Affinity particle and affinity separation method

A separation method and affinity technology, applied in the field of affinity particles and affinity separation, can solve the problems of difficult separation of affinity particles, low capture efficiency, carrier disintegration, etc., to prevent non-specific adsorption, high separation selectivity, improve The effect of purification efficiency
CN1956779AInactive Publication Date: 2007-05-02SHISEIDO CO LTD +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHISEIDO CO LTD
Publication Date
2007-05-02
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention is affinity particles that are characterized by having phosphorylcholine groups represented by the following formula (1) covalently bonded onto the surface of inorganic powder and also by having ligands having specific affinity with a certain target substance covalently bonded or adsorbed onto the surface of inorganic powder. The object of the present invention is to provide an affinity separation method that uses affinity particles utilizing inexpensive inorganic particles and is capable of separating the target substance easily and with high accuracy.
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Description

technical field

[0001] The present invention relates to affinity particles and affinity separation methods. More specifically, it relates to an affinity separation method using affinity particles using inorganic particles and capable of separating target substances with high precision and easily. It is also extremely useful for various separation, purification, and detection methods such as immunoprecipitation and latex agglutination, which can detect target substances with high precision and easily. Background technique

[0002] Conventionally, separation and purification of biological substances have been performed by column chromatography. However, there are fatal problems as shown in the following (1)-(3) in column separation.

[0003] (1) In order to obtain the target substance, various columns must be used, and the purification efficiency is poor.

[0004] (2) Confirmation experiments must be carried out to confirm whether the target substance is contained in the se...

Claims

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