication Date
2006-10-25
Estimated Expiration
Not applicable · inactive patent
Patent Text Reader

Abstract

The present invention relates to an effervescent tablet containing cefixime and its preparation method. It contains 25-400 mg of cefixime and pharmaceutically-acceptable acid-dbase pair. Besides, the pharmaceutically-acceptable filling agent, adhesive, disintegrating agent, lubricating agent, sweetener and corrective also can be added according to the requirements.
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Description

technical field

[0001] The invention relates to the technical field of pharmaceutical preparations, in particular to an effervescent tablet containing cefixime and a preparation method thereof. Background technique

[0002] Cefixime is the third-generation oral cephalosporin, clinically suitable for pharyngitis, tonsillitis, acute bronchitis and acute exacerbation of chronic bronchitis, otitis media, urinary tract infection, simple gonorrhea (cervicitis or urethritis) caused by sensitive bacteria ) and other treatments.

[0003] According to the Physician's Desk Reference (PDR57) version of the United States, after oral administration of cefixime tablets and dry suspensions, the absolute bioavailability is 40% to 50%, and the time to peak blood concentration after oral administration is 2 to 6 hours. Cefixime solid preparations have low bioavailability and slow onset of action.

[0004] Cefixime is currently in the form of tablets, capsules, dry suspensions, granules, and ...

Claims

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