Pharmaceutical composition with Meclofenoxate hydrochloride capable of preventing hydrolysis

A technology of meclofenoxate hydrochloride and composition, which is applied in the field of meclofenoxate hydrochloride pharmaceutical composition that can prevent hydrolysis stabilizers, can solve the problems of easy hydrolysis or deliquescence of meclofenoxate hydrochloride, and achieve the effect of preventing hydrolysis

Active Publication Date: 2007-04-25
GUANGDONG XIANQIANG PHARMA +2
View PDF1 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, meclofenoxate hydrochlor

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Each preparation containing active ingredient meclofenoxate hydrochloride 100mg is prepared, and the prescription of the pharmaceutical composition it uses is:

[0035] Meclofenoxate Hydrochloride 200g

[0036] Microcrystalline Cellulose 10g

[0037] 40g pregelatinized starch

[0038] Microporous silica gel 20g

[0039] Citric acid 5g

[0040] Specific preparation method:

[0041] Capsule filling: mix the above-mentioned meclofenoxate hydrochloride, microcrystalline cellulose, pregelatinized starch, microporous silica gel, and citric acid evenly, adopt the direct compression method, mix well, and fill the capsules to obtain hydrochloric acid in each capsule. Meclofenoxate 100mg.

Embodiment 2

[0043] The same method as in Example 1 is used to prepare a preparation containing 20 mg of active ingredient meclofenoxate hydrochloride, and the formulation of the pharmaceutical composition it uses is:

[0044] Meclofenoxate Hydrochloride 100g

[0045] Microcrystalline Cellulose 20g

[0046] 40g pregelatinized starch

[0047] Microporous silica gel 20g

[0048] Citric acid 5g

Embodiment 3

[0050] The same method as in Example 1 is used to prepare a preparation containing 20 mg of active ingredient meclofenoxate hydrochloride, and the formulation of the pharmaceutical composition it uses is:

[0051] Meclofenoxate Hydrochloride 100g

[0052] Microcrystalline Cellulose 5g

[0053] Pregelatinized starch 5g

[0054] Microporous silica gel 10g

[0055] Citric acid 5g

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to an alcaine methyl chloroformate compound which can avoid hydrolysis. Wherein, said compound comprises active component alcaine methyl chloroformate, findings, lubricant and stabilizer, while the stabilizer can keep the compound at weak acid. And the invention uses full powder compress method to avoid hydrolysis problem.

Description

technical field [0001] The present invention relates to a kind of meclofenoxate hydrochloride pharmaceutical composition that can prevent hydrolysis, more specifically, the present invention relates to a kind of meclofenoxate hydrochloride pharmaceutical composition that can prevent hydrolysis stabilizing agent. Background technique [0002] Meclofenoxate hydrochloride (Meclofenoxate, also known as meclofenoxate) can promote the metabolism of brain cells in the cerebral cortex, increase the effect on carbohydrates, and improve the excitability of nerve cells. In recent years, the scope of clinical application has gradually widened. , dullness, enuresis, all kinds of sluggishness and coma have significant curative effect. [0003] For example, Chinese patent application 03131072 discloses a preparation process and formula of a compound preparation containing meclofenoxate and Naofukang. This compound preparation has the effect of improving the disturbance of consciousness an...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K47/12A61K47/02A61K31/221A61P25/00A61P43/00
Inventor 张志生陈满英康秋萍李云霞
Owner GUANGDONG XIANQIANG PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap