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Modulators of the function of FAS/APO1 receptors

a technology of fas/apo1 and receptors, which is applied in the field of modulators of the function of fas/apo1 receptors, can solve the problems of little understanding of the mechanism of triggering

Inactive Publication Date: 2002-06-27
YEDA RES & DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

MORT-1 effectively modulates the FAS-R ligand effect on cells, allowing for the inhibition or enhancement of cytotoxicity, providing therapeutic potential in conditions like cancer and HIV infection by regulating the intracellular signaling of FAS-R.

Problems solved by technology

tious agent. However, both TNF-.alpha. and TNF-.beta. also have delet
Further, it should also be mentioned that, while it is known that the tumor necrosis factor (TNF) receptors, and the structurally-related receptor FAS-R, trigger in cells, upon stimulation by leukocyte-produced ligands, destructive activities that lead to their own demise, the mechanisms of this triggering are still little understood.

Method used

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  • Modulators of the function of FAS/APO1 receptors
  • Modulators of the function of FAS/APO1 receptors
  • Modulators of the function of FAS/APO1 receptors

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

: Cloning and isolation of the MORT-1 protein which binds to the intracellular domain of the FAS-R

(i Two-hybrid screen and two-hybrid .beta.-galactosidase expression test

[0113] To isolate proteins interacting with the intracellular domain of the FAS-R, the yeast two-hybrid system was used (Fields and Song, 1989; see also co-pending IL 109632, 112002 and 112692). Briefly, this two-hybrid system is a yeast-based genetic assay to detect specific protein-protein interactions in vivo by restoration of a eukaryotic transcriptional activator such as GAL4 that has two separate domains, a DNA binding and an activation domain, which domains when expressed and bound together to form a restored GAL4 protein, is capable of binding to an upstream activating sequence which in turn activates a promoter that controls the expression of a reporter gene, such as lacZ or HIS3, the expression of which is readily observed in the cultured cells. In this system the genes for the candidate interacting protei...

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Abstract

The MORT-1 protein, analogs thereof and fragments thereof bind with the intracellular domain of the FAS ligand receptor. DNA encoding such protein, analogs and fragments, may be used to make vectors and host cells in order to produce such proteins, analogs and fragments. The peptides may be formulated into pharmaceutical compositions for use in modulation of the FAS-R ligand effect on cells carrying a FAS-R.

Description

FIELD OF THE INVENTIONS[0001] The present invention is generally in the field of receptors belonging to the TNF / NGF superfamily of receptors and the control of their biological functions. The TNF / NGF superfamily of receptors includes receptors such as the p55 and p75 tumor necrosis factor receptors (TNF-Rs) and the FAS ligand receptor (also called FAS / APO1 or FAS-R and hereinafter will be called FAS-R) and others. More specifically, the present invention concerns a novel protein, herein designated MORT-1 (also called HF-1) which binds to the intracellular domain (IC) of the Fas-R, (this intracellular domain designated Fas-IC) and which novel protein is capable of modulating the function of the Fas-R. Further, MORT-1 is also capable of self-association and can activate cell cytotoxicity on its own. The present invention also concerns the preparation and uses of MORT-1.[0002] It should be noted that HF-1 (the original designation) and MORT-1 (the presently used designation) are both u...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K38/00C07K14/705C07K14/715C07K16/28C12N9/64
CPCA61K38/00C07K14/70578C07K14/715C12N9/6475C07K2319/00C12N9/641C07K16/2866
Inventor WALLACH, DAVIDBOLDIN, MARKVARFOLOMEEV, EUGENEMETT, IGOR
Owner YEDA RES & DEV CO LTD
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