Clonidine, weekly-effect, skin-permeable and control-released plaster

A clonidine transdermal technology, which is applied in the field of clonidine weekly transdermal controlled-release patch, can solve the problems of skin incompatibility, poor adhesiveness, allergies and inflammation easily, and achieve reduced total area and good viscosity Effect

Inactive Publication Date: 2007-02-14
LKF GUANGDONG MEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] US Pat.4,559,222 has disadvantages: the use of polyisobutylene pressure-sensitive adhesive is not compatible with the skin, the area is still large, and it is easy to cause allergies and inflammation; the adhesiveness is poo...

Method used

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  • Clonidine, weekly-effect, skin-permeable and control-released plaster

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0017] 1. Preparation of Acrylate-Ethylene Acetate Copolymer Pressure Sensitive Adhesive

[0018] Monomer components:

[0019] 2-Ethylhexyl Acrylate (2-Ethylhexyl Acrylate) (2-EHA) 75%

[0020] Acrylic Acid (AA) 5%

[0021] Vinyl Acetate (Vac) 20%

[0022] Solvent composition:

[0023] Cyclohexane 100%

[0024] Initiator: BPO or AIBN at 0.4% of the monomer.

[0025] According to the above-mentioned monomer and solvent components, use the traditional solution-type acrylate pressure-sensitive adhesive polymerization process to polymerize into a non-cross-linked pressure-sensitive adhesive solution (the nominal solid content can be calculated as 35%)

[0026] Polymerization process:

[0027] Add 100 parts by mass (wt.%) of the above three mixed monomer components and 80 parts of the above-mentioned solvent into a multi-necked flask equipped with a reflux condenser, a stirrer, a thermometer, a nitrogen inlet tube and a dropping funnel, and heat under stirring And nitrogen g...

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Abstract

A release controlled percutaneous adhesive of clonidine with long curative period (7 days) is prepared from clonidine, the pressure-sensitive adhesive prepared from solvent(cyclohexane)-type acrylate-vinyl acetate copolymer, and release controlling membrane prepared from modified ethene-vinyl acetate copolymer.

Description

technical field [0001] The clonidine weekly-effect transdermal controlled-release patch of the invention relates to a medicinal transdermal therapeutic system (Transdermal Therapeutic System TTS), also known as a patch. It is used for the transdermal administration of clonidine in the treatment of hypertension, child tics, ADHD, smoking cessation, drug abstinence, migraine, analgesia, and menopausal syndrome. Background technique [0002] Clonidine is a central a2 receptor agonist, which can reduce the activity of peripheral sympathetic nerves and cause blood pressure by inhibiting the vasomotor center. Oral clonidine tablets were launched in the mid-1960s. Because of its definite curative effect, long-term use, effective protection of target organs and beneficial metabolism without side effects, long-term use is safe and reliable, so it was widely used clinically in the world in the 1970s and 1980s. Included in national pharmacopoeias and essential drug lists. Since the 1...

Claims

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Application Information

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IPC IPC(8): A61K31/4166A61K9/70A61P9/12A61P25/00A61P15/12
Inventor 吴日升
Owner LKF GUANGDONG MEDICAL
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