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Pharmaceutical composition with Meclofenoxate hydrochloride capable of preventing hydrolysis

A technology of meclofenoxate hydrochloride and composition, which is applied in the field of meclofenoxate hydrochloride pharmaceutical composition that can prevent hydrolysis stabilizers, can solve the problems of easy hydrolysis or deliquescence of meclofenoxate hydrochloride, and achieve the effect of preventing hydrolysis

Active Publication Date: 2007-04-25
GUANGDONG XIANQIANG PHARMA +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, meclofenoxate hydrochloride is easily hydrolyzed or deliquescent

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Each preparation containing active ingredient meclofenoxate hydrochloride 100mg is prepared, and the prescription of the pharmaceutical composition it uses is:

[0035] Meclofenoxate Hydrochloride 200g

[0036] Microcrystalline Cellulose 10g

[0037] 40g pregelatinized starch

[0038] Microporous silica gel 20g

[0039] Citric acid 5g

[0040] Specific preparation method:

[0041] Capsule filling: mix the above-mentioned meclofenoxate hydrochloride, microcrystalline cellulose, pregelatinized starch, microporous silica gel, and citric acid evenly, adopt the direct compression method, mix well, and fill the capsules to obtain hydrochloric acid in each capsule. Meclofenoxate 100mg.

Embodiment 2

[0043] The same method as in Example 1 is used to prepare a preparation containing 20 mg of active ingredient meclofenoxate hydrochloride, and the formulation of the pharmaceutical composition it uses is:

[0044] Meclofenoxate Hydrochloride 100g

[0045] Microcrystalline Cellulose 20g

[0046] 40g pregelatinized starch

[0047] Microporous silica gel 20g

[0048] Citric acid 5g

Embodiment 3

[0050] The same method as in Example 1 is used to prepare a preparation containing 20 mg of active ingredient meclofenoxate hydrochloride, and the formulation of the pharmaceutical composition it uses is:

[0051] Meclofenoxate Hydrochloride 100g

[0052] Microcrystalline Cellulose 5g

[0053] Pregelatinized starch 5g

[0054] Microporous silica gel 10g

[0055] Citric acid 5g

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PUM

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Abstract

The invention relates to an alcaine methyl chloroformate compound which can avoid hydrolysis. Wherein, said compound comprises active component alcaine methyl chloroformate, findings, lubricant and stabilizer, while the stabilizer can keep the compound at weak acid. And the invention uses full powder compress method to avoid hydrolysis problem.

Description

technical field [0001] The present invention relates to a kind of meclofenoxate hydrochloride pharmaceutical composition that can prevent hydrolysis, more specifically, the present invention relates to a kind of meclofenoxate hydrochloride pharmaceutical composition that can prevent hydrolysis stabilizing agent. Background technique [0002] Meclofenoxate hydrochloride (Meclofenoxate, also known as meclofenoxate) can promote the metabolism of brain cells in the cerebral cortex, increase the effect on carbohydrates, and improve the excitability of nerve cells. In recent years, the scope of clinical application has gradually widened. , dullness, enuresis, all kinds of sluggishness and coma have significant curative effect. [0003] For example, Chinese patent application 03131072 discloses a preparation process and formula of a compound preparation containing meclofenoxate and Naofukang. This compound preparation has the effect of improving the disturbance of consciousness an...

Claims

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Application Information

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IPC IPC(8): A61K47/12A61K47/02A61K31/221A61P25/00A61P43/00
Inventor 张志生陈满英康秋萍李云霞
Owner GUANGDONG XIANQIANG PHARMA
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