Process and device for preparing radiopharmaceutical products for injection

a radiopharmaceutical and process technology, applied in the direction of packaging/bundling articles, containers, packaging goods, etc., can solve the problems of increasing the level of automation, requiring a large amount of automation, and causing an appreciable cumulative exposur

a radiopharmaceutical and process technology, applied in the direction of packaging/bundling articles, containers, packaging goods, etc., can solve the problems of increasing the level of automation, requiring a large amount of automation, and causing an appreciable cumulative exposur

US20040084340A1Inactive Publication Date: 2004-05-06MORELLE JEAN LUC
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  • Process and device for preparing radiopharmaceutical products for injection
  • Process and device for preparing radiopharmaceutical products for injection
  • Process and device for preparing radiopharmaceutical products for injection

Examples

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Embodiment Construction

[0055] The present invention is related to a method and devices for preparing, packaging and handling individual doses of an injectable radiopharmaceutical compound. The method combines and incorporates the functions of filling (production) and transportation (packaging) and use while at the same time allowing the production to be easily automated.

[0056] The method of the invention comprises the following steps:

[0057] filling a "cartridge" 1 with an injectable substance of a radiopharmaceutical compound (FIG. 1);

[0058] closing said cartridge 1 at one end by means of a setting elastomeric (rubber) stopper 2 to be capable of being pierced, such as a septum. The cartridge comprises a rubber piston 3 at the other end. The filling and closing may be performed automatically using a suitable dispensing device. A cartridge as is known to contain insulin may be used for this purpose;

[0059] placing the cartridge in a radiation shielding device 10 consisting of two concentric parts (FIG. 2): a...

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Abstract

Method for preparing, packaging and handling an individual dose of a radiopharmaceutical compound, comprising the following steps: filling a cartridge (1) with said dose of radiopharmaceutical compound via a first end, the second end being closed by means of a component serving as a piston (3); closing said cartridge (1) at said first end by means of a closure device (2); placing said cartridge (1) in a radiation shielding device (10), comprising an inner part (4) and an outer part (5), said inner part serving as radiation shielding for an operator and said outer part serving as a transportation shielding container; closing said container by means of an appropriate shielding lid (6); transporting said container up to the place at which an injection of said radiopharmaceutical compound will take place; removing the shielding lid (6) of the container; fixing a plunger (7) to the cartridge piston (3); extracting the cartridge and the inner part (4) of the radiation shielding device (10) from the outer part (5) serving as a container, and placing injection means (30) on the cartridge end which has the setting closure device (2).

Description

[0001] The present invention is related to practices in nuclear medicine, and in particular to a process for preparing radiopharmaceutical products for injection.STATE OF THE ART[0002] The development of nuclear medicine, in particular in the field of diagnosis by positron emission tomography (PET), makes it necessary to review the usual methods for producing, packaging and handling radiopharmaceutical substances intended for administration to patients.[0003] Radiopharmaceutical substances are chemical compounds labeled with radioactive isotopes, intended for medical use. Problems of existing methods and equipment are mainly due to the increase in the use of isotopes whose radiation energy is relatively high, and by the fact that a higher level of automation is required due to the short half-life of said isotopes.[0004] Dose fractionation systems are available on the market. They make it possible to dilute a base radiopharmaceutical product, to prepare the dilute solution in vials a...

Claims

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Application Information

Patent Timeline
06 May 2004
Publication
US20040084340A1
IPC
A61J1/00; G21F5/018; A61J1/14; A61J1/06; A61M5/24; A61M5/178; G21G4/08
CPC
A61M5/1785; G21F5/018; A61M5/24
Inventors
MORELLE, JEAN-LUC; PHILIPPART, GAUTHIER