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Aporphine and use of oxidized aporphine alkaloid

A technology for oxidizing aporphi and alkaloids, which is applied in the fields of anti-inflammation and immunosuppression of aporphi and oxidized aporphim alkaloids, and can solve the problems of in-depth research on the composition and content of total alkaloid monomers

Inactive Publication Date: 2007-03-07
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The protected total alkaloid extraction process is only a general extraction method for alkaloids, and no in-depth research has been carried out on the monomer components and content of total alkaloids. At the same time, no relevant biological tests have been carried out on total alkaloids to verify the new The extraction part of the single medicine has similar biological effects to the original single medicine or the compound

Method used

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  • Aporphine and use of oxidized aporphine alkaloid
  • Aporphine and use of oxidized aporphine alkaloid
  • Aporphine and use of oxidized aporphine alkaloid

Examples

Experimental program
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Effect test

Embodiment 1

[0068] 1000 grams of Zhanshanfeng cane or root (collected from Jiangxi), heat extraction 3 times with 2% sulfuric acid aqueous solution (3800 milliliters for the first time, 3000 milliliters for the second time, 3000 milliliters for the third time), 3 hours each time, filter Then apply D101 macroporous resin, wash with water first, then wash with 20%, discard, elute with 50% ethanol aqueous solution, and concentrate under reduced pressure to obtain 6.4 grams of total alkali sulfate sample. The content of total alkaloid sulfate (calycinine sulfate as reference substance, weight ratio) measured by ultraviolet spectrophotometry is 53.4%. The contents of calycinine sulfate and xylopine sulfate measured by HPLC were 6.4% and 4.8%, respectively.

Embodiment 2

[0070] 1000 grams of Zhanshanfeng cane or root (collected from Jiangxi), heat extraction 3 times with 2% sulfuric acid aqueous solution (3800 milliliters for the first time, 3000 milliliters for the second time, 3000 milliliters for the third time), 3 hours each time, filter Finally, adjust the pH to 8-9 with ammonia water, then adjust to 30% ethanol solution with ethanol, apply D101 macroporous resin, elute with 30% and 90% ethanol aqueous solution, and concentrate 90% of the eluted fraction under reduced pressure to obtain Total alkali sample 4.9 grams. The total alkaloid content (with calycinine as reference substance, weight ratio) measured by ultraviolet spectrophotometry is 59.8%. The contents of calycinine and xylopine measured by HPLC were 5.7% and 5.3%, respectively.

Embodiment 3

[0072] 1000 grams of Zhanshanfeng cane or root (collected from Jiangxi), heat extraction 3 times with 80% ethanol aqueous solution (3800 milliliters for the first time, 3000 milliliters for the second time, 3000 milliliters for the third time), 3 hours each time, filter After concentrating to the extractum, the extractum was kneaded and dissolved with 200 ml of 2% sulfuric acid, filtered and cleared onto D101 macroporous resin, washed with water first, then eluted with 20%, 50% ethanol aqueous solution, and washed with 50% ethanol aqueous solution. The dedistillation fraction was concentrated under reduced pressure to obtain 6.0 g of total alkali salt sample. The content of total alkaloid sulfate (calycinine sulfate as reference substance, weight ratio) measured by ultraviolet spectrophotometry is 51.8%. The contents of calycinine sulfate and xylopine sulfate measured by HPLC were 6.0% and 5.1%, respectively.

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Abstract

The invention discloses an apo-phenanthrene and application of apo-phenanthrene oxide biological alkaline, which is characterized by the following: treating self-immune disease through inhibiting the proliferation of T, B lymph cell; avoiding host-resistance disease or allergic disease due to marrow transplantation.

Description

technical field [0001] The present invention relates to the use of the total alkaloids and alkali salts of the traditional Chinese medicine Zanshanfeng, and more specifically refers to the anti-inflammatory and immunosuppressive uses of aporphyllin and oxidized aporphyllin alkaloids obtained from them. technical background [0002] Zanshanfeng Fissistigma oldhamii (Hemsl.) Merr. Also known as melon wood, patchouli vine, is the root or cane of the Annonaceae (Annonaceae) plant Hemsl. Distributed in Zhejiang, Jiangxi, Fujian, Taiwan, Hunan, Guangdong, Hainan, Guangxi, Yunnan and other places. It has the effects of expelling wind and dampness, promoting blood circulation and relieving pain. It is mainly used to treat rheumatic arthralgia, low back pain, stomach pain, and bruises [edited by the editorial board of "Chinese Materia Medica". Zhonghua Materia Medica [M]. The second volume, Shanghai: Shanghai Science and Technology Press, 1997, 3.1594-1595]. Zanshanfeng is a folk h...

Claims

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Application Information

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IPC IPC(8): C07D221/18C07D491/056A61K31/4741A61P37/06A61P37/08A61P19/02A61P3/10A61P43/00
Inventor 胡立宏左建平郑宗平周宇钟相根
Owner SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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