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Vinpocetine drop pills and its preparation method

A technology of vinpocetine and Ting drop pills, which is applied in the directions of pill delivery, cardiovascular system diseases, drug combination, etc., can solve the problems of low bioavailability, affecting drop pills, long disintegration time, etc., and achieves less excipient dosage. , Pill volume is small, good compliance effect

Inactive Publication Date: 2007-02-28
姜昱
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Since vinpocetine is almost insoluble in water, there are many vinpocetine tablets currently used clinically, but the preparation type is relatively traditional. This traditional preparation has long disintegration time, slow absorption, and low bioavailability, which affect the curative effect. How to overcome these shortcoming, make the rapid onset of medicine become the subject of people's active research, dripping pill is a kind of spherical pill that utilizes solid dispersion technology to drop to form, and it utilizes water-soluble carrier to improve the solubility and dissolution rate of medicine, improve The absorption speed and the absorption amount of medicine, thereby improve the bioavailability of medicine and improve the curative effect of medicine, but composition and preparation method between the active ingredient of medicine and adjuvant are the factors that affect drop pills, the present invention is just based on this Forming

Method used

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  • Vinpocetine drop pills and its preparation method

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Embodiment 1

[0025] prescription composition

[0026] Preparation process: put 20g of polyethylene glycol 6000 in the chemical material tank, the temperature of the chemical material tank is 90°C, make it melt, stir evenly, add 5g prescription amount of vinpocetine that has been ultra-micronized and passed through a 150-mesh sieve, and stir evenly; Preheat the dripping pill machine, the temperature of the liquid storage chamber, that is, the dripping temperature, is constant at 95°C, the condensing medium is liquid paraffin, pre-cooled to a temperature of 8-12°C, and the distance from the dripper to the condensate is adjusted to 25cm. Pour the medicinal liquid into the liquid storage chamber, activate the valve, drop the medicinal liquid into the condensate, collect the dripping pills at the collection port, and absorb the surface condensate to obtain the product.

Embodiment 2

[0028] prescription composition

[0029] Preparation process: Put 22g of polyethylene glycol 6000 and 8g of polyethylene glycol 4000 in the material tank, the temperature of the material tank is 85°C, melt them, stir evenly, add 5g of vinpocetine dissolved in a small amount of ethanol, and stir Uniform; preheat the dripping pill machine, the temperature of the liquid storage chamber, that is, the dripping temperature, is constant at 90°C, the condensing medium is dimethyl silicone oil, pre-cooled to a temperature of 8-12°C, and the distance from the dripper to the condensate is adjusted to 30cm. After the smell of ethanol disappears, pour the liquid medicine into the liquid storage chamber, activate the valve, drop the medicine liquid into the condensate, collect the dripping pills at the collection port, and absorb the surface condensate to obtain the product.

Embodiment 3

[0031] prescription composition

[0032] Preparation process: put 2g of poloxamer, 20g of polyethylene glycol 4000, and 15g of polyethylene glycol 6000 in a chemical tank, the temperature of the chemical tank is 95°C, melt it, stir it evenly, add 10g of the prescription Vinpocetine that has been micronized through a 150-mesh sieve and stirred evenly; preheat the dropping pill machine, the temperature of the liquid storage chamber, that is, the dripping temperature, is constant at 95°C, the condensing medium is dimethyl silicone oil, and the temperature is pre-cooled to 8-10°C. °C, adjust the distance from the dripper to the condensate to 25cm. Pour the medicinal liquid into the liquid storage chamber, activate the valve, drop the medicinal liquid into the condensate, collect the dripping pills at the collection port, and absorb the surface condensate to obtain the product.

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Abstract

The invention relates to a drop pill preparation with Vinpocetine as the main ingredient and process for preparing it, compared with the existing dosage forms, the drop pill preparation has the advantages of quick-effectiveness, high biological availability, good taste, and fitting for mass production.

Description

technical field [0001] The invention relates to a new preparation of vinpocetine and a preparation process thereof, in particular to a vinpocetine dropping pill preparation and a preparation method thereof. Background technique [0002] Vinpocetine (vinpocetine, VIN) is a derivative of the indole alkaloid vincamine (vincamine) extracted from Apocynaceae vinca (Vinca minorL.), and its structural formula is as follows: [0003] [0004] Vinpocetine belongs to the indole alkaloids, which can easily enter the brain through the blood-brain barrier. It was first successfully developed by the Hungarian Gedeon Richter company. It is effective for sequelae, hypertension, and hyperviscosity of coronary heart disease, and it is also of great value for studying the pathophysiology of cerebrovascular diseases. It is clinically used to treat mental or neurological symptoms caused by cerebral blood circulation disorders, such as memory impairment, aphasia, movement disorders, dizziness...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4375A61K9/20A61P9/10
Inventor 王国斌姜昱
Owner 姜昱
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