Medicine composition for treating bird flu, its preparation method and use

A composition and avian influenza technology, which can be used in pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., can solve problems such as limited application, neurotoxicity, and drug resistance, and achieve broad economic value and important. Social value, strong effect

Active Publication Date: 2006-10-04
LIVZON PHARM GRP INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, these drugs have certain limitations:
[0009] (2) Ion channel blockers also have a good inhibitory effect on influenza A virus, but they are neurotoxic, and long-term medication is prone to drug resistance, causing influenza pandemics
Also, this drug is not effective against influenza B virus;
[0010] (3) Ribavirin (ribavirin) is effective against infections caused by RNA and DNA viruses, but these compounds have certain teratogenic effects, which limits their clinical application
However, the effect of these traditional Chinese medicine compositions for the treatment of bird flu is not significant, and cannot meet the needs of rapidly suppressing the outbreak of bird flu.

Method used

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  • Medicine composition for treating bird flu, its preparation method and use
  • Medicine composition for treating bird flu, its preparation method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] Embodiment 1: prepare the large volume injection of pharmaceutical composition of the present invention

[0072] Take 1000g of Radix Isatidis, 550g of Forsythia, 250g of Gypsum, 200g of Reed Root, 300g of Rehmannia, 300g of Patchouli, 280g of Iris, 180g of Curcuma, and 180g of Anemarrhena, and process it into herbal decoction pieces, add 8 times the amount of raw material in water, soak After 3 hours, decoct and extract twice, 1 hour each time, combine the extracts, filter, concentrate under reduced pressure to a relative density of 1.25 at 65°C, cool; add ethanol to make the alcohol content to 70%, and let it stand; take the above Clear liquid, recover and remove ethanol, concentrate to relative density of 1.15 at 65°C; use 2 times the amount of ethyl acetate for countercurrent extraction, combine ester extracts, recover and remove ethyl acetate, add full amount of 50% water for injection, boil , cool, filter, add an appropriate amount of water for injection, add 0.08%...

Embodiment 2

[0073] Embodiment 2: prepare the small volume injection of pharmaceutical composition of the present invention

[0074] Take 700g isatis root, 350g forsythia, 350g gypsum, 300g reed root, 300g rehmannia glutinosa, 50g patchouli, 30g turmeric, 30g anemarrhena, decoct with water, filter, concentrate the filtrate under reduced pressure, add ethanol and let it stand , filtered, concentrated under reduced pressure to 9g drug / ml, diluted with water, refrigerated, filtered, concentrated under reduced pressure, separated with a macroporous resin, rinsed with water, NaOH solution and 35wt% ethanol successively, and then the concentration was 75wt% ethanol solution, collect the eluate; add L-arginine to the eluent diluted with water, adjust the pH to 7.5, add activated carbon, heat and filter for decarbonization, add the same volume of water as the eluent to dilute, add The concentration of L-arginine is 4wt% of the total weight.

Embodiment 3

[0075] Embodiment 3 prepares the 20ml freeze-dried powder injection of pharmaceutical composition of the present invention

[0076] Take 300g of isatidis root, 100g of forsythia, 450g of gypsum, 80g of reed root, 150g of rehmannia glutinosa, 250g of patchouli, 300g of shichangpu, 250g of turmeric, and 600g of anemarrhena, add 3200ml of water for injection and soak for 1 hour, add 6400ml of water for injection and decoct for two minutes. times, each time for 1.5 hours, filter, and combine the filtrates to obtain the extract composition. Take 10g of the extraction composition, add an appropriate amount of water for injection to dissolve it, add 2.25g of sodium chloride, adjust the volume to 250ml with water for injection, add an appropriate amount of charcoal for injection, boil for 20 minutes, let cool, filter, sterilize, and divide by 1ml volume Fill it into a low boron glass ampoule, cool and dry to obtain a freeze-dried powder injection sample.

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Abstract

The invention discloses a pharmaceutical composition for treating and preventing bird flu, wherein the the active constituents include the following raw material herbs: radix isatidis 30.1 wt%, capsule of weeping forsythia 10.8 wt%, calcium sulphate 13.4 wt%, anemarrhena rhizome 5.8 wt%, reed rhizome 14.2 wt%, rehamnnia root 7.5 wt%, patchouli 6.6 wt%, acorus gramineus soland 5.8 wt%, curcuma root 5.8 wt%. The composition can be prepared into any of the conventional dosage forms, such as oral liquids, tablets, capsules, granules and injections. The invention also provides the process for preparing the pharmaceutical composition.

Description

technical field [0001] The present invention relates to a pharmaceutical composition with the effect of preventing and treating avian influenza, its preparation method and application, in particular to a pharmaceutical composition with the effect of preventing and treating avian influenza made from traditional Chinese medicines, and its preparation Methods and uses. Background technique [0002] Avian influenza (AI) is a severe infectious disease syndrome in poultry birds caused by type A influenza virus. The infected animals are geese, chickens, ducks, pigeons and some wild birds. Epidemiological studies have shown that avian influenza virus (AIV) is highly pathogenic and highly transmissible, and is classified as a Class A infectious disease by the International Office of Epizootics, also known as fowlplague or European fowl plague. According to the type of pathogen, avian influenza can be divided into three categories: highly pathogenic, low pathogenic and non-pathogenic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8964A61K36/899A61K36/9066A61K9/16A61P31/16
Inventor 陶德胜曾永清曹晖管秩
Owner LIVZON PHARM GRP INC
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