Application of teprenone for preparing medicine for treating and/or preventing glaucoma

A technology of lateral geniculate body and teprenone, which is applied in the application field of teprenone in the preparation of glaucoma preventive and/or therapeutic drugs, can solve the problems that the protection of neurons in the visual pathway does not play a role, and the like

Inactive Publication Date: 2011-07-27
BEIJING TONGREN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] However, neither raising the body temperature nor causing a sublethal dose of hypoxia to induce the production of this protective protein is not suitable for humans, and some people have proposed a strategy of using laser thermal stimulation through the pupil to induce the retina to produce the above protective protein. (Mainster MA, Reichel E. Transpupillary thermotherapy for age-related macular degeneration: long-pulse photocoagulation, apoptosis, and heat shock proteins. Ophthalmic Surg. Lasers 2000; 31: 359-73.), however, this method can only induce retinal Local production of these protective proteins has no effect on the protection of neurons in the entire visual pathway

Method used

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  • Application of teprenone for preparing medicine for treating and/or preventing glaucoma
  • Application of teprenone for preparing medicine for treating and/or preventing glaucoma
  • Application of teprenone for preparing medicine for treating and/or preventing glaucoma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Example 1. Detection of the effect of oral administration of GGA on the expression of HSP70 in the lateral geniculate body of rats

[0049] 1. Western blot detection of the effect of oral GGA on the expression of HSP70 in the lateral geniculate nucleus (LGN) of rats

[0050] 1. Western blot detection time curve of HSP70 expression in rat LGN after oral vehicle, GGA and heat shock treatment

[0051] The experimental rats were randomly divided into two groups: N group (normal control group, n=6) and T group (treatment group); T group was further divided into: VT group (vehicle administration group), GT group (GGA administration group) and HT group (heat shock treatment group).

[0052] The administration method is: GGA (400mg / kg) or excipient (containing 5% lactose and 0.008% vitamin E) is dissolved in 5mL / kg normal saline and gavaged, and the normal control group is gavaged with normal saline (5mL / kg ). The heat shock treatment method is: chloral hydrate (40mg / 100g bo...

Embodiment 2

[0093] Example 2. Detection of the effect of oral administration of GGA on the lateral geniculate body of rats after optic nerve transection

[0094] Experiments in Implementation 1 proved that oral administration of GGA can induce the expression of HSP70 in the LGN, but whether the upregulation of HSP70 induced by GGA has a neuroprotective effect on the LGN of the optic nerve transection model is still unclear. Microalbumin (Parvalbumin, PV) was used to selectively mark the Following neurons (Yucel YH, Zhang Q, Gupta N, Kaufman PL, Weinreb RN. Loss of neurons in magnocellular and parvocellular layers of the lateralgeniculate nucleus in glaucoma. Arch. Ophthalmol 2000; 118: 378-84.), by detecting PV The distribution of positive cells, their number and area, and the determination of mitochondrial cytochrome oxidase (CCX) (Wong-Riley MT. Cytochrome oxidase: an endogenous metabolic marker for neuronal activity. Trends Neurosci. 1989; 12:94-101.) to detect the effect of GGA on LGN...

Embodiment 3

[0124] Embodiment 3, detect the influence of oral GGA on retinal ganglion cells after optic nerve cutting in rats

[0125] The pathological basis of visual damage caused by glaucoma is the progressive death of retinal ganglion cells (RGCs) and loss of optic nerve fibers. The death of RGCs often leads to irreversible damage to visual function. Therefore, the key to glaucoma treatment is to prevent optic nerve damage and protect visual function. . The experiment in Example 2 proves that GGA has a protective effect on the LGN damage caused by optic nerve cutting, but whether GGA can also play a protective role on the RGCs damage induced by optic nerve cutting, the following experiments are now used to detect the effect of oral GGA on rats after optic nerve cutting. Effect of RGCs.

[0126] 1. Detection of the effect of oral administration of GGA on the expression of HSP70 in rat retina

[0127] The experimental rats were randomly divided into 4 groups: N (normal control group),...

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Abstract

An application of teprenone in preparing the medicine GGA for preventing and treating glaucomas is disclosed. Its advantages are high curative effect, high safety and low cost.

Description

technical field [0001] The present invention relates to new applications of compounds, in particular to the application of teprenone (Geranylgeranylacetone, GGA) in the preparation of preventive and / or (" / " means or) or therapeutic drugs for glaucoma. Background technique [0002] Glaucoma is a group of optic nerve damage diseases caused by absolute or relative elevation of intraocular pressure. With the effective control of infectious blinding diseases, corneal transplantation and cataract surgery, glaucoma has become the most common irreversible blinding disease worldwide (Foster PJ, Johnson GJ. Glaucoma in China: howbig is the problem? Br. J. Ophthalmol 2001;85:1277-82.). [0003] At present, the treatment methods for elevated intraocular pressure in glaucoma mainly include drugs, laser, surgery, etc., and good curative effects have been obtained in clinical practice. However, studies have found that even if the intraocular pressure of glaucoma patients is well controll...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/121A61P27/06
Inventor 王宁利赵丽姜利斌李俊发卢青君李辽青范尔钟王玲王怀洲王春芳龙彩霞韩松李爱琴卢弘陈凤华
Owner BEIJING TONGREN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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