Device for delivery of multiple liquid sample streams to a mass spectrometer

Inactive Publication Date: 2002-04-18
MDS PROTEOMICS INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When multiple sample streams are prepared, it is time consuming to switch between successive sample streams.
Aside from the time involved in switching streams, the possibility exists for cross-contamination of the various streams.

Method used

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  • Device for delivery of multiple liquid sample streams to a mass spectrometer
  • Device for delivery of multiple liquid sample streams to a mass spectrometer
  • Device for delivery of multiple liquid sample streams to a mass spectrometer

Examples

Experimental program
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Effect test

Embodiment Construction

[0045] A four needle multisprayer apparatus was constructed according to the embodiment of FIG. 3, with a radial arrangement of needles on a rotatable plate or hub. The assembly was positioned vertically in front of the sampling plate as described herein. Four needles were positioned 90 degrees apart. As a demonstration of the device, a single needle was selected and connected to a flowing stream consisting of a 10 .mu.M solution of a derivatized trisaccharide (with a m / z value of 681.2 u) in 1:1 acetonitrile:buffer (2 mM ammonium acetate, pH 7.2). No other streams were analyzed. A Hewlett-Packard series 1100 MSD electrospray mass spectrometer (quadrupole) was used, in selected ion monitoring mode. The needle connected to the flowing stream (10 .mu.L / min) was positioned in front of the sampling orifice for maximum ion transmission, and mass spectrometer conditions were optimized for the monitoring of this compound. The needle assembly was then rotated 90 degrees at a fixed rate of 5...

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PUM

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Abstract

An electrospray apparatus employing multiple electrospray needles mounted in a circular arrangement sequentially delivers multiple sample streams to a mass spectrometer for analysis. One electrospray device includes an electrospray chamber, a rotatable needle supporting plate, a plurality of electrospray needles mounted on the plate, and a charger for applying a charge to droplets delivered to the electrospray chamber by the needles. Another electrospray device includes an electrospray chamber, a plurality of electrospray needles arranged in a circular arrangement, a charger, and a rotatable member for delivering gas phase ions from one needle at a time to the mass spectrometer. The rotatable electrospray apparatus provides fast repetitive analysis of simultaneously operating chromatography columns or other sample streams with a single mass spectrometer.

Description

[0001] This application is a continuation-in-part of U.S. Ser. No. 09 / 069,656, filed Apr. 29, 1998, which application claims the benefit of U.S. Provisional Application No. 60 / 079,622, filed Mar. 27, 1998. Each of these applications are incorporated herein-by reference in their entirety.[0002] 1. Field of the Invention[0003] The invention relates to liquid delivery devices, and more particularly, the invention relates to devices for delivery of multiple liquid sample streams to a mass spectrometer for analysis of compound libraries.[0004] 2. Brief Description of the Related Art[0005] In recent years, a large number of combinatorial chemistry techniques have been developed which permit vast libraries of diverse chemical compounds to be rapidly synthesized. In combinatory chemistry, a series of chemical reactions is conducted, typically employing a plurality of reagents at each step, to generate a library of compounds. Such techniques have the potential to greatly accelerate the disco...

Claims

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Application Information

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IPC IPC(8): B01D59/44C40B30/08G01N27/62C40B40/12C40B40/18G01N30/46G01N30/62G01N30/72G01N30/84G01N33/538G01N33/543G01N33/68G01N37/00H01J49/04H01J49/10
CPCB01J2219/00585Y10T436/2575B01J2219/00707B01J2219/00731B01J2219/00738B01J2219/00745B01J2219/00747C40B30/08C40B40/12C40B40/18G01N30/466G01N30/7266G01N33/538G01N33/54306G01N33/54366G01N33/68G01N2030/628G01N2030/8429G01N2030/847H01J49/165Y10T436/24Y10T436/25Y10T436/25375B01J2219/00704
Inventor HINDSGAUL, OLESCHRIEMER, DAVID C.
Owner MDS PROTEOMICS INC
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