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Active carbon oral suspension liquid, preparing method and its use

A technology of oral suspension and activated carbon, which is applied in the direction of pharmaceutical formulas, medical preparations of non-active ingredients, anti-toxins, etc., can solve the problems of difficult drug dispersion and accurate dosage, so as to improve the practical value and improve the success of rescue rate, improve the effect of taste

Inactive Publication Date: 2007-04-11
北京云威科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of the suspension is that the drug is not easy to disperse evenly, and the dosage is not easy to be accurate. In order to ensure the safety of the drug, it is not suitable to make a suspension for toxic drugs or drugs with small doses.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Take 25kg of activated carbon powder, 80L of glycerin, 4.2L of propylene glycol, 9.6kg of sucrose, 0.48kg of citric acid or citric acid, and an appropriate amount of water. Add glycerin into the ball mill, add medicinal charcoal in batches, grind thoroughly, and the diameter of more than 80% of the particles is not greater than 150 μm, and stand still. Then add all the remaining glycerin and propylene glycol, stir well to form a suspension system, then dissolve sucrose and citric acid or citric acid in a small amount of water, continue stirring and add to the suspension system, and finally add water to the full amount (100L), fully Stir well and divide into packages. The relative density of the suspension is 1.2, the pH value is 5.5, and the sedimentation volume ratio is 0.93.

Embodiment 2

[0025] Slowly add 150g of ground activated carbon powder into a container containing 600ml of glycerin in batches, stir continuously during the addition to make it evenly mixed into a suspension system, add water and stir continuously until the total volume is 1000ml, and let stand. The relative density of the suspension is 1.18, the pH value is 5, and the sedimentation volume ratio is 0.96.

Embodiment 3

[0027] Slowly add 200g of ground activated carbon powder into a container containing 800ml of glycerin and 20ml of propylene glycol in batches, stir continuously during the addition to make it evenly mixed into a suspension system, add water and stir continuously until the total volume is 1000ml, and let stand. The relative density of the suspension is 1.19, the pH value is 5.3, and the sedimentation volume ratio is 0.95.

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PUM

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Abstract

The invention provides an active carbon oral suspension for absorbing poison being through oral poisoning and preparation thereof, and said suspension comprising active carbon powder 15%-25%(w / v), glycerine 60%-80%(v / v) and right amount of water , its relative density is 1.15-1.25, pH value is 4.5-6.5,settling volume ratio is no lower than 0.90. Active carbon oral suspension described hereinabove can also be added propylene 2%-5%(v / v). Also can adding sucrose 5%-10%(w / v)and citric acid 0.2%-1% (w / v). Additionally said invention relates to application of said oral suspension in absorbing poison being through oral poisoning.

Description

technical field [0001] The invention relates to a preparation method of activated carbon oral mixture and suspension and application thereof. The activated carbon suspension can be used for rescuing and treating people or animals who are poisoned by mouth, and absorbs toxic substances in the gastrointestinal tract. Background technique [0002] In my country, the fatality rate of pesticide poisoning and drug poisoning has been among the top 5 of all diseases for more than ten years, and the most poisoned patients are through oral poisoning. In the rescue and treatment of patients with acute oral poisoning, oral activated charcoal is one of the most important basic treatment measures. However, in the actual clinical treatment of poisoning, there are no detoxification substances suitable for clinical emergency use, and activated carbon is rarely used. The main reason is that the dosage form of medical activated carbon in my country is not suitable for clinical use. The dose of...

Claims

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Application Information

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IPC IPC(8): A61K33/44A61K47/10A61P39/02
Inventor 廖幼鸣迟艾军王海燕王红赵颖涛
Owner 北京云威科技有限公司
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