Medicine composition for treating microcirculation dysfunction and its preparing method
A circulatory disorder and composition technology, applied in the field of pharmaceutical compositions for various diseases, can solve problems such as difficulty in obtaining satisfactory therapeutic effects and the like
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Embodiment 1
[0039] Pass the raw and auxiliary materials through a 100-mesh sieve, take 5g of calcium dobesilate and 500g of pueraria flavonoids, add microcrystalline cellulose and sodium carboxymethyl starch and mix evenly, add 15% PVP to make a soft material, use 16-24 mesh Sieve and granulate, dry the wet granules at 50-80°C, sieve the granules with 16-24 mesh, add magnesium stearate and mix evenly, measure the content of the main drug in the granules, and then compress into tablets to make 2000 tablets.
[0040] Among them, the extraction method of Pueraria flavonoids is as follows: Take 10 kg of Pueraria root, add 6 times the amount of water to decoct three times, the first time is 1.0 hours, the second and third times are 0.5 hours, filter respectively, combine the filtrates, and concentrate to a relative density of 1.08 ~ 1.14 (55°C) clear paste, add 2.8 times of ethanol to the clear paste while stirring, stir well, heat to 60°C, let stand for 24 hours, filter, recover ethanol under ...
Embodiment 2
[0042] Pass the raw and auxiliary materials through a 100-mesh sieve, take 500g of calcium dobesilate and 5g of pueraria flavonoids, add microcrystalline cellulose and sodium carboxymethyl starch and mix evenly, add 15% PVP to make a soft material, use 16-24 mesh Sieve granulation, ventilate and dry the wet granules at 50-80°C, sieve the granules with 16-24 mesh, add magnesium stearate and mix evenly, measure the content of the main drug in the granules and seal them in a capsule packing machine to make 1000 granules .
[0043] Wherein, the extraction method of Pueraria flavonoids is as described in Example 1.
Embodiment 3
[0045] Pass the raw and auxiliary materials through a 100-mesh sieve, take 100g of calcium dobesilate and 500g of puerarin, add microcrystalline cellulose and sodium carboxymethyl starch and mix evenly, add 15% PVP in an appropriate amount to make a soft material, use 16-24 mesh Sieve granulation, ventilate and dry the wet granules at 50-80°C, sieve the granules with a 16-24 mesh, add magnesium stearate and mix evenly, measure the content of the main drug in the granules, and then compress into tablets to make 2000 granules.
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