Glutathione calcium chelate and its preparing method, use and composition
A technology of glutathione and chelated calcium, which is applied in drug combinations, chemical instruments and methods, tripeptides, etc., can solve problems such as ideas and methods of high-efficiency calcium supplements that have not yet been proposed, and achieve vision protection, liver protection, The effect of radiation protection
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Embodiment 1
[0028] Prepare mass fraction 40% CaCl respectively 2 And mass fraction 30% glutathione (GSH) aqueous solution, pass into protective gas N 2 Under the conditions, take CaCl respectively 2 Solution 2.8g, GSH solution 30.7g, two solutions are mixed (wherein CaCl 2 GSH is 0.01mol, GSH is 0.03mol), the temperature of adjustment and control reaction is 80 ℃, and the reaction time is 4 hours, and the pH value of the mixed solution is adjusted to 8 with the dilute HCl that mass fraction is 1%, and leave standstill for 15 hours after fully reacting , add 170mL of ethanol solution with a mass fraction of 45% to the mixed solution, evaporate and concentrate the crystals at 120°C, and then centrifuge at 5000r / min, discard the supernatant, and place the precipitate obtained by centrifugation at 75°C for 1 hour in vacuum. That is, glutathione chelated calcium is obtained. According to the above-mentioned animal experiments, it is proved that this product has high-efficiency absorption, si...
Embodiment 2
[0030] Prepare the mass fraction of 10% CaCl respectively 2 and an aqueous solution with a mass fraction of 10% GSH, under the condition of passing through the protective gas Ar, respectively take CaCl 2 Solution 11.1g, GSH solution 30.7g, two solutions are mixed (wherein CaCl 2 0.01mol for GSH and 0.01mol for GSH); adjust and control the reaction temperature at 30°C, the reaction time is 1 hour, adjust the pH value of the mixed solution to 5 with a mass fraction of 0.5% dilute HCl, and let it stand for 10 hours after fully reacting ;Add 83.6mL of ethanol solution with a mass fraction of 25% to the mixed solution, evaporate and concentrate the crystals at a temperature of 100°C, and then centrifuge at 2000r / min, discard the supernatant; place the precipitate obtained by centrifugation in a vacuum at 60°C After drying for 6 hours, glutathione chelated calcium is obtained. According to the above-mentioned animal experiments, it is proved that this product has high-efficiency ab...
Embodiment 3
[0032] Prepare the mass fraction of 25% CaCl respectively 2 and an aqueous solution with a mass fraction of 17% GSH, in which CaCl 2 solution, GSH solution; when the protective gas N2 Under the conditions, take CaCl respectively 2 Solution 4.4g, GSH solution 27.1g, two solutions are mixed (wherein CaCl 2 0.01mol, GSH is 0.015mol), adjust and control the reaction temperature at 50°C, the reaction time is 2.5 hours, adjust the pH value of the mixed solution to 6.5 with the dilute HCl of 0.7% mass fraction, leave standstill for 12 hours after fully reacting, Add 94.5mL of ethanol solution with a mass fraction of 30% to the mixture, evaporate and concentrate the crystals at a temperature of 105°C, then centrifuge at 3000r / min, discard the supernatant; place the centrifuged precipitate at 65°C in a vacuum After drying for 4 hours, glutathione chelated calcium is obtained. According to the above-mentioned animal experiments, it is proved that this product has high-efficiency absor...
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