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Oral devices and methods for controlled drug delivery

A technology for delivering devices and medicines, which can be used in medicine delivery, medicine devices, medicine formulations, etc., and can solve problems such as lack of controlled delivery rates.

Inactive Publication Date: 2007-07-11
安迪·沃尔夫 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These devices deliver drugs into the oral cavity, but they lack a controlled rate of delivery for extended periods of time, which is extremely important for the prevention and treatment of the above-mentioned diseases and conditions

Method used

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  • Oral devices and methods for controlled drug delivery
  • Oral devices and methods for controlled drug delivery
  • Oral devices and methods for controlled drug delivery

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0397] Example 1: Passive Controlled Delivery of Drugs

[0398] Device 140 designed as a prosthetic crown 160 ( FIGS. 8A-8B ) for passive drug-controlled delivery, or another device for passive drug-controlled delivery, may include a drug reservoir 156 that is coated with osmotic A semipermeable membrane cyclosporine dosage form for sexually controlled drug delivery. Semipermeability is formed by hydrophobic polymers mixed with water soluble additives, such as cellulose acetate, or ethyl cellulose, such as sugar, PEG, etc. Upon administration, the soluble additive dissolves and creates a semipermeable membrane. Cyclosporine is delivered continuously at a rate of 0.5-2 mg per day. Tablets can be replaced about once a month. In comparison, when absorbed, gastric retention in the upper gastrointestinal tract typically does not exceed about 12 hours.

[0399] Levodopa can be used in place of cyclosporine in a similar manner. Alternatively, somatotropin in combination with a s...

Embodiment 2

[0400] Example 2: Delayed Passive Controlled Delivery of Drugs

[0401] A device 140 designed as a prosthetic crown 160 ( FIGS. 8A-8B ) for passive drug controlled delivery or another device for passive drug controlled delivery may include several drug reservoirs 156 where a first reservoir includes Dosage forms suitable for passively controlled delivery, e.g. by diffusion and erosion; the second drug reservoir comprises a dosage form coated with a specific functional coating designed to delay the delivery of the second reservoir until the dosage form of the first reservoir is depleted do. In this way, the replacement interval can be extended.

Embodiment 3

[0402] Example 3: Pulsed Passive Drug Controlled Delivery

[0403] A device 140 designed as a prosthetic crown 160 ( FIGS. 8A-8B ) for passive drug controlled delivery or another device for passive drug controlled delivery may include a drug reservoir 156 comprising a dosage form having a multilayer coating , and designed for passively controlled delivery in pulses that can be synchronized with, for example, the circadian rhythm cycle for desired long-term therapy.

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PUM

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Abstract

Controlled-drug-delivery oral devices are implanted or inserted into an oral cavity, built onto a prosthetic tooth crown, a denture plate, braces, a dental implant, or the like. The devices are refilled or replaced as needed. The controlled drug delivery may be passive, based on a dosage form, or electro-mechanically controlled, for a high-precision, intelligent, drug delivery. Additionally, the controlled delivery may be any one of the following: delivery in accordance with a preprogrammed regimen, delivery at a controlled rate, delayed delivery, pulsatile delivery, chronotherapeutic delivery, closed-loop delivery, responsive to a sensor's input, delivery on demand from a personal extracorporeal system, delivery regimen specified by a personal extracorporeal system, delivery on demand from a monitoring center, via a personal extracorporeal system, and delivery regimen specified by a monitoring center, via a personal extracorporeal system. Drug absorption in the oral cavity may be assisted or induced by a transport mechanism, such as any one of, or a combination of iontophoresis, electroosmosis, electrophoresis, electroporation, sonophoresis, and ablation. The oral devices require refilling or replacement at relatively long intervals of weeks or months, maintain a desired dosage level in the oral cavity, hence in the gastrointestinal tract, for extended periods, address situations of narrow drug therapeutic indices, and by being automatic, ensure adherence to a prescribed medication regimen. The oral devices and methods for controlled drug delivery apply to humans and animals.

Description

technical field [0001] The present invention relates to controlled drug delivery and monitoring, and more particularly, to oral devices and methods that provide multiple drug delivery protocols and clinical sampling methods. Background technique [0002] Oral administration is the most common route of drug delivery, and more than half of the drugs on the market are administered for this route. Drug delivery from the gastrointestinal tract at a controlled rate is desired to maintain controlled levels of the drug in the bloodstream and tissues through the patient, and to control diurnal variations resulting from oral intake at specific times of the day. However, the bioavailability of oral administration, the extent to which the drug reaches the target tissue, is affected by drug dissolution, drug degradation, and drug absorption in the gastrointestinal tract, and is generally not constant over time. Certain drugs have high bioavailability, which may dissolve and absorb so qu...

Claims

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Application Information

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IPC IPC(8): A61M31/00A61K9/22
Inventor 安迪·沃尔夫本·Z·贝伊斯基约拉姆·塞拉
Owner 安迪·沃尔夫
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