Dispersing tablets of Liuwei-dihuang extract or its add-substract components, and its prepn. method
A technology of Liuwei Dihuang and dispersible tablets, applied in the field of medicine, can solve the problems of inconvenient storage, transportation and carrying, poor stability, large volume and the like, and achieve the effects of long-term storage quality stability, improved dispersion uniformity and simple preparation process
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Embodiment 1
[0052] Calculated on the basis of preparing 1000 tablets, the weight composition of raw materials is as follows: 250g of extract made from Liuwei Dihuang, 120g of lactose, 18g of low-substituted hydroxypropyl cellulose, 24g of cross-linked polyvinylpyrrolidone, 135g of microcrystalline cellulose, Magnesium stearate 3g, made into 1000 tablets in total. Tablet weight 450mg, hardness 3kg.
[0053] Take the extract, lactose, microcrystalline cellulose, low-substituted hydroxypropyl cellulose and cross-linked polyvinylpyrrolidone of the formula amount, mix well; use 10% ethanol to make soft material, granulate with 24 mesh sieve, wet granulate at 50 Dry at ~60°C; sieve through a 24-mesh sieve, add magnesium stearate, mix well, and press into tablets.
[0054] Uniformity of dispersion: take 2 dispersible tablets, put them in 100ml of water and shake, in 20±1°C water, they will completely disintegrate within 3 minutes and pass through the No. 2 sieve (Appendix IA, Part Two, Chinese ...
Embodiment 2
[0056] Calculated on the basis of preparing 1000 tablets, the weight composition of raw materials is as follows: 225g of extract made from Liuwei Dihuang, 197g of cross-linked polyvinylpyrrolidone, 12g of microcrystalline cellulose, 11g of aspartame, 2g of menthol, stearin Magnesium acid 2g, made 1000 tablets altogether. Tablet weight 450mg, hardness 3kg.
[0057] Preparation method: pass each component through a 100-mesh sieve, mix the extract with cross-linked polyvinylpyrrolidone, microcrystalline cellulose, aspartame, menthol, etc., and then use 90% ethanol as a wetting agent to prepare Soft material, granulated with 18-24 mesh sieve, dried wet granules at 50-80°C, granulated through 18-24 mesh sieve, mixed with magnesium stearate, pressed into tablets to obtain the finished product.
[0058] Uniformity of dispersion: take 2 dispersible tablets, put them in 100ml of water and shake, in 20±1°C water, they will completely disintegrate within 3 minutes and pass through the N...
Embodiment 3
[0060] Calculated on the basis of preparing 1000 tablets, the weight composition of raw materials is as follows: 250g of extract made from Liuwei Dihuang, 22g of sodium carboxymethyl starch, 22g of low-substituted hydroxypropyl cellulose, 210g of microcrystalline cellulose, and aspartame 12g, magnesium stearate 3g, micropowder silica gel 2g, made into 1000 tablets in total.
[0061] Preparation method: pass each component through a 100-mesh sieve, first weigh the extract, sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose, microcrystalline cellulose, and aspartame and mix them evenly, and then use 90% ethanol Used as a wetting agent to make soft materials, granulated with a 18-24 mesh sieve, dried at 50-80°C, granulated through a 18-24 mesh sieve, mixed with magnesium stearate, and pressed into tablets to obtain finished product.
[0062] Uniformity of dispersion: take 2 dispersible tablets, put them in 100ml of water and shake, in 20±1°C water, they will co...
PUM
| Property | Measurement | Unit |
|---|---|---|
| Sheet weight | aaaaa | aaaaa |
| Hardness | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
Login to View More