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Method of preparing polymer nanometerl micron ball assisted by ultrasonic wave

An ultrasonic-assisted, polymer technology, used in pharmaceutical formulations, non-active ingredients medical preparations, etc., can solve the problems of unsuitable hydrophobic polymers and high temperature, and achieve the effects of easy implementation, simple operation and wide application value.

Inactive Publication Date: 2006-11-29
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among these several methods, dialysis is usually only suitable for amphiphilic polymers, not for hydrophobic polymers
The microspheres produced by the melting method have a narrow particle size range, but require a higher temperature, and are only suitable for drugs with high thermal stability.

Method used

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  • Method of preparing polymer nanometerl micron ball assisted by ultrasonic wave
  • Method of preparing polymer nanometerl micron ball assisted by ultrasonic wave
  • Method of preparing polymer nanometerl micron ball assisted by ultrasonic wave

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Add 180 parts of tetrahydrofuran to 1 part (by mass) of poly(L-lactide) with a molecular weight of 100,000. At 25°C and normal pressure, after ultrasonication in a 100W ultrasonic instrument for 5 minutes, at normal temperature and 1 atmosphere The tetrahydrofuran is exhausted with a water pump to obtain poly(L-lactide) nano-microspheres. The morphology of the nanospheres is determined by scanning electron microscopy (SEM), (see figure 1 ), the particle size distribution is measured by a particle size analyzer (ZetaSizer). Average particle size: 660.2 nm, dispersion: 0.349.

Embodiment 2

[0020] Add 180 parts of tetrahydrofuran to 1 part (by mass) of poly(D, L-lactide) with a molecular weight of 150,000, and at 40°C and normal pressure, after ultrasonication in a 50W ultrasonic instrument for 3 minutes, at 10°C, Under 1 atmosphere pressure, the tetrahydrofuran was exhausted with a water pump to obtain poly(D,L-lactide) microspheres. The particle size distribution of the microspheres was determined by a ZetaSizer. Average particle size: 3236 nm, dispersion: 0.332.

Embodiment 3

[0022] Add 130 parts of tetrahydrofuran and 50 parts of ultrapure water to 1 part (by mass) of polycaprolactone (PCL) with a molecular weight of 30,000, and at 25 ° C and normal pressure, after ultrasonication in a 50W ultrasonic instrument for 5 minutes, install Put it into a dialysis bag with a molecular weight cut-off of 8000-12000, dialyze in ultrapure water to remove tetrahydrofuran, and then remove water with a lyophilizer at 20°C and normal pressure to obtain polycaprolactone (PCL) microspheres. The particle size distribution of the microspheres was determined by a ZetaSizer. Average particle size: 1941 nm, dispersion: 0.371.

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Abstract

An ultrasonic aided process for preparing the polymer nano-ball (or micron-balls) used for the release controllable system of medicine includes such steps as mixing polymer with disperser, ultrasonic dispersing and removing disperser to obtain target product.

Description

technical field [0001] The invention relates to a method for preparing polymer nanometer and microspheres by means of ultrasonic auxiliary means, and belongs to the field of polymer materials. Background technique [0002] So far, the nano- and micro-particle materials used for drug controlled release are mainly polymers, which can be divided into natural polymer materials and synthetic polymer materials according to the synthesis method; biodegradable polymer materials and non-biodegradable polymer materials according to the degradation performance. Polymer Materials. The rapid development of nanotechnology has led to a new stage in the research of drug dosage forms. At present, in the research of all polymer drug controlled release systems, nanometer and micro particle drug controlled release systems account for a large proportion. [0003] At present, the common preparation methods of nano / microspheres include methods such as dialysis, emulsion polymerization, evaporatio...

Claims

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Application Information

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IPC IPC(8): C08J3/12C08J3/28C08L67/04C08L69/00A61K47/34
Inventor 卓仁禧程巳雪邹涛林光缪志梅
Owner WUHAN UNIV