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Method for processing monkshood

A technology for traditional Chinese medicine and aconite, which is applied in the field of processing traditional Chinese medicine aconite, can solve the problems of unfavorable wide application of aconite and high requirements for large-scale production.

Active Publication Date: 2007-01-31
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method is easy to introduce other chemical components, which is unfavorable for the wide application of aconite; high-pressure cooking, that is, pressure cooking at 110 ° C, has good efficacy and low toxicity, but it requires higher conditions for large-scale production.

Method used

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Examples

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Effect test

Embodiment 1

[0016] Soak the traditional Chinese medicine aconite product in water for 12 hours at normal temperature, take it out and dry it in the shade, and put it in an oven for drying at 200°C for 25 minutes to obtain the processed aconite product.

[0017] Get 0.4 grams of powder (passed through a No. 3 sieve) of processed aconite processed by the method, add an appropriate amount of 10% ammonia water, and use an appropriate amount of ether for ultrasonic extraction for 30 minutes. Diluted with methanol by electrospray mass spectrometry (ESIMS). The main components of aconitine in the processed products of traditional Chinese medicine are aconitine (m / z 646), mesoaconitine (m / z 632), hypoaconitine (m / z 616), benzoyl mesoaconitine (m / z 590), benzoyl aconitamine (m / z 604), aconitine deacetate (m / z 586), mesoaconitine deacetate (m / z 572), 8-oil Acid-benzoyl aconitamine (m / z 836). After analysis by high performance liquid chromatography (HPLC), aconitine, mesoaconitine and hypoaconitin...

Embodiment 2

[0019] Soak the raw aconite product of traditional Chinese medicine in water for 18 hours at normal temperature, take it out and dry it in the shade, and dry it in an oven at 220°C for 20 minutes to obtain the processed aconite product.

[0020] Get 0.4 grams of powder (passed through a No. 3 sieve) of processed aconite processed by the method, add an appropriate amount of 10% ammonia water, and use an appropriate amount of ether for ultrasonic extraction for 30 minutes. Diluted with methanol by electrospray mass spectrometry (ESIMS). The main components of aconitine in the processed products of traditional Chinese medicine are aconitine (m / z 646), mesoaconitine (m / z 632), hypoaconitine (m / z 616), benzoyl mesoaconitine (m / z 590), benzoyl aconitamine (m / z 604), aconitine deacetate (m / z 586), mesoaconitine deacetate (m / z 572), 8-oil Acid-benzoyl aconitamine (m / z 836). After analysis by high performance liquid chromatography (HPLC), aconitine, mesoaconitine and hypoaconitine co...

Embodiment 3

[0022] Soak the raw aconite product of traditional Chinese medicine in water for 24 hours at room temperature, take it out and dry it in the shade, and dry it in an oven at 240°C for 15 minutes to obtain the processed aconite product.

[0023] Get 0.4 grams of powder (passed through a No. 3 sieve) of processed aconite processed by the method, add an appropriate amount of 10% ammonia water, and use an appropriate amount of ether for ultrasonic extraction for 30 minutes. Diluted with methanol by electrospray mass spectrometry (ESIMS). The main components of aconitine in the processed products of traditional Chinese medicine are aconitine (m / z 646), mesoaconitine (m / z 632), hypoaconitine (m / z 616), benzoyl mesoaconitine (m / z 590), benzoyl aconitamine (m / z 604), aconitine deacetate (m / z 586), mesoaconitine deacetate (m / z 572), 8-oil Acid-benzoyl aconitamine (m / z 836). After analysis by high performance liquid chromatography (HPLC), aconitine, mesoaconitine and hypoaconitine coul...

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Abstract

An improved process for processing the raw aconite root in order to decrease its poison and increase its curative effect includes such steps as immersing in water, drying in the air, and high-temp baking to obtain prepared aconite root.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a method for processing traditional Chinese medicine aconite. technical background [0002] Aconitum carmichaeli Debx., a traditional Chinese medicine, is the root of Aconitum carmichaeli Debx. Its taste is pungent and sweet, and its nature is hot and poisonous. It is the main medicine for supplementing Yuanyang, and it has the functions of restoring yang and rescuing adversity, expelling cold and dampness, and warming and supporting kidney yang. Modern studies have shown that aconite plays a role in strengthening the heart, lowering blood pressure, slowing down the heart rate, analgesia, anti-inflammation, local anesthesia, anti-cold, and stimulating the adrenal cortex system. Traditional Chinese medicine aconite contains various chemical components such as diterpenoid alkaloids and polysaccharides. Diterpene alkaloids include diester alkaloi...

Claims

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Application Information

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IPC IPC(8): A61K36/714A61P9/12A61P9/06A61P29/00A61K125/00
Inventor 刘淑莹越皓皮子凤刘志强宋凤瑞王淑敏
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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