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Medicine composition for treating microcirculation dysfunction and its preparing method

A circulatory disorder and composition technology, applied in the field of pharmaceutical compositions for various diseases, can solve problems such as difficulty in obtaining satisfactory therapeutic effects and the like

Inactive Publication Date: 2006-11-08
SINOPHARM A THINK PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Since the treatment of microcirculation disorders, especially those caused by diabetes, is an extremely complicated process, it is difficult to achieve satisfactory therapeutic effects with a single drug

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Pass the raw and auxiliary materials through a 100-mesh sieve, take 5g of calcium dobesilate and 500g of pueraria flavonoids, add microcrystalline cellulose and sodium carboxymethyl starch and mix evenly, add 15% PVP to make a soft material, use 16-24 mesh Sieve and granulate, dry the wet granules at 50-80°C, sieve the granules with 16-24 mesh, add magnesium stearate and mix evenly, measure the content of the main drug in the granules, and then compress into tablets to make 2000 tablets.

[0040] Among them, the extraction method of Pueraria flavonoids is as follows: Take 10 kg of Pueraria root, add 6 times the amount of water to decoct three times, the first time is 1.0 hours, the second and third times are 0.5 hours, filter respectively, combine the filtrates, and concentrate to a relative density of 1.08 ~ 1.14 (55°C) clear paste, add 2.8 times of ethanol to the clear paste while stirring, stir well, heat to 60°C, let stand for 24 hours, filter, recover ethanol under ...

Embodiment 2

[0042] Pass the raw and auxiliary materials through a 100-mesh sieve, take 500g of calcium dobesilate and 5g of pueraria flavonoids, add microcrystalline cellulose and sodium carboxymethyl starch and mix evenly, add 15% PVP to make a soft material, use 16-24 mesh Sieve granulation, ventilate and dry the wet granules at 50-80°C, sieve the granules with 16-24 mesh, add magnesium stearate and mix evenly, measure the content of the main drug in the granules and seal them in a capsule packing machine to make 1000 granules .

[0043] Wherein, the extraction method of Pueraria flavonoids is as described in Example 1.

Embodiment 3

[0045] Pass the raw and auxiliary materials through a 100-mesh sieve, take 100g of calcium dobesilate and 500g of puerarin, add microcrystalline cellulose and sodium carboxymethyl starch and mix evenly, add 15% PVP in an appropriate amount to make a soft material, use 16-24 mesh Sieve granulation, ventilate and dry the wet granules at 50-80°C, sieve the granules with a 16-24 mesh, add magnesium stearate and mix evenly, measure the content of the main drug in the granules, and then compress into tablets to make 2000 granules.

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Abstract

The present invention relates to medicine composition for treating microcirculation dysfunction and its preparation, and features that the medicine composition contains calcium phenolsulfonate in 10-1000 weight portions and pueraria flavonoid in 10-1000 weight portions as active medicine components.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating various diseases caused by microvascular circulation disorder and a preparation method thereof. The composition contains calcium dobesilate and kudzu root flavonoids as active ingredients, and is mainly used for treating various diseases caused by microvascular circulation disorders, especially for retinopathy caused by diabetes, heart disease caused by microcirculation disorders, Brain and kidney diseases, such as the treatment of syndromes such as glomerular arteriosclerosis and varicose veins. Background technique [0002] Diabetes is a group of common metabolic endocrine diseases. There are 125 million diabetic patients in the world, and the number of diabetic patients in my country has reached 40 million. The World Health Organization lists diabetes as one of the three difficult diseases. Due to the high blood sugar concentration in diabetic patients, excess glucose is metabolized...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K9/00A61K31/185A61K36/488A61P9/10
Inventor 王振国贾志丹曹树煜王淑娟韩春磊周颖
Owner SINOPHARM A THINK PHARMA
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