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Glutathione calcium chelate and its preparing method, use and composition

A technology of glutathione and chelated calcium, which is applied in drug combinations, chemical instruments and methods, tripeptides, etc., can solve problems such as ideas and methods of high-efficiency calcium supplements that have not yet been proposed, and achieve vision protection, liver protection, The effect of radiation protection

Inactive Publication Date: 2007-04-11
SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] At present, the research on glutathione and calcium supplementation preparations at home and abroad has made great progress, but no one has proposed the idea and method of combining the two to prepare a new high-efficiency calcium supplementation preparation

Method used

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  • Glutathione calcium chelate and its preparing method, use and composition

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Effect test

Embodiment 1

[0028] Prepare mass fraction 40% CaCl respectively 2 And mass fraction 30% glutathione (GSH) aqueous solution, pass into protective gas N 2 Under the conditions, take CaCl respectively 2 Solution 2.8g, GSH solution 30.7g, two solutions are mixed (wherein CaCl 2 GSH is 0.01mol, GSH is 0.03mol), the temperature of adjustment and control reaction is 80 ℃, and the reaction time is 4 hours, and the pH value of the mixed solution is adjusted to 8 with the dilute HCl that mass fraction is 1%, and leave standstill for 15 hours after fully reacting , add 170mL of ethanol solution with a mass fraction of 45% to the mixed solution, evaporate and concentrate the crystals at 120°C, and then centrifuge at 5000r / min, discard the supernatant, and place the precipitate obtained by centrifugation at 75°C for 1 hour in vacuum. That is, glutathione chelated calcium is obtained. According to the above-mentioned animal experiments, it is proved that this product has high-efficiency absorption, si...

Embodiment 2

[0030] Prepare the mass fraction of 10% CaCl respectively 2 and an aqueous solution with a mass fraction of 10% GSH, under the condition of passing through the protective gas Ar, respectively take CaCl 2 Solution 11.1g, GSH solution 30.7g, two solutions are mixed (wherein CaCl 2 0.01mol for GSH and 0.01mol for GSH); adjust and control the reaction temperature at 30°C, the reaction time is 1 hour, adjust the pH value of the mixed solution to 5 with a mass fraction of 0.5% dilute HCl, and let it stand for 10 hours after fully reacting ;Add 83.6mL of ethanol solution with a mass fraction of 25% to the mixed solution, evaporate and concentrate the crystals at a temperature of 100°C, and then centrifuge at 2000r / min, discard the supernatant; place the precipitate obtained by centrifugation in a vacuum at 60°C After drying for 6 hours, glutathione chelated calcium is obtained. According to the above-mentioned animal experiments, it is proved that this product has high-efficiency ab...

Embodiment 3

[0032] Prepare the mass fraction of 25% CaCl respectively 2 and an aqueous solution with a mass fraction of 17% GSH, in which CaCl 2 solution, GSH solution; when the protective gas N2 Under the conditions, take CaCl respectively 2 Solution 4.4g, GSH solution 27.1g, two solutions are mixed (wherein CaCl 2 0.01mol, GSH is 0.015mol), adjust and control the reaction temperature at 50°C, the reaction time is 2.5 hours, adjust the pH value of the mixed solution to 6.5 with the dilute HCl of 0.7% mass fraction, leave standstill for 12 hours after fully reacting, Add 94.5mL of ethanol solution with a mass fraction of 30% to the mixture, evaporate and concentrate the crystals at a temperature of 105°C, then centrifuge at 3000r / min, discard the supernatant; place the centrifuged precipitate at 65°C in a vacuum After drying for 4 hours, glutathione chelated calcium is obtained. According to the above-mentioned animal experiments, it is proved that this product has high-efficiency absor...

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Abstract

The present invention relates to glutathione calcium chelate and its preparation process, and features that under the protection of N2 or Ar, calcium chloride solution and glutathione solution in the calcium chloride and glutathione molar ratio of 1 / 3 to 1 are mixed and reacted, and the resultant is concentration crystallized and vacuum dried to obtain the product. The present invention also relates to the use and composition of glutathione calcium chelate. The glutathione calcium chelate of the present invention has high water solubility, high absorption rate, no irritation to gastrointestinal tract and no toxic side effect, and may be used for treating calcium deficiency caused diseases and as health food.

Description

technical field [0001] The present invention relates to a calcium chelate, specifically relates to a glutathione chelated calcium, and also relates to its preparation method, application and composition. Background technique [0002] Calcium is one of the essential macroelements for the human body and has many important physiological functions. According to the results of the third national nutritional survey conducted by the Chinese Medical Association and the Chinese Nutrition Society, due to many reasons such as eating habits, living habits, and age levels, calcium is still one of the most deficient nutrients in the Chinese population. With the improvement of people's living standards and the enhancement of health awareness, people are increasingly aware of the importance of calcium supplements to health. [0003] Studies have shown that calcium ions entering the human body first form chelates with polypeptides, dipeptides or amino acids on the small intestine wall, and ...

Claims

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Application Information

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IPC IPC(8): C07K5/08A61K38/06A61P1/16A61P17/16A61P17/18
Inventor 孙恢礼吴园涛李君林丽云翁世兵郑建禄
Owner SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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