Avian influenza virus marking vaccine, preparation process and application thereof

A kind of technology of avian influenza virus and avian influenza, applied in H5N1 subtype avian influenza virus labeled vaccine strain H5N1/PR8-5B19, the field of preparing said H5N1 subtype avian influenza virus labeled vaccine
CN1970081AInactive Publication Date: 2007-05-30HARBIN VETERINARY RES INST CHINESE ACADEMY OF AGRI SCI
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
HARBIN VETERINARY RES INST CHINESE ACADEMY OF AGRI SCI
Publication Date
2007-05-30
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a vaccine strain H5N1 / PR8-5B19 marked by H5N1 hypotype poultry influenza virus, which also provides the application to prevent and monitor poultry influenza.
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Description

technical field

[0001] The present invention relates to the field of recombinant virus vaccines, specifically, the present invention relates to a H5N1 subtype avian influenza virus labeled vaccine in which the dominant B cell epitope 5B19 of murine hepatitis virus S2 glycoprotein is inserted into the neck of the NA gene, more specifically , which is H5N1 subtype avian influenza virus marker vaccine strain H5N1 / PR8-5B19. The invention also discloses a method for preparing the H5N1 subtype avian influenza virus marker vaccine and the application of the marker vaccine in preparing vaccines for preventing avian influenza and in epidemiological monitoring of avian influenza. Background technique

[0002] 1. Reverse Genetic Technology of Type A Influenza Virus

[0003] In recent years, the molecular biology research of influenza virus has progressed rapidly, mainly in the fields of molecular epidemiology, influenza virus replication and regulation, influenza virus vector transfor...

Claims

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